2021
DOI: 10.29294/ijase.7.4.2021.1995-2005
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Hyaluronic Acid - 2-Deoxy-D-Glucose Conjugate Act as a Promising Targeted Drug Delivery Option for the Treatment of COVID-19

Abstract: In the present study, we propose Hyaluronic acid - 2-Deoxy-D-Glucose (HA-2DG) conjugate as a novel drug for the treatment of COVID-19. In silico molecular docking studies HA-2DG and 2-Deoxy-D-Glucose (2DG) against four different SARS-CoV-2 viral protein (Mpro, RdRp, PLpro and S protein) revealed that HA-2DG conjugate showed better binding affinity (-6.2, -7.2, -7.0 and 6.4 Kcal/mol) with all four screened SASR-CoV-2 viral targets than the antimetabolite drug 2DG alone (-4.8, -4.9, -4.6 and 4.7 Kcal/mol) respec… Show more

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“…antiviral drug against SARS-CoV-2. The influential role of 2-Deoxy-D-glucose was evident as a conjugate named Hyaluronic acid-2-Deoxy-D-Glucose against SARS-CoV-2 viral protein with better biodegradability and biocompatibility and minimal toxicity than 2-Deoxy-D-Glucose [5]. This analogue of glucose plays a crucial role in the glycolytic pathway and leads to the inhibition of glycolysis.…”
Section: Introductionmentioning
confidence: 99%
“…antiviral drug against SARS-CoV-2. The influential role of 2-Deoxy-D-glucose was evident as a conjugate named Hyaluronic acid-2-Deoxy-D-Glucose against SARS-CoV-2 viral protein with better biodegradability and biocompatibility and minimal toxicity than 2-Deoxy-D-Glucose [5]. This analogue of glucose plays a crucial role in the glycolytic pathway and leads to the inhibition of glycolysis.…”
Section: Introductionmentioning
confidence: 99%