Nat. Prod. Rep.
 2024
DOI: 10.1039/d3np00029j
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Huperzine alkaloids: forty years of total syntheses

Bichu Cheng,
Lili Song,
Fener Chen

Abstract: This review discusses the synthetic chemistry of huperzine A, a potent inhibitor of acetylcholine esterase (AChE), followed by the advancements in other alkaloids of the family. The analogs and medicinal chemistry of huperzines are summarized.

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