Hyaluronan Biology in Vocal Fold Morphology and Biomechanics

Thibeault, Susan L.

doi:10.1016/b978-008044382-9/50047-9

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Hyaluronan1

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Cited by 4 publications

(1 citation statement)

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“…18 It has been shown that if HA is removed from the vocal folds, there is an increase in viscosity and a reduction in stiffness of the tissue, which creates less than optimal conditions for phonation and vocal fundamental frequency. 20,21 In general, men have a higher concentration of HA in the vocal folds than do women. 22 Levels of HA in the vocal folds may have an impact on wound healing and scar formation.…”

Section: Hyaluronanmentioning

confidence: 98%

Current Understanding and Review of the Literature: Vocal Fold Scarring

Hansen¹,

Thibeault²

2006

Journal of Voice

Self Cite

178

187

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Section: Hyaluronanmentioning

confidence: 98%

Current Understanding and Review of the Literature: Vocal Fold Scarring

Hansen¹,

Thibeault²

2006

Journal of Voice

Self Cite

178

187

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Vocal Fold Tissue Repairin VivoUsing a Synthetic Extracellular Matrix

Duflo¹,

Thibeault²,

Li³

et al. 2006

Tissue Engineering

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Tissue Engineering Therapies for the Vocal Fold Lamina Propria

Kutty

Webb

2009

Tissue Engineering Part B: Reviews

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The vocal folds are laryngeal connective tissues with complex matrix composition/organization that provide the viscoelastic mechanical properties required for voice production. Vocal fold injury results in alterations in tissue structure and corresponding changes in tissue biomechanics that reduce vocal quality. Recent work has begun to elucidate the biochemical changes underlying injury-induced pathology and to apply tissue engineering principles to the prevention and reversal of vocal fold scarring. Based on the extensive history of injectable biomaterials in laryngeal surgery, a major focus of regenerative therapies has been the development of novel scaffolds with controlled in vivo residence time and viscoelastic properties approximating the native tissue. Additional strategies have included cell transplantation and delivery of the antifibrotic cytokine hepatocyte growth factor, as well as investigation of the effects of the unique vocal fold vibratory microenvironment using in vitro dynamic culture systems. Recent achievements of significant reductions in fibrosis and improved recovery of native tissue viscoelasticity and vibratory/functional performance in animal models are rapidly moving vocal fold tissue engineering toward clinical application.

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Hyaluronan Biology in Vocal Fold Morphology and Biomechanics

Cited by 4 publications

References 33 publications

Current Understanding and Review of the Literature: Vocal Fold Scarring

Current Understanding and Review of the Literature: Vocal Fold Scarring

Vocal Fold Tissue Repairin VivoUsing a Synthetic Extracellular Matrix

Tissue Engineering Therapies for the Vocal Fold Lamina Propria

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