Huzhang Tongfeng Granule Improves Monosodium Urate‐Induced Inflammation of Gouty Arthritis Rat Model by Downregulation of Cyr61 and Related Cytokines

Zhou, Mei; Ze, Kan; Wang, Yifei; Li, Xin; Hua, Liang; Lu, Yi; Chen, Xi; Ding, Xiaojie; Chen, Siting; Ru, Yi; Zhang, Ming; Li, Bin

doi:10.1155/2020/9238797

Cited by 17 publications

(20 citation statements)

References 31 publications

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“…DC., Coix lacrymajobi L.var.ma-yuen (Roman.) Stapf (Yi Yi), Cyathula officinalis Kuan (Xiang et al, 2009;Zhang et al, 2009;Zhang et al, 2011;Zhou et al, 2013;Xie et al, 2017;Yu et al, 2018). The specific doses of herbs in each study have been listed in the Supplementary Tables S4-S6.…”

Section: Discussionmentioning

confidence: 99%

“…Of the 10 included trials, nine were treated with herbal formula, and the remaining one was treated with a combination of herbal extracts and active ingredients. In the subgroup analyses of intervention, two studies compared the therapeutic effects of Chinese herbal medicine and placebo (Rozza et al, 2016;Xie et al, 2017), three studies compared Chinese herbal medicine and Western medicine (Zhang et al, 2009;Zhou et al, 2013;Wang et al, 2014), two studies compared Chinese herbal medicine, Western medicine and placebo or no intervention (Zhang et al, 2011;Wang et al, 2019b), one compared two kinds of Chinese herbal medicine and Western medicine (Yu et al, 2018), and two compared Chinese herbal medicine combined Western medicine and Western medicine (Chen et al, 2009;Xiang et al, 2009).…”

Section: Study Characteristicsmentioning

confidence: 99%

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The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review

et al. 2021

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Background. Chinese herbal medicines are widely used to lower serum uric acid levels. However, no systemic review summarizes and evaluates their efficacies and the underlying mechanisms of action. Objectives. To evaluate the clinical and experimental evidences for the effectiveness and the potential mechanism of Chinese herbal medicines in lowering serum uric acid levels. Methods. Four electronic databases PubMed, Wed of Science, the Cochrane Library and Embase were used to search for Chinese herbal medicines for their effects in lowering serum uric acid levels, dated from 1 January 2009 to 19 August 2020. For clinical trials, randomized controlled trials (RCTs) were included; and for experimental studies, original articles were included. The methodological quality of RCTs was assessed according to the Cochrane criteria. For clinical trials, a meta-analysis of continuous variables was used to obtain pooled effects. For experimental studies, lists were used to summarize and integrate the mechanisms involved. Results. A total of 10 clinical trials and 184 experimental studies were included. Current data showed that Chinese herbal medicines have promising clinical efficacies in patients with elevated serum uric acid levels (SMD: −1.65, 95% CI: −3.09 to −0.22; p = 0.024). There was no significant difference in serum uric acid levels between Chinese herbal medicine treatments and Western medicine treatments (SMD: −0.13, 95% CI: −0.99 to 0.74; p = 0.772). Experimental studies revealed that the mechanistic signaling pathways involved in the serum uric acid lowering effects include uric acid synthesis, uric acid transport, inflammation, renal fibrosis and oxidative stress. Conclusions. The clinical studies indicate that Chinese herbal medicines lower serum uric acid levels. Further studies with sophisticated research design can further demonstrate the efficacy and safety of these Chinese herbal medicines in lowering serum uric acid levels and reveal a comprehensive picture of the underlying mechanisms of action.

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Section: Discussionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review

et al. 2021

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“…Gout is a common metabolic disease and AGA is one of the important complications 14 . AGA is a group of clinical syndromes caused by MSU crystal deposition on bone, joints, and subcutaneous tissues, which is the most common initial symptom of gout 15 . It is worth noting that while hyperuricemia has been classically associated with gouty arthritis, asymptomatic hyperuricemia is frequently found in metabolic syndrome, diabetes mellitus, chronic kidney disease, and osteoarthritis 16,17 .…”

Section: Discussionmentioning

confidence: 99%

“…14 AGA is a group of clinical syndromes caused by MSU crystal deposition on bone, joints, and subcutaneous tissues, which is the most common initial symptom of gout. 15 It is worth noting that while hyperuricemia has been classically associated with gouty arthritis, asymptomatic hyperuricemia is frequently found in metabolic syndrome, diabetes mellitus, chronic kidney disease, and osteoarthritis. 16,17 Osteoarthritis is the most common form of arthritis overall, and gout and osteoarthritis frequently coexist in the same patient.…”

Section: Discussionmentioning

confidence: 99%

MiR‐221‐5p is involved in the regulation of inflammatory responses in acute gouty arthritis by targeting IL‐1β

Zhang

et al. 2020

Int J of Rheum Dis

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Background: Gout is caused by the accumulation of deposited sodium urate (MSU) crystals in the joints. Recent studies have shown that interleukin-1β (IL-1β) is a key in ammatory mediator of acute gouty arthritis(AGA), and its level is regulated by microRNAs (miRNAs). However, the molecular mechanism of its regulation is still unclear. Methods: 100 patients with AGA and 94 healthy individuals were recruited. The expression of serum miR-221-5p was determined by qRT-PCR. The receiver operating curve (ROC) was applied for diagnostic value analysis. A luciferase reporter assay was performed to con rm the interaction of miRNA and the 3'untranslated region (UTR) of IL-1β. ELISA was used to detect serum and proin ammatory factors. Results: miR-221-5p was lower expressed in the serum of AGA patients. The AUC was 0.884, the sensitivity was 82.0%, and the speci city was 80.9%. Serum miR-221-5p was negatively correlated with the expression levels of VAS and IL-1β. Cell experiments showed that overexpression of miR-221-5p signi cantly inhibited the expression of in ammatory factors tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), and IL-1β, while down-regulation of miR-221-5p was the opposite. Luciferase analysis showed that IL-1β was the target gene of miR-221-5p. Conclusions: This study con rmed that miR-221-5p regulates the production of in ammatory cytokines during the pathogenesis of AGA. These results suggest that miR-221-5p can be used as potential therapeutic targets for the treatment of AGA.

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“…Furthermore, CCN1 was shown to induce expression and secretion of the inflammatory cytokines IL-1β, TNF-α, and IL-6, and inhibition of CCN1 expression suppressed the actions of these cytokines and attenuated inflammation [ 26 ]. Thus, CCN1-induced production/secretion of these inflammatory cytokines might constitute the basis of the enhanced inflammation in various organs, including the lung, gut, and CNS, and cytokine storms [ 27 ] associated with COVID-19.…”

Section: Main Textmentioning

confidence: 99%

Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders

Kase

Okano

2020

Inflamm Regener

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It has been reported that coronavirus disease 2019 (COVID-19) causes not only pneumonia but also systemic inflammations including central nervous system (CNS) disorders. However, little is known about the mechanism that triggers the COVID-19-associated CNS disorders, due to the lack of appropriate experimental systems. Our present study showed that angiotensin-converting enzyme-2 (ACE2), a cellular receptor for SARS-CoV-2, is expressed in human induced pluripotent stem cell (iPSC)-derived neural stem/progenitor cells (hiPSC-NS/PCs) and young neurons. Furthermore, together with database analysis, we found that a viral virulent factor CCN family member 1 (CCN1), which is known to be induced by SARS-CoV-2 infection, is expressed in these cells at basal levels. Considering the role of CCN1 which is known to be involved in viral toxicity and inflammation, hiPSC-NS/PCs could provide an excellent model for COVID-19-associated CNS disorders from the aspect of SARS-CoV-2 infection-ACE2-CCN1 axis. In addition, we identified compounds that reduce CCN1 expression. Collectively, our study using hiPSC-NS/PCs may aid in the development of a therapeutic target for COVID-19-related CNS disorders.

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Huzhang Tongfeng Granule Improves Monosodium Urate‐Induced Inflammation of Gouty Arthritis Rat Model by Downregulation of Cyr61 and Related Cytokines

Cited by 17 publications

References 31 publications

The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review

The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review

MiR‐221‐5p is involved in the regulation of inflammatory responses in acute gouty arthritis by targeting IL‐1β

Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders

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