Hyaluronan nanoplatelets exert an intrinsic anti-inflammatory activity in a rat model of bladder painful syndrome/interstitial cystitis

Neonatal Cystitis Makes Adult Female Rat Urinary Bladders More Sensitive to Low Concentration Microbial Antigens

“…In addition, a robust response often requires pretreatment with agents such as intravesical protamine, presumably stripping the GAG layer of the urothelium of the bladder. [42][43][44][45][46][47][48][49][50][51][52] Our own previously reported experience with intravesical LPS in rats failed to observe a statistically significant effect of pretreatment in control rats 17 https://doi.org/10.2147/RRU.S444167 DovePress but was robustly present in NBI rats. The responses to intravesical Zymosan in the NCT rats were consistent with those in normal control rats in a previous study.…”

Anti‐Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials

“…Using well-established nanoformulation approaches, TPCD can also be facilely produced into NPs with various sizes (Figure 3d). Correspondingly, NPs based on TPCD efficaciously protected cells from ROS-induced inflammatory responses and β-CD Methyl β-CD None Reduce accumulation of ROS in yeast [91] β-CD Ox-bCD NPs None ROS-responsive and anti-oxidation [96] β-CD OxbCD NPs None Inhibit oxidative/inflammatory responses in macrophages and peritonitis in mice [26] β-CD TPCD NPs None Eliminate a broad spectrum of ROS and antiinflammation in diverse diseases [24] β-CD HA-CsT@RH Rhein Achieve accurate drug release and inhibit inflammation [169] β-CD Naringenin/CD complexes Naringenin Enhance solubility/stability of the loaded antiinflammatory and ROS-scavenging drug [95] β-CD, γ-CD HP-β-CyD/HP-γ-CyD-based nanofibrous web Curcumin Enhanced antioxidant activity [94] γ-CD BCOF None Anti-oxidation and anti-inflammation [178] γ-CD LIG@OC-COF Ligustrazine Alleviate inflammation, oxidant stress, and lung damage [99] NPs capable of inhibiting inflammatory cell recruitment and activation α-CD P/bFGF@F127 αÀCD hydrogel bFGF and pinocembrin Inhibit infiltration of neutrophils [209] α-CD GAG nanoplatelets None Inhibit neutrophils infiltration and urothelial damage [210] β-CD HP-β-CD None Promote atherosclerosis regression via macrophage reprogramming [105] β-CD HP-β-CD None Attenuate the accumulation of lipid droplets, T lymphocytes, B lymphocytes, and plasma cells in stroke infarcts [107] β-CD pβCD None Hamper colonization of macrophages by interfering with lipid rafts [108] β-CD CSNP Simvastatin Reduce the plaque content of cholesterol and macrophages [106] β-CD β-CD-PDPA/DSPE-PEG miR-223 Regulate polarization of M1 to M2 macrophages [110] β-CD CDNPs based hydrogels Celastrol Target macrophages to modulate cell behaviors [116] β-CD LCD NP None Inhibit inflammatory responses, oxidative stress, and cell migration of neutrophils and macrophages [25,117] γ-CD LaCD NP None Regulate neutrophils, macrophages, airway epithelial cells, and smooth muscle cells [118,120] cell apoptosis in vitro as well as showed superior efficacies in three murine models of inflammatory diseases. Collectively, these findings provide fundamental insights into design and engineering of antioxidant and anti-inflammatory materials and/or NPs by rationally integrating various bioactive modules onto the CD scaffolds.…”

Mucoadhesive Thiolated Hyaluronic Acid/Pluronic F127 Nanogel Formation via Thiol–Maleimide Click Reaction for Intravesical Drug Delivery

“…HA has been widely used to develop various drug delivery systems for cancer therapy due to excellent biocompatibility, biodegradability, and biological properties . HA is a nonsulfated glycosaminoglycan (GAG) and has been used as an efficient GAG replenishment therapy to alleviate bladder painful syndrome/interstitial cystitis (BPS/IC), intravesical treatment of bacterial cystitis, and cystitis-induced hypercontractility . Huang et al have verified the efficacy and safety of intravesical instillation of HA combined with pirarubicin for NMIBC after transurethral resection .…”