Hyaline membrane disease in the newborn: Diagnosis by ultrasound

Avni, Efraim; Braude, Philippe; Pardou, Anne; Matos, Celso

doi:10.1007/bf02012957

Cited by 46 publications

(45 citation statements)

References 6 publications

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“…It has shown a significant correlation with extravascular lung water in both adults [16,17] and neonates [18]. Avni et al [19 ]described lung retrohepatic anomalies at abdominal ultrasonography in newborns with RDS, but evaluation by the transabdominal approach cannot show lung apex involvement and pleural changes that are essential to distinguish RDS from TTN [7]. We previously described the specific LUS findings in neonates with RDS [6] or TTN [7] through the transthoracic approach.…”

Section: Discussionmentioning

confidence: 99%

Lung Ultrasound Accuracy in Respiratory Distress Syndrome and Transient Tachypnea of the Newborn

et al. 2014

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Background: Lung ultrasound (LUS) is a promising technique for the diagnosis of neonatal respiratory diseases. Preliminary data has shown a good sensitivity and specificity of LUS in the diagnosis of respiratory distress syndrome (RDS) and transient tachypnea of the newborn (TTN). Objective: The aim of this study was to calculate the sensitivity, specificity, and negative (NPV) and positive predictive value (PPV) of LUS for RDS and TTN, using an external reader blinded to the clinical condition. Design and Methods: Neonates with respiratory distress had a LUS within 1 h of admission. Images were uploaded and sent to the external reader, who made the ultrasound diagnosis according to the appearance of the images. The final clinical diagnosis was made according to all the available data, except LUS data. Sensitivity, specificity, PPV, and NPV were calculated considering the final clinical diagnosis as the gold standard. Results: Fifty-nine neonates were studied (mean gestational age: 33 ± 4 weeks, mean birth weight: 2,145 ± 757 g). Twenty-three infants had a final diagnosis of RDS and 30 of TTN. LUS showed a sensitivity of 95.6% and specificity of 94.4%, with a PPV of 91.6% and a NPV of 97.1% for RDS, and a sensitivity of 93.3% and specificity of 96.5% with a PPV of 96.5% and a NPV of 93.4% for TTN. Conclusions: LUS showed high sensitivity and specificity in diagnosing RDS and TTN.

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Section: Discussionmentioning

confidence: 99%

Lung Ultrasound Accuracy in Respiratory Distress Syndrome and Transient Tachypnea of the Newborn

et al. 2014

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“…In a few studies lung ultrasound also has been evaluated in newborns. Avni et al [18,19] and Pieper et al [20] used ultrasonography to diagnose hyaline membrane disease [18] and to predict the development of bronchopulmonary dysplasia [19,20] . These authors, however, utilized only an abdominal approach and ultrasound was not adopted as a routine method of assessing neonatal respiratory disorders.…”

Section: Discussionmentioning

confidence: 99%

The ‘Double Lung Point’: An Ultrasound Sign Diagnostic of Transient Tachypnea of the Newborn

Copetti¹,

2006

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Background: Transient tachypnea of the newborn (TTN) is a mild form of neonatal respiratory distress which early in its course needs to be differentiated from other severe respiratory disorders. At present the diagnosis is based on radiological findings and clinical course. Lung sonography in TTN has not yet been assessed. Objectives: The aim of the study was to define the ultrasonographic appearance of TTN and evaluate its clinical relevance. Methods: Lung sonography was performed in 32 newborn infants with radiological and clinical signs of TTN within the first hour after birth and the findings were compared with those of 60 normal infants, 29 with respiratory distress syndrome, 6 with pneumonia, 5 with pulmonary hemorrhage and 5 with atelectasis. Results: In the infants with TTN, lung sonography showed a difference in lung echogenicity between the upper and lower lung areas. There were very compact comet-tail artifacts in the inferior fields while these were rare in the superior fields. We designated this finding the ‘double lung point’ and it was not observed in healthy infants, infants with respiratory distress syndrome, actelectasis, pneumothorax, pneumonia, or pulmonary hemorrhage. Sensitivity and specificity of the double lung point was 100% for the diagnosis of TTN. Conclusion: We found lung sonography reliable for the early diagnosis of TTN. We suggest that it should become the first approach for imaging of neonatal respiratory distress although further prospective studies with good blinding need to be performed.

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“…Trans-abdominal US examination of the lung bases is based on the acoustic phenomenon of "mirror image" (11,12). The ultrasound waves which are transmitted through the tissues are subject to reverberation (reflection), refraction, dispersion and absorption.…”

Section: Discussionmentioning

confidence: 99%

“…1), which is based on the "mirror image" phenomenon (11,12). The criteria for abnormal ultrasound findings within the pulmonary bases were: the existence of a consolidation of the lung parenchyma, pleural effusion, alveolar-interstitial edema (area of compact B lines), or combinations thereof.…”

Section: Methodsmentioning

confidence: 99%

Abdominal ultrasound in children - are we careful enough when it comes to lung bases?

et al. 2016

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Objective -To investigate the frequency of positive findings within the lung bases during abdominal ultrasound (US) examinations in children with referral diagnosis not suggesting pulmonary disease. Materials and methods -A retrospective study included all children with abdominal US performed within 2 years by a single pediatric radiologist in the regional children's hospital. Of all examined children, 22 (mean 7.4 y, SD=4.2 y) had pathological findings detected within the lung bases, without referral diagnosis suggesting a pulmonary pathology. Each abdominal US included a trans-abdominal (trans-hepatic and trans-splenic) approach to both lung bases. Results -While performing abdominal US a detected pulmonary pathology included: 19 pneumonias and 3 pleuropneumonias, with the most common referral diagnosis being abdominal pain (15 children), followed by nausea and vomitting (3 children), febrile convulsiones (2 children), exacerbation of juvenile arthritis (1), and a routine follow-up a day after hydrostatic reduction of ileocolic intussusception (1). In outpatients with referral diagnosis of abdominal pain, 0.95% had positive lung base US findings. Conclusion -Each radiologist should be aware of the potential pathological finding within the lung bases when performing abdominal ultrasound in children. Its detection might have a serious impact on the patient's treatment.

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Hyaline membrane disease in the newborn: Diagnosis by ultrasound

Cited by 46 publications

References 6 publications

Lung Ultrasound Accuracy in Respiratory Distress Syndrome and Transient Tachypnea of the Newborn

Lung Ultrasound Accuracy in Respiratory Distress Syndrome and Transient Tachypnea of the Newborn

The ‘Double Lung Point’: An Ultrasound Sign Diagnostic of Transient Tachypnea of the Newborn

Abdominal ultrasound in children - are we careful enough when it comes to lung bases?

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