Humoral Mechanisms Regulating the Functions of Progenitor Cells in Chronic Hepatitis

We studied the effect of hyaluronate-endo-β-N-acetylhexosaminidase on the secretory function of the liver and bone marrow microenvironment cells in chronic hepatitis. Enhanced production of substances stimulating parenchymal tissue-specific precursors and stem cell homing factors by liver cells was revealed. At the same time, production of SDF-1 and other chemoattractants and adhesion factors of progenitor cells by bone marrow elements was reduced.

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Effect of Pegylated Hyaluronate-Endo-β-N-Acetylhexosaminidase on Humoral Mechanisms Regulating the Functions of Progenitor Cells during Chronic Hepatitis

Дыгай

Zyuz’kov

Гурто

et al. 2013

Bull Exp Biol Med

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Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions

et al. 2015

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PI3- and MAP-kinase signaling pathways duplicate and interchange each other in production of agents that determine total erythropoietic activity under conditions of balanced erythropoiesis. The alternative p38-dependent MAP-kinase pathway is the major regulator of erythropoietic activity of adherent bone marrow cells. Blockade of PI3K and p38 signaling pathways stimulated production of erythropoietin by cells that do not produce it constitutively.

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Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss

et al. 2016

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The leading role in the regulation of erythropoietic activity of adherent bone marrow cells under conditions of post-hemorrhagic anemia is played by classical MAP kinase pathway (ERK pathway). Erythropoietin is not the decisive factor in the formation of erythropoietic activity of adherent cells. PI3K, MAPK/ERK 1/2, and p38-signaling proteins are not the main regulators of local production of erythropoietin after 30% loss of circulating blood volume.

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Humoral Mechanisms Regulating the Functions of Progenitor Cells in Chronic Hepatitis

Cited by 3 publications

References 7 publications

Effect of Pegylated Hyaluronate-Endo-β-N-Acetylhexosaminidase on Humoral Mechanisms Regulating the Functions of Progenitor Cells during Chronic Hepatitis

Effect of Pegylated Hyaluronate-Endo-β-N-Acetylhexosaminidase on Humoral Mechanisms Regulating the Functions of Progenitor Cells during Chronic Hepatitis

Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions

Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss

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