Hyaluronan mediates adhesion of metastatic colon carcinoma cells1

Laurich, Chad; Wheeler, Marie A.; Iida, Joji; Neudauer, Cheryl L.; McCarthy, James B.; Bullard, Kelli M.

doi:10.1016/j.jss.2004.05.018

Cited by 42 publications

(25 citation statements)

References 37 publications

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“…Hyaluronan is associated with the pericellular matrix surrounding proliferating and motile cells in normal and pathological systems, where it has both structural and signaling functions [262,263]. Hyaluronan enhances colorectal tumor cell proliferation and motility in vitro and in vivo [264,265]. Inhibition of hyaluronan production in SW620 colon carcinoma cells blocks matrigel invasion [266].…”

Section: Hyaluronanmentioning

confidence: 99%

The Tumor Microenvironment in Colorectal Carcinogenesis

Peddareddigari

Wang

DuBois

2010

Cancer Microenvironment

186

163

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Colorectal cancer is the second leading cause of cancer-related mortality in the United States. Therapeutic developments in the past decade have extended life expectancy in patients with metastatic disease. However, metastatic colorectal cancers remain incurable. Numerous agents that were demonstrated to have significant antitumor activity in experimental models translated into disappointing results in extending patient survival. This has resulted in more attention being focused on the contribution of tumor microenvironment to the progression of a number of solid tumors including colorectal cancer. A more complete understanding of interactions between tumor epithelial cells and their stromal elements will enhance therapeutic options and improve clinical outcome. Here we will review the role of various stromal components in colorectal carcinogenesis and discuss the potential of targeting these components for the development of future therapeutic agents.

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Section: Hyaluronanmentioning

confidence: 99%

The Tumor Microenvironment in Colorectal Carcinogenesis

Peddareddigari

Wang

DuBois

2010

Cancer Microenvironment

186

163

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“…27 HS 3 is more active and produces shorter chain length HAs while, HS 1 and 2 synthesize longer chain length HAs. 28 The role of HA in fundamental physiological and pathological process such as embryo development, 29 migration, adhesion, proliferation and differentiation of cells, [30][31][32][33][34] immune surveillance, 35 inflammation, 36 wound healing, 37 angiogenesis, malignant transformation and viscoelasticity [38][39][40][41][42] well documented, but beyond the scope of this article.…”

Section: Snake Venom Pathologymentioning

confidence: 99%

Snake venom hyaluronidase: a therapeutic target

Kemparaju

Girish

2005

Cell Biochem. Funct.

153

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The diffusion of toxins from the site of a bite into the circulation is essential for successful envenomation. Degradation of hyaluronic acid in the extracellular matrix (ECM) by venom hyaluronidase is a key factor in this diffusion. Hyaluronidase not only increases the potency of other toxins but also damages the local tissue. In spite of its important role, little attention has been paid to this enzyme. Hyaluronidase exists in various isoforms and generates a wide range of hyaluronic acid degradation products. This suggests that beyond its role as a spreading factor venom hyaluronidase deserves to be explored as a possible therapeutic target for inhibiting the systemic distribution of venom and also for minimizing local tissue destruction at the site of the bite.

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“…SW480 and SW620 cells derived from the same patient provide good models for comparative proteome analysis of CRC metastasis-associated protein (Duranton et al 2003;Laurich et al 2004). However, the success of the approach is dependent on the phenotypic stability of the cells during serial passages in vitro and/or in vivo.…”

Section: Introductionmentioning

confidence: 99%