Huntington Disease and Other Genetic Choreas

Altered Fractional Anisotropy in Early Huntington's Disease

“…More specifically, the disease is linked to expansion of the CAG repeat tract of this gene, which codes for polyglutamine repeats in the huntingtin protein [1]. …”

“…George Huntington discussed ‘tendency to insanity and suicide’ in his original paper [1]. Psychiatric manifestations may include irritability, anxiety, obsessive compulsive disorder, paranoid ideation, and psychosis.…”

“…Psychiatric manifestations may include irritability, anxiety, obsessive compulsive disorder, paranoid ideation, and psychosis. Depression is the most common psychiatric feature of HD and suicidal ideation occurs in 5–10% of HD patients [1]. Other neurologic manifestations include eye movement abnormalities, cognitive disturbance, pendular knee reflexes, motor impersistence [1], and postural instability [4].…”

“…Depression is the most common psychiatric feature of HD and suicidal ideation occurs in 5–10% of HD patients [1]. Other neurologic manifestations include eye movement abnormalities, cognitive disturbance, pendular knee reflexes, motor impersistence [1], and postural instability [4]. Juvenile onset HD presents primarily with dystonia and rigidity [1].…”