Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism

Zhu, Yi; Kruglikov, Ilja L.; Akgul, Yucel; Scherer, Philipp E.

doi:10.1016/j.matbio.2018.02.012

Cited by 54 publications

(36 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…UDP-glucose 6-dehydrogenase is an extracellular matrix enzyme responsible for the synthesis of hyaluronan (HA) and is important for tissue organization, development, and cell proliferation (34). Given that hyaluronan is a major component of the adipose tissue ECM and affects adipogenesis and adipose tissue function (35), we speculate that UDP-glucose 6-dehydrogenase mediates these effects via hyaluronan in NE-treated brown adipocytes. On the other hand, IGF2, a fetal mitogen, showed a fivefold higher secretion in white adipocytes in the basal state ( Fig.…”

Section: The Secretory Response Between Ne-stimulated and Basal Statementioning

confidence: 99%

Comparative Secretome Analyses of Primary Murine White and Brown Adipocytes Reveal Novel Adipokines

Khan

Hansson

Weber

et al. 2018

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

The adipose organ, including white and brown adipose tissues, is an important player in systemic energy homeostasis, storing excess energy in form of lipids while releasing energy upon various energy demands. Recent studies have demonstrated that white and brown adipocytes also function as endocrine cells and regulate systemic metabolism by secreting factors that act locally and systemically. However, a comparative proteomic analysis of secreted factors from white and brown adipocytes and their responsiveness to adrenergic stimulation has not been reported yet. Therefore, we studied and compared the secretome of white and brown adipocytes, with and without norepinephrine (NE) stimulation. Our results reveal that carbohydrate-metabolism-regulating proteins are preferably secreted from white adipocytes, while brown adipocytes predominantly secrete a large variety of proteins. Upon NE stimulation, an increased secretion of known adipokines is favored by white adipocytes while brown adipocytes secreted higher amounts of novel adipokines. Furthermore, the secretory response between NE-stimulated and basal state was multifaceted addressing lipid and glucose metabolism, adipogenesis, and antioxidative reactions. Intriguingly, NE stimulation drastically changed the secretome in brown adipocytes. In conclusion, our study provides a comprehensive catalogue of novel adipokine candidates secreted from white and brown adipocytes with many of them responsive to NE. Given the beneficial effects of brown adipose tissue activation on its endocrine function and systemic metabolism, this study provides an archive of novel batokine candidates and biomarkers for activated brown adipose tissue.

show abstract

Section: The Secretory Response Between Ne-stimulated and Basal Statementioning

confidence: 99%

Comparative Secretome Analyses of Primary Murine White and Brown Adipocytes Reveal Novel Adipokines

Khan

Hansson

Weber

et al. 2018

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

show abstract

“…Fat tissue is a major source for inflammatory molecules and obesity itself can be associated with elevated levels of inflammatory molecules 41 . The hyaluronic acid has a well-described role in adipogenesis 42 . We found a significant relationship between HYAL-1 levels and BMI, and HYAL-1 concentrations were higher in the obese compared to the non-obese controls.…”

Section: Discussionmentioning

confidence: 99%

The role of hyaluronic acid and hyaluronidase-1 in obstructive sleep apnoea

Mészáros

Kis

Kunos

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Biological functions of hyaluronic acid (HA) depend on its molecular size. High-molecular weight HA (HMW-HA) is an important component of the endothelial wall and has anti-inflammatory and antioxidant properties. Under inflammation or hypoxia, HMW-HA is degraded by hyaluronidases, such as HYAL-1 resulting in pro-inflammatory low-molecular weight fragments. Obstructive sleep apnoea (OSA) is characterised by intermittent hypoxia and systemic inflammation. Our aim was to evaluate circulating HMW-HA and HYAL-1 in OSA. We recruited 68 patients with OSA and 40 control volunteers. After full-night sleep study blood samples were taken for HMW-HA and HYAL-1 measurements. HYAL-1 levels were significantly higher in patients with OSA compared to controls (0.59/0.31–0.88/ng/mL vs. 0.31/0.31–0.58/ng/mL; p = 0.005) after adjustment for gender, age, BMI and smoking. There was a trend for reduced HMW-HA concentrations in OSA (31.63/18.11–59.25/ng/mL vs. 46.83/25.41–89.95/ng/mL; p = 0.068). Significant correlation was detected between circulating HMW-HA and apnoea-hypopnoea-index (r = − 0.195, p = 0.043), HYAL-1 and apnoea-hypopnoea-index (r = 0.30, p < 0.01) as well as oxygen desaturation index (r = 0.26, p < 0.01). Our results suggest that chronic hypoxia is associated with increased plasma HYAL-1 concentration and accelerated HMW-HA degradation. Altered hyaluronan metabolism may be involved in the inflammatory cascade potentially leading to endothelial dysfunction in OSA.

show abstract

“…With increasing molecular weight, viscosity, osmolality, and elasticity of the HA gel also increase. Osmolality further increased when HA is bound to sWAT (Zhu, Kruglikov, Akgul, & Scherer, 2018).…”

Section: Interaction Of Ha-fillers With White Adipose Tissuementioning

confidence: 99%

Adipose tissue, fillers, and skin tightening

Wollina

Goldman

Abdel-Naser

et al. 2018

Dermatologic Therapy

View full text Add to dashboard Cite

The role of adipose tissue has long been underestimated in esthetic dermatology. With the development of liposculpture and lipolysis, subcutaneous adipose tissue has gained an increasing interest. Harvested tissue has been used for lipofilling. In recent years, a better understanding of adipocyte physiology and its role in aging opened a new road for targeted treatments. Subcutaneous adipose tissue is no longer an innocent bystander in the combat of aging and the correction in esthetics. Adipose tissue is of importance for metabolic function and thermoregulation. Adipose tissue is involved in inflammation. Adipose tissue is heterogeneous in sense of function, color and size of adipocytes. The tissue is an important source of somatic stem cells.

show abstract

Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism

Cited by 54 publications

References 76 publications

Comparative Secretome Analyses of Primary Murine White and Brown Adipocytes Reveal Novel Adipokines

Comparative Secretome Analyses of Primary Murine White and Brown Adipocytes Reveal Novel Adipokines

The role of hyaluronic acid and hyaluronidase-1 in obstructive sleep apnoea

Adipose tissue, fillers, and skin tightening

Contact Info

Product

Resources

About