Huntington's Disease: Improvement with an Anticoagulant‐Psychotherapy Regimen

Walsh, Arthur C.; Melaney, Catherine

doi:10.1111/j.1532-5415.1978.tb01222.x

Cited by 9 publications

(1 citation statement)

References 7 publications

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“…The management of these problems, from a behavioral viewpoint, is not specific to Huntington's disease and involves the same environmental restrictions and general supportive care administered to other psychotic or demented patients. It has been suggested that psychotherapy aimed specifically at allaying anxiety and reducing stress may improve cerebral blood flow and thereby abate chorea (25). Huntington's disease, however, appears to be a primary neurodegenerative disorder and there is little evidence to support a hypothesis for vascular insufficiency in the striatum (26).…”

Section: Psychiatric Therapymentioning

confidence: 99%

Huntington's Disease: Current Concepts of Therapy*

Goetz

Weiner

1979

J American Geriatrics Society

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Huntington's disease (Huntington's chorea), a degenerative disorder of the central nervous system, is inherited in an autosomal dominant pattern. Since there is no cure for this genetic disorder, therapy has been focused on pharmacologic manipulation of the involved neurotransmitter systems. In Huntington's disease, there is a functional predominance of striatal dopaminergic activity over antagonist cholinergic and possibly GABA-minergic systems. Many dopaminergic antagonists and cholinergic and GABA-minergic agonists are currently used in treatment. Supportive psychiatric care for affected persons and their families is an important therapeutic adjunct in the management of Huntington's disease. The eventual therapy will depend upon accurate identification of the primary genetic defect.

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Section: Psychiatric Therapymentioning

confidence: 99%