Huntington's Disease and Its Association with Psychopathology

Marchi, Nicola; Mennella, R.

doi:10.3109/hrp.7.5.278

Cited by 31 publications

(8 citation statements)

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“…In particular, excessive relative activity in the direct pathway in OFC/ACC CBGTC loops has been suggested to result in a positive feedback loop in which obsessive thoughts become “trapped” (Baxter et al, 2001; Saxena et al, 1998, 2001; Saxena & Rauch, 2000). Consistent with this idea, the prevalence of obsessive–compulsive symptoms is significantly greater in Huntington disease than in the general population (Anderson, Louis, Stern, & Marder, 2001; Beglinger et al, 2007; De Marchi & Mennella, 2000), and some case reports describe onset of OCD following the onset of Huntington disease (Cummings & Cunningham, 1992; Scicutella, 2000).…”

Section: Cortico–basal Ganglia–thalamo–cortical (Cbgtc) Loops and Thementioning

confidence: 90%

The neural bases of obsessive–compulsive disorder in children and adults

2008

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Functional imaging studies have reported with remarkable consistency hyperactivity in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and caudate nucleus of patients with Obsessive-Compulsive Disorder (OCD). These findings have often been interpreted as evidence that abnormalities in cortico-basal ganglia-thalamo-cortical loops involving the OFC and ACC are causally related to OCD. This interpretation remains controversial, however, because such hyperactivity may represent either a cause or a consequence of the symptoms. This article analyzes the evidence for a causal role of these loops in producing OCD in children and adults. The article first reviews the strong evidence for anatomical abnormalities in these loops in patients with OCD. These findings are not sufficient to establish causality, however, because anatomical alterations may themselves be a consequence rather than a cause of the symptoms. The article then reviews three lines of evidence that, despite their own limitations, permit stronger causal inferences: the development of OCD following brain injury, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection, and neurosurgical lesions that attenuate OCD. Converging evidence from these various lines of research supports a causal role for the cortico-basal ganglia-thalamo-cortical loops that involve the OFC and ACC in the pathogenesis of OCD in children and adults.

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Section: Cortico–basal Ganglia–thalamo–cortical (Cbgtc) Loops and Thementioning

confidence: 90%

The neural bases of obsessive–compulsive disorder in children and adults

2008

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“…The presence of obsessive and compulsive symptoms (OCs) has been previously documented in patients with HD as less common than other psychiatric symptoms [65,69,70,71,72]. However, a study by Marder et al reported that 22.3% had obsessive and compulsive symptoms at their first clinical visit, suggesting that these symptoms may be more common than previously recognized in this population.…”

Section: Clinical Features In Hd and Psychiatric Disordersmentioning

confidence: 93%

“…Hypersexual behavior is more prevalent in men, ranging from 3.9%–30% vs. 2.1%–25% in women [72,87,88]. In a pioneer study, Dewhurst et al [72] reported in their article some social consequences of these symptoms.…”

Section: Clinical Features In Hd and Psychiatric Disordersmentioning

confidence: 99%

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Neuropsychiatric Burden in Huntington’s Disease

et al. 2017

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Huntington’s disease is a disorder that results in motor, cognitive, and psychiatric problems. The symptoms often take different forms and the presence of disturbances of the psychic sphere reduces patients’ autonomy and quality of life, also impacting patients’ social life. It is estimated that a prevalence between 33% and 76% of the main psychiatric syndromes may arise in different phases of the disease, often in atypical form, even 20 years before the onset of chorea and dementia. We present a narrative review of the literature describing the main psychopathological patterns that may be found in Huntington’s disease, searching for a related article in the main database sources (Medline, ISI Web of Knowledge, Scopus, and Medscape). Psychiatric conditions were classified into two main categories: affective and nonaffective disorders/symptoms; and anxiety and neuropsychiatric features such as apathy and irritability. Though the literature is extensive, it is not always convergent, probably due to the high heterogeneity of methods used. We summarize main papers for pathology and sample size, in order to present a synoptic vision of the argument. Since the association between Huntington’s disease and psychiatric symptoms was demonstrated, we argue that the prevalent and more invalidating psychiatric components should be recognized as early as possible during the disease course in order to best address psychopharmacological therapy, improve quality of life, and also reduce burden on caregivers.

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“…1,[5][6][7][8] Individuals in early stages of HD are often reported to present with a variety of psychiatric manifestations including depression, anxiety, irritability, and apathy. [9][10][11][12][13][14] It has been reported that 24% to 79% of patients with HD present with psychiatric symptoms as the first manifestation of disease. 15 Although HD is characterized by this triad of symptoms, in clinical practice, patients are typically only diagnosed with HD once chorea is present and motor signs are prominent.…”

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confidence: 99%

Specific Psychiatric Manifestations Among Preclinical Huntington Disease Mutation Carriers

Marshall¹,

White²,

Weaver³

et al. 2007

Arch Neurol

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Background: Despite the need for significant clinical intervention owing to the psychiatric manifestations of Huntington disease (HD), there has been a paucity of studies specifically designed to evaluate these symptoms prior to disease diagnosis.Objectives: To investigate whether the Symptom Checklist 90-Revised (SCL-90-R) and the Center for Epidemiological Studies Depression Scale can be used to detect psychiatric manifestations among preclinical mutation carriers with absent or minimal motor signs of HD.

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Huntington's Disease and Its Association with Psychopathology

Cited by 31 publications

References 0 publications

The neural bases of obsessive–compulsive disorder in children and adults

The neural bases of obsessive–compulsive disorder in children and adults

Neuropsychiatric Burden in Huntington’s Disease

Specific Psychiatric Manifestations Among Preclinical Huntington Disease Mutation Carriers

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