Humoral response to Mycobacterium avium subsp. avium in naturally infected ring-neck doves (Streptopelia risoria)

Gray, Patricia L.; Saggese, Miguel D.; Phalen, David N.; Tizard, Ian R.

doi:10.1016/j.vetimm.2008.05.032

Cited by 9 publications

(2 citation statements)

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“…The disease, etiology, differential susceptibility to disease, and efficacy of different diagnostic methods was investigated in 29 of these birds and was reported previously. [28][29][30] Of the surviving group of 70 ring-neck doves, 16 were randomly selected to be included in an uncontrolled clinical study. Treatment was begun in these 16 doves immediately after being received at the Schubot Exotic Bird Health Center.…”

Section: Specimensmentioning

confidence: 99%

“…28 Additionally, Western blot analysis of plasma samples and hematologic testing and plasma protein electrophoresis results were used as criteria for preliminary antemortem classification as infected. [29][30][31] This included a combination of 3 or more of the following clinicopathologic results consistent with mycobacteriosis in doves [28][29][30][31] : positive results of Western blot analysis, anemia, leukocytosis, heterophilia, monocytosis, hyperglobulinemia, and hypoalbuminemia. All 16 doves in the trial met the established criteria for antemortem diagnosis of mycobacterial infection.…”

Section: Specimensmentioning

confidence: 99%

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Evaluation of Multidrug Therapy With Azithromycin, Rifampin, and Ethambutol for the Treatment ofMycobacterium aviumsubspaviumin Ring-neck Doves (Streptopelia risoria): An Uncontrolled Clinical Study

Saggese¹,

Tizard²,

Gray³

et al. 2014

Journal of Avian Medicine and Surgery

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An uncontrolled clinical study was conducted to evaluate the efficacy of a multidrug protocol in 16 ring-neck doves ( Streptopelia risoria ) from a flock naturally infected with Mycobacterium avium subsp avium. The doves were considered infected on the basis of a high prevalence of infection in a group of 29 birds that were euthanatized from the same flock and clinical signs and pathologic results consistent with infection in the remaining birds. All birds were treated with azithromycin (43 mg/kg), rifampin (45 mg/kg), and ethambutol (30 mg/kg) administered orally once daily for 180 days. Five birds died during treatment and were confirmed positive for mycobacteriosis on postmortem examination. Of the remaining 11 birds, infection and disease were present in 9 (81.8%) at the end of the treatment. Postmortem investigation showed that 2 mycobacterial isolates were resistant to ethambutol, intermediately sensitive to rifampin, and sensitive to azithromycin. Microscopic examination of liver sections equivalent of those that would be taken for biopsy showed that biopsy as a method of monitoring birds for treatment success had poor sensitivity. Toxicity associated with drug therapy was not observed in these doves nor in 6 outwardly healthy ring-neck doves exposed to the same treatment. The results of this study showed that this protocol of azithromycin, rifampin, and ethambutol has poor efficacy when administered for 180 days for treatment of doves infected with M avium subsp avium.

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Section: Specimensmentioning

confidence: 99%