Huperzine A from Huperzia species—An ethnopharmacolgical review

Ma, Xiaoqiang; Tan, Chang‐Heng; Zhu, Da‐Yuan; Gang, David R.; Xiao, Pei‐Gen

doi:10.1016/j.jep.2007.05.030

Cited by 256 publications

(192 citation statements)

References 161 publications

(201 reference statements)

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“…ex Schrank et Mart., a source of huperzine A (HupA) and other alkaloids commonly known as fir club moss (family Huperziaceae), is a plant of great interest that is used in combating a wide variety of diseases in European and Asian countries [30,32,48]. Plants of the species Diphasiastrum complanatum (L.) Holub (Lycopodiaceae) are rich in alkaloids, mostly lycopodine and its derivatives, generally biologically not yet investigated [30].…”

Section: Introductionmentioning

confidence: 99%

“…Studies on the pharmacological properties of HupA are being conducted in many centres worldwide, and a comprehensive review of them has been published by Zhang and Tang [60] and Ma et al [32]. Moreover, studies by Szypuła et al [46][47][48] have shown that H. selago is a rich source of HupA and other alkaloids, which are much more abundant in this plant than in the Chinese club moss H. serrata.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Original article Assessment of antioxidative activity of alkaloids from Huperzia selago and Diphasiastrum complanatum using in vitro systems

Czapski¹,

Szypuła²,

Kudlik³

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Original article Assessment of antioxidative activity of alkaloids from Huperzia selago and Diphasiastrum complanatum using in vitro systems

Czapski¹,

Szypuła²,

Kudlik³

et al. 2014

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“…HupA is selectively potent and reversible inhibitor with a bet ter therapeutic index than physostigmine and tacrine. 32 In fact, HupA is clinically prescribed in China for symptomatic treatment of AD. In spite of their excellent AChEinhibition capacity, the above drugs have serious side effects such as Nausea, vomiting, diarrhea, weight loss, loss of appetite and muscle weakness.…”

Section: Discussionmentioning

confidence: 99%

Screening Indigenous Medicinal Plants of Northeast India for Their Anti-Alzheimer’s Properties

Sobhani¹,

Pal²,

Bhattacharjee³

et al. 2016

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Introduction:Alzheimer's disease (AD) is a progressive neurologic disease of the brain that affects intellectual abilities, reasoning and memory. Acetylcholine (ACh) is involved in the maintenance of cognitive process. Pathologically, ACh production is compromised in the brains of AD affected people. Presence of acetylcholinesterase (AChE) in the synaptic cleft, which hydrolyzes ACh, further decreases the ACh-levels, and thereby, additionally compromises cognition. The tribal people of North East India have been using indigenous plants as traditional medicine for brain disorders. We assayed whether the plants used in the traditional tribal knowledge for the treatment of brain disorders might contain better AChE-inhibitors. Methods: We collected 10 traditional medicinal plants from Northeast India. A total of 39 plant extracts were prepared using three solvent systems. The Acetylcholinesterase (AChE) activity was measured with Ellman method. The experiment was done in triplicate for each level of inhibitor. The activity was measured at 412 nm wavelength using Plate Reader. The standard student t-test was used to show significant difference in IC50 values between extracts. Results: The result are reported based on Km, Vmax, IC 50 (µg/µl), percentage inhibition and inhibition pattern. Two extracts had competitive inhibition, 11 extracts had mixed inhibition, 2 extracts had non-competitive inhibition, 11 extracts had uncompetitive inhibition and 4 extracts did not provide any proper pattern. The IC 50 for these plant extracts were at the range of 0.51-12.4 µg/µl. Notably, Cinnamomum camphora (leaf: chloroform), Litsea glutinosa (stem; chloroform), and Litsea glutinosa (stem; methanol) showed IC 50 values of 0.51, 0.53 & 0.81 µg/µl, respectively.

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“…Huperzine A obtained from Huperzia species and other members of the Lycopodiaceae, has been shown to improve memory in animals. Huperzia quadrifariata and Huperzia reflexa were also found to cure Alzheimer's disease (Ma and Gang, 2004;Ma et al, 2007;Singh and Singh, 2010;Konrath et al, 2012;Yang et al, 2012). Amentoflavone and ginkgetin, flavonoids found in Selaginella, display neurodefensive activity against cytotoxic stress, which suggests their promising usage to cure neurodegenerative diseases such as stroke and Alzheimer's (Kang et al, 2004).…”

Section: Activity Against Alzheimer's Disease and Brain Illnessmentioning

confidence: 99%

A review of the use of pteridophytes for treating human ailments

Xavier-ravi

Vigila

Zhang

et al. 2018

J. Zhejiang Univ. Sci. B

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Abstract:The aim of this review was to explore the pharmacological activity of early tracheophytes (pteridophytes) as an alternative medicine for treating human ailments. As the first vascular plants, pteridophytes (aka, ferns and fern allies) are an ancient lineage, and human beings have been exploring and using taxa from this lineage for over 2000 years because of their beneficial properties. We have documented the medicinal uses of pteridophytes belonging to thirty different families. The lycophyte Selaginella sp. was shown in earlier studies to have multiple pharmacological activity, such as antioxidant, anti-inflammatory, anti-cancer, antidiabetic, antiviral, antimicrobial, and anti-Alzheimer properties. Among all the pteridophytes examined, taxa from the Pteridaceae, Polypodiaceae, and Adiantaceae exhibited significant medicinal activity. Based on our review, many pteridophytes have properties that could be used in alternative medicine for treatment of various human illnesses. Biotechnological tools can be used to preserve and even improve their bioactive molecules for the preparation of medicines against illness. Even though several studies have reported medicinal uses of ferns, the possible bioactive compounds of several pteridophytes have not been identified. Furthermore, their optimal dosage level and treatment strategies still need to be determined. Finally, the future direction of pteridophyte research is discussed.

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Huperzine A from Huperzia species—An ethnopharmacolgical review

Cited by 256 publications

References 161 publications

Original article Assessment of antioxidative activity of alkaloids from Huperzia selago and Diphasiastrum complanatum using in vitro systems

Original article Assessment of antioxidative activity of alkaloids from Huperzia selago and Diphasiastrum complanatum using in vitro systems

Screening Indigenous Medicinal Plants of Northeast India for Their Anti-Alzheimer’s Properties

A review of the use of pteridophytes for treating human ailments

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