Humoral response in patients with chronic heart failure

Špinarová, Lenka; Toman, Jiřı́; Pospísilová, J; Souček, Miroslav; Kára, Tomáš; Stejfa, M

doi:10.1016/s0167-5273(98)00116-8

Cited by 9 publications

(6 citation statements)

References 18 publications

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“…In addition, activation of the neuroendocrine system in patients with chronic heart failure leads to increased levels of norepinephrine, angiotensin II, arginine vasopressin, endothelin, thromboxane A2 and prostaglandin F in the blood vessels, vasoconstriction leads to renal ischemia, resulting in decreased erythropoietin synthesis, therefore reduced erythropoiesis eventually cause anemia. 21 And renal insufficiency eventually leads to Anemia caused by a decrease in EPO, and also we found that in RDW in patients with CHF is more closely associated with Glomerular filtration rate. 22…”

Section: Anemia-related Mechanismssupporting

confidence: 62%

Study of the correlation between red blood cell parameters in the patients with coronary heart disease and heart failure

et al. 2017

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Background: An increase of red blood cell distribution width (RDW) may have a certain effect to predict and evaluate the incidence and prognosis of coronary heart disease or chronic heart failure.Methods: Our retrospective study covered a total of 230 patients that were included due to a variety of indications for coronary angiography. Patients were defined into 2 categories; CAG (-) group (n=100), and CAG (+) group (n=130). The 2 groups were compared in order to investigate the differences between their RDW and other factors related and then further were sub-dived into 4 groups according to the NYHA functional class.Results: We observed that the patients in CAG (-) group 12.78±0.90; CAG (+) group 12.90±1.10 and had no significant difference in RDW. However higher RDW in patients with HF on all-cause was detected, 13.50±1.12 of group CAG (-)/NYHA II-IV and 13.39±1.31 of group CAG (+)/NYHA II-IV and there is statistical difference compared to group CAG (-)/NYHAI and group CAG (+)/NYHA I which were 12.80±0.47 and 12.87±0.69 respectively (P<0.001). There has no difference between the HF groups CAG (-)/NYHA II-IV and CAG (+)/NYHA II-IV group with (P=0.920), and no difference between groups without heart failure of (P=0.979).Conclusions: Although RDW had no predictive ability of coronary heart disease, but the elevation of RDW was highly and independently associated with chronic HF. Therefore, RDW can be clinically used as a parameter in risk stratification of patients with HF.

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Section: Anemia-related Mechanismssupporting

confidence: 62%

Study of the correlation between red blood cell parameters in the patients with coronary heart disease and heart failure

et al. 2017

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“…In CHF patients, big ET1 is used primarily as a prognostic marker [15,[22][23][24][25]. Natriuretic peptides have been widely used in the evaluation of diagnosis and prognosis in patients with CHF; hence, they are also of value in long term CHF management.…”

Section: Current Clinical Applications Of Big Et1 and Bnp In Patientsmentioning

confidence: 99%

The value of B‐type natriuretic peptide and big endothelin‐1 for detection of severe pulmonary hypertension in heart transplant candidates

Kubánek

Málek

Kautzner

et al. 2005

European J of Heart Fail

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Background: Severe pulmonary hypertension (PH) and increased pulmonary vascular resistance (PVR) are important risk factors that predict early postoperative mortality after orthotopic heart transplantation. The aim of our study was to determine the value of B-type natriuretic peptide (BNP) and big endothelin-1 (big ET1) for prediction of severe PH in heart transplant candidates. Methods: The study population included 43 potential heart transplant candidates (38 males, mean age 52F7 years). All underwent repeated right-heart catheterizations (2-5 studies) at an interval of 3-4 months, giving a total of 124 examinations, associated with blood sampling for BNP and big ET1 analysis. Severe PH was defined as the mean pulmonary artery pressure (MPAP)N40 mmHg. Results: Significantly high PVR (PVRN3.0 Wood units and TPGN15 mmHg) was noted on 12 occasions in 10 patients; always in the presence of severe PH. Low BNP levels (b67 pg/ml) ruled out the presence of severe PH with a 100% sensitivity, however, with a low specificity (34%). An increase in plasma BNPN30 pg/ml (N40% of initial value) in subjects with a previous MPAPV40 mmHg detected development of severe PH with a 100% sensitivity and an 80-88% specificity. As a total of 58% of patients presented repeatedly with MPAPV40mmHg, serial BNP testing could reduce the need for hemodynamic studies in this subgroup down to 12-20%. Conclusions: Serial BNP testing in hemodynamically stable heart transplant candidates with MPAPV40 mmHg allows reliable detection of development of severe PH, and may significantly reduce the need for repeated right-heart catheterizations in these patients.

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“…Increased RDW may comprehensively reflect the following pathophysiological mechanisms in occurrence and development of sepsis: a) inflammation may cause an increase of neuro-hormone and endocrine hormone in the body including noradrenaline, angiotensin1 and other angiotensins level and renal ischemia. These neurotransmitters can stimulate red blood cell proliferation through promoting the generation of erythropoietin (EPO) to result in RDW increase [12]. b) Inflammatory factors may affect marrow hemopoietic function and iron metabolism in the body to cause RDW increase [13,14].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Red Cell Distribution Width (RDW), Mean Platelet Volume (MPV), and Platelets Count in Sudanese Neonates with Proven Sepsis

Ahmed¹,

Mohammed²,

Babiker³

et al. 2020

SJBR

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Background: Sepsis is a life-threatening clinical condition that has cost humanity heavily since time immemorial. The aim of the study was to investigate the relationship between the red blood cell distribution width (RDW), mean platelet volume (MPV) platelet count, and neonatal sepsis in Sudan. Material and Method: A prospective cross sectional hospitalized based study was conducted in Omdurman maternity hospital, in the period from June 2013 to April 2015.Hundred Sudanese neonates were grouped equally into two; case group were neonates with proven sepsis by the culture (N=50), and control group were healthy neonates (N=50). Mean Platelet Volume (MPV), red blood cell distribution width (RDW), and platelet count were performed by using hematological analyzer (KX-21 Sysmex) and the results compared between two groups. Result: Of the fifty sepsis group 23 (46%) were male, and 27(54%) were female. Whereas in control group 24 (48%) were male, and 26 (52%) were female. The mean age in case group was 9 days, and in control group was 4.3 days. The mean of platelet count was significantly lower in sepsis group than control, P value (<0.001). The mean of MPV and RDW CV were significantly higher in sepsis group than control, P. value (<0.001, and 0.026 respectively). In sepsis group, there were no significant change in MPV, RDW CV, and platelet count according to fate between died and recovered patient. Conclusions: The MPV and RDW were higher where as platelets count was lower in neonatal sepsis and these tests were inexpensive and commonly measured and may be with value in diagnosis and prognosis for neonatal sepsis. Further studies are required to determine the predicting value for MPV, RDW CV, and platelet count in neonatal sepsis.

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Humoral response in patients with chronic heart failure

Cited by 9 publications

References 18 publications

Study of the correlation between red blood cell parameters in the patients with coronary heart disease and heart failure

Study of the correlation between red blood cell parameters in the patients with coronary heart disease and heart failure

The value of B‐type natriuretic peptide and big endothelin‐1 for detection of severe pulmonary hypertension in heart transplant candidates

Diagnostic Value of Red Cell Distribution Width (RDW), Mean Platelet Volume (MPV), and Platelets Count in Sudanese Neonates with Proven Sepsis

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