Hyaline Vascular Type of Unicentric Castleman Disease in a Kidney with End-Stage Renal Disease: A Case Report of a Rare Entity at an Unusual Location and a Special Clinical Setting

Chen, Chuan-Han; Li, Hsin-Ni

doi:10.3390/diagnostics12112878

Cited by 2 publications

(2 citation statements)

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“…Similarly, in the case of the UCD hyaline vascular variant reported by Chen C. and Hsin-Ni Li, the initial investigations included an ultrasound followed by a CT and further MRI, which was not done in our patient. Immunohistochemical analysis in this case reported positive CD20 and CD21 with negative CD3 and Bcl-2 in contrast to our findings (CD20+, CD5+, CD21+, CD34+) [9].…”

Section: Discussioncontrasting

confidence: 99%

The Role of Radiation Therapy in Unicentric Castleman Disease: A Case Report

Rodriguez,

Rivera Rubi,

Menjivar

et al. 2023

Cureus

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Castleman disease (CD) is a rare lymphoproliferative disorder characterized by localized (unicentric) or systemic (multicentric) lymphadenopathy. This study presents a unique case of a 29-year-old female with a rare pelvic presentation of unicentric Castleman disease, specifically the hyaline vascular variant. Despite surgical resection, an unresectable residual lesion prompted adjuvant radiotherapy and subsequent chemotherapy. The literature highlights surgical resection as the primary treatment for localized Castleman disease; however, radiotherapy and combined chemotherapy regimens like cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) have shown promise in unresectable cases, emphasizing a multidisciplinary approach. This case underscores the importance of tailoring treatment strategies for uncommon Castleman disease presentations.

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Section: Discussioncontrasting

confidence: 99%

The Role of Radiation Therapy in Unicentric Castleman Disease: A Case Report

Rodriguez,

Rivera Rubi,

Menjivar

et al. 2023

Cureus

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“…При мультицентрической форме манифестирование в большинстве случаев происходит в 50-60 лет, в ряде случаев имеется вторичное поражение почек и лёгких, паранеопластическая пузырчатка, периферическая нейропатия. Лабораторно выявляются анемия, тромбоцитоз, гипергаммаглобулинемия, повышенный С-реактивный белок [9][10][11][12].…”

Section: Introductionunclassified

Castleman disease. A rare clinical case of retroperitoneal tumor localization in an elderly patient

Polyanskiy,

Zvyagin,

Petrik

et al. 2023

Acta biomedica scientifica

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Castleman disease is an extremely rare benign disease of the lymphatic system with an estimated incidence of 1–9 cases per 1,000,000. Its etiology remains unknown; interleukin 6 (IL-6) plays an important role in pathogenesis. Castleman disease has two clinical forms: localized (up to 90 % of cases) with a favorable prognosis, treated predominantly by surgical method; generalized (up to 10 % of cases) with less favorable prognosis, treated by pharmacological therapy. The diagnosis is rarely established at the preoperative stage.The aim. To present a clinical case of diagnosis and treatment of Castleman tumor of a rare topical localization.Results. A 66-year-old patient was admitted at the Abdominal Oncology Department of the G.E. Ostroverkhov Kursk Oncology Scientific and Clinical Center.Diagnosis: Retroperitoneal mass on the right found at the preventive examination; no peripheral lymphadenopathy was detected on ultrasound and computed tomography (CT). After the examination, a preliminary diagnosis was made: Gastrointestinal stromal tumor (GIST) of the small intestine mesentery. Based on the results of the case conference, the decision was taken to perform a surgery – laparoscopic removal of the tumor under endotracheal anesthesia. For surgical approach, a fan-shaped arrangement of ports was chosen. The surgery had no complications. Intraoperative blood loss was 50.0 ml. The total operating time was 98 minutes.According to the results of the histological study, the following diagnosis was made: Castleman disease, unicentric form, hyaline-vascular variant. En bloc surgery is the standard method for the treatment of localized forms of the Castleman disease. In all cases, long-term follow-up shows a long relapse-free period in almost all patients.During follow-up examinations (ultrasound of the abdominal cavity and retroperitoneal space, CT of the abdominal cavity with contrast enhancement, CT of the chest), no disease recurrence was detected during the year of observation.Castleman disease is a rare non-clonal lymphoproliferative disease of unknown etiology. A rare case of its retroperitoneal localization indicates that in cases with an uncertain nature of the peritoneal mass, Castleman disease should be included in the differential diagnostic search.

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Hyaline Vascular Type of Unicentric Castleman Disease in a Kidney with End-Stage Renal Disease: A Case Report of a Rare Entity at an Unusual Location and a Special Clinical Setting

Cited by 2 publications

References 31 publications

The Role of Radiation Therapy in Unicentric Castleman Disease: A Case Report

The Role of Radiation Therapy in Unicentric Castleman Disease: A Case Report

Castleman disease. A rare clinical case of retroperitoneal tumor localization in an elderly patient

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