Hyaluronan derivative decorated calcium carbonate nanoparticle as a potential platform for breast cancer synergistic therapy via blood coagulation and drug delivery

Zhou, Fei; Li, Huiru; Liu, Yuying; Deng, Hongkuan; Rong, Jianhua; Zhao, Jianhao

doi:10.1016/j.jddst.2023.104406

Cited by 5 publications

(3 citation statements)

References 55 publications

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“…As an extension of the precipitation method, the microemulsion method is widely used in the preparation of CaCO 3 NPs and gene encapsulation. The microemulsion method includes water-in-oil (W/O) reverse microemulsion method and double microemulsion method. , The reverse microemulsion uses W/O microemulsion droplets as a nanoreactor . First, “calcium microemulsion” and “carbonate microemulsion” are prepared by adding a Ca 2+ or CO 3 2– aqueous phase to the organic phase, respectively.…”

Section: Synthesis Of Caco3-based Nanoplatformsmentioning

confidence: 99%

Calcium Carbonate-Based Nanoplatforms for Cancer Therapeutics: Current State of Art and Future Breakthroughs

Zhou,

Wang,

Lei

et al. 2024

ACS Omega

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With the rapid development of nanotechnology, nanomaterials have shown immense potential for antitumor applications. Nanosized calcium carbonate (CaCO 3 ) materials exhibit excellent biocompatibility and degradability, and have been utilized to develop platform technologies for cancer therapy. These materials can be engineered to carry anticancer drugs and functional groups that specifically target cancer cells and tissues, thereby enhancing therapeutic efficacy. Additionally, their physicochemical properties can be tailored to enable stimuli-responsive therapy and precision drug delivery. This Review consolidates recent literatures focusing on the synthesis, physicochemical properties, and multimodal antitumor therapies of CaCO 3based nanoplatforms (CBN). We also explore the current challenges and potential breakthroughs in the development of CBN for antitumor applications, providing a valuable reference for researchers in the field.

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Section: Synthesis Of Caco3-based Nanoplatformsmentioning

confidence: 99%

Calcium Carbonate-Based Nanoplatforms for Cancer Therapeutics: Current State of Art and Future Breakthroughs

Zhou,

Wang,

Lei

et al. 2024

ACS Omega

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“…In recent years, drug delivery systems constructed using CCNM biomaterials have been widely studied, but the concentration of drugs delivered is limited and cannot achieve clinically effective concentrations, which cannot achieve the desired clinical effects. Some studies have shown that various molecular adjuvants, such as biopolymers or synthetic polymers, can be added to the CCNM to load more drugs and make the drug release more slowly ( Zhou et al, 2023 ).…”

Section: The Challenges and Recommendations For Future Studies Of Ccnmmentioning

confidence: 99%

Research progress of calcium carbonate nanomaterials in cancer therapy: challenge and opportunity

Liang,

Feng,

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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Cancer has keeping the main threat to the health of human being. Its overall survival rate has shown rare substantial progress in spite of the improving diagnostic and treatment techniques for cancer in recent years. Indeed, such classic strategies for malignant tumor as surgery, radiation and chemotherapy have been developed and bring more hope to the patients, but still been accompanied by certain limitations, which include the challenge of managing large wound sizes, systemic toxic side effects, and harmful to the healthy tissues caused by imprecise alignment with tumors in radiotherapy. Furthermore, immunotherapy exhibits a limited therapeutic effect in advanced tumors which is reported only up to 25%–30%. The combination of nanomaterials and cancer treatment offers new hope for cancer patients, demonstrating strong potential in the field of medical research. Among the extensively utilized nanomaterials, calcium carbonate nanomaterials (CCNM) exhibit a broad spectrum of biomedical applications due to their abundant availability, cost-effectiveness, and exceptional safety profile. CCNM have the potential to elevate intracellular Ca2+ levels in tumor cells, trigger the mitochondrial damage and ultimately lead to tumor cell death. Moreover, compared with other types of nanomaterials, CCNM exhibit remarkable advantages as delivery systems owing to their high loading capacity, biocompatibility and biodegradability. The purpose of this review is to provide an overview of CCNM synthesis, focusing on summarizing its diverse roles in cancer treatment and the benefits and challenges associated with CCNM in cancer therapy. Hoping to present the significance of CCNM as for the clinical application, and summarize information for the design of CCNM and other types of nanomaterials in the future.

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“…Application of various types of inorganic nanoparticles (NPs) is of particular interest for delivery of biologically active, against malignant tumors, compounds [1][2][3]. Food and Drug Administration (FDA) approved biomaterials are required for the synthesis of NPs.…”

Section: Introductionmentioning

confidence: 99%

Inorganic nanocarriers based on calcium carbonate and silica oxide for passive breast cancer targeting

Postovalova,

Tishchenko,

Rusakova

et al. 2024

Chim.Tech.Acta

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Nanoparticles (NPs) are widely used platforms for delivery of various biologically active compounds. Unfortunately, there is a lack of comprehensive investigations that would include a few types of NPs with different physicochemical parameters and their potential use as delivery systems in one tumor model. Therefore, to achieve therapeutic effect via nanocarrier with therapeutic agent, the properties of the developed NPs must be clearly defined. Herein, we report the development and modification of 99mTc and Cy5-labeled NPs based on calcium carbonate (CaCO3) and silica oxide (SiO2) to investigate in vitro and in vivo distribution on an example of a breast cancer model. We describe the synthesis and characterization of these NPs, including their morphology, size distribution, stability in biological media and cytotoxicity. Transmission electron microscopy (TEM), confocal laser scanning microscopy (CLSM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), direct radiometry analysis, and histology were used to collect all data. The cellular uptake of NPs on 4T1 cell linewas shown in vitro and in vivo. As a result, we demonstrated that these NPs are non-toxic, biocompatible, and stable system to use for delivery of bioactive compounds into breast cancer.

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Hyaluronan derivative decorated calcium carbonate nanoparticle as a potential platform for breast cancer synergistic therapy via blood coagulation and drug delivery

Cited by 5 publications

References 55 publications

Calcium Carbonate-Based Nanoplatforms for Cancer Therapeutics: Current State of Art and Future Breakthroughs

Calcium Carbonate-Based Nanoplatforms for Cancer Therapeutics: Current State of Art and Future Breakthroughs

Research progress of calcium carbonate nanomaterials in cancer therapy: challenge and opportunity

Inorganic nanocarriers based on calcium carbonate and silica oxide for passive breast cancer targeting

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