HVT-vectored H7 vaccine protects chickens from lethal infection with the highly pathogenic H7N9 Avian inﬂuenza virus

Chen, Yi-qun; Su, Guan-ming; Zhang, Jia-hao; Li, Bo; Ma, Kai-xiong; Zhang, Xu; Huang, Li-hong; Liao, Ming; Qi, Wen-bao

doi:10.1016/j.vetmic.2023.109852

Veterinary Microbiology

2023

DOI: 10.1016/j.vetmic.2023.109852

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HVT-vectored H7 vaccine protects chickens from lethal infection with the highly pathogenic H7N9 Avian inﬂuenza virus

Yi-qun Chen,

Guan-ming Su,

Jia-hao Zhang

et al.

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2024

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Current Status of Poultry Recombinant Virus Vector Vaccine Development

Wang,

Tian,

Zhao

et al. 2024

Vaccines

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Inactivated and live attenuated vaccines are the mainstays of preventing viral poultry diseases. However, the development of recombinant DNA technology in recent years has enabled the generation of recombinant virus vector vaccines, which have the advantages of preventing multiple diseases simultaneously and simplifying the vaccination schedule. More importantly, some can induce a protective immune response in the presence of maternal antibodies and offer long-term immune protection. These advantages compensate for the shortcomings of traditional vaccines. This review describes the construction and characterization of primarily poultry vaccine vectors, including fowl poxvirus (FPV), fowl adenovirus (FAdV), Newcastle disease virus (NDV), Marek’s disease virus (MDV), and herpesvirus of turkey (HVT). In addition, the pathogens targeted and the immunoprotective effect of different poultry recombinant virus vector vaccines are also presented. Finally, this review discusses the challenges in developing vector vaccines and proposes strategies for improving immune efficacy.

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Current Status of Poultry Recombinant Virus Vector Vaccine Development

Wang,

Tian,

Zhao

et al. 2024

Vaccines

View full text Add to dashboard Cite

show abstract

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HVT-vectored H7 vaccine protects chickens from lethal infection with the highly pathogenic H7N9 Avian inﬂuenza virus

Cited by 1 publication

References 38 publications

Current Status of Poultry Recombinant Virus Vector Vaccine Development

Current Status of Poultry Recombinant Virus Vector Vaccine Development

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