2022
DOI: 10.1111/bjh.18447
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Humoral response to mRNA‐based COVID‐19 vaccine in patients with de novo and pre‐existing immune thrombocytopenia with exacerbation of thrombocytopenia after vaccination

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Cited by 4 publications
(5 citation statements)
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“…Furthermore, since ITP develops after COVID-19 vaccination in both healthy individuals and preexisting ITP patients, the vaccine response in ITP patients is a great concern for both patients and their physicians. 8,12 Here we revealed that the seroconversion rate after vaccination in ITP patients was comparable to that in HCs; however, the median antibody titre was significantly lower in ITP patients than in HCs. In contrast, it has been reported that patients with autoimmune inflammatory rheumatic disease (AIIRD) have significantly lower seroconversion rates as well as antibody titres than healthy individuals.…”
Section: Discussionmentioning
confidence: 57%
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“…Furthermore, since ITP develops after COVID-19 vaccination in both healthy individuals and preexisting ITP patients, the vaccine response in ITP patients is a great concern for both patients and their physicians. 8,12 Here we revealed that the seroconversion rate after vaccination in ITP patients was comparable to that in HCs; however, the median antibody titre was significantly lower in ITP patients than in HCs. In contrast, it has been reported that patients with autoimmune inflammatory rheumatic disease (AIIRD) have significantly lower seroconversion rates as well as antibody titres than healthy individuals.…”
Section: Discussionmentioning
confidence: 57%
“…However, data for COVID‐19 vaccine responses in patients with ITP are very limited. Furthermore, since ITP develops after COVID‐19 vaccination in both healthy individuals and pre‐existing ITP patients, the vaccine response in ITP patients is a great concern for both patients and their physicians 8,12 …”
Section: Discussionmentioning
confidence: 99%
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“…Although it is difficult to determine whether the development of a disease after vaccination was vaccine induced or accidental, various cases of autoimmune disease have been reported after COVID-19 vaccination including autoimmune hepatitis, type 1 diabetes mellitus, acquired hemophilia, ITP, and autoimmune hemolytic anemia as well as aggravation of pre-existing hematologic diseases such as PNH [ 7 , 25 35 ]. Although the pathogenetic mechanisms by which vaccines cause the development of autoimmune diseases are not yet understood, almost all of the hematologic manifestations after COVID-19 vaccination in previous studies were thought to be related to autoimmune pathways [ 11 ].…”
Section: Discussionmentioning
confidence: 99%