Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications

Kogan, Grigorij; Šoltés, Ladislav; Stern, Robert; Gemeiner, Peter

doi:10.1007/s10529-006-9219-z

Cited by 875 publications

(619 citation statements)

References 36 publications

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“…VS by intraarticular injections of HA is used for reducing pain and improving joint mobility in patients with OA of the knee and other synovial joints [5,11] by restoring SF rheologic properties affected in OA. HA is a natural polysaccharide existing in the animal body [28,31,35] and especially in the joints where it plays an important role in lubrication, shock absorption, and viscoelastic behavior of the synovial fluid [8,17,22,39,58].…”

Section: Introductionmentioning

confidence: 99%

Rheologic Behavior of Osteoarthritic Synovial Fluid after Addition of Hyaluronic Acid: A Pilot Study

Mathieu

Conrozier

Vignon

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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Viscosupplementation is a symptomatic treatment of osteoarthritis (OA) intended to restore rheologic homeostasis of the synovial fluid by injecting hyaluronic acid intraarticularly. Despite the long history of this therapy, little is known about its mechanisms of action and differences between commercial preparations. We investigated the rheologic behavior of OA synovial fluid with time, when stored at 4°C, before and after the addition of two hyaluronic acid commercial preparations (linear and cross-linked). Thirteen OA synovial fluids were stored at 4°C and assayed using steric exclusion chromatography, which allows hyaluronic acid to be separated from the remaining pool of proteins and its molecular weight and concentration to be determined without any pretreatment and calibration. The synovial fluid rheology also was studied in vitro, before and after addition of two viscosupplements, over 6 weeks. The non-Newtonian behavior of synovial fluid throughout followup appears to be the result of loose interactions between proteins and hyaluronic acid. When mixed with the linear hyaluronic acid, synovial fluid becomes less non-Newtonian whereas the non-Newtonian behavior was reinforced when mixed with the cross-linked hyaluronic acid. The rheology was nearly unchanged for all synovial fluids over 6 weeks. Our preliminary trial shows it is possible to study synovial fluid, stored at 4°C, over a long time and suggests the enzymatic degradation of hyaluronic acid is negligible under these experimental conditions.

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Section: Introductionmentioning

confidence: 99%

Rheologic Behavior of Osteoarthritic Synovial Fluid after Addition of Hyaluronic Acid: A Pilot Study

Mathieu

Conrozier

Vignon

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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“…infected by the Chlorovirus [49,83]-, yeasts such as Cryptococcus neoformans- [49] and molluscs [84]. However, it is not found in fungi, plants and insects [85].…”

Section: Ha Occurrence In Living Organism and Diffusion In Human Bodymentioning

confidence: 99%

Hyaluronic Acid in the 3<sup>rd</sup> Millennium

Fallacara¹,

Baldini²,

Manfredini³

et al. 2018

Preprint

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Since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid is almost ubiquitary in humans and in other vertebrates. HA is involved in many key processes -including cell signaling, wound reparation, tissue regeneration, morphogenesis, matrix organization and pathobiology-, and has unique physico-chemical properties -such as biocompatibility, biodegradability, mucoadhesivity, hygroscopicity and viscoelasticity. For these reasons, exogenous HA has been investigated as drug delivery system and treatment in cancer, ophthalmology, arthrology, pneumology, rhinology, urology, aesthetic medicine and cosmetic. To improve and customize its properties and applications, HA can be subjected to chemical modifications: conjugation and crosslinking. The present review gives an overview regarding HA, describing its history, physico-chemical, structural and hydrodynamic properties, and biology -occurrence, biosynthesis (by hyaluronan synthases), degradation (by hyaluronidases and oxidative stress), roles, mechanisms of action and receptors. Furthermore, both conventional and recently emerging methods developed for the industrial production of HA and its chemical derivatization are presented. Finally, the medical, pharmaceutical and cosmetic applications of HA and its derivatives are reviewed, reporting examples of HA-based products which currently are on the market or are undergoing further investigations.

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“…Acosta et al, 2011;Ahmed et al, 2008;Colombini et al, 2014;Diederichs et al, 2012;Eyrich et al, 2007;Hegewald et al, 2010;Ho et al, 2010;Likhitpanichkul et al, 2014;Ma et al, 2012;Park et al, 2011b;Pirvu et al, 2015;Schek et al, 2011;Stern et al, 2000;Stern et al, 2004;Sung et al, 1999;Wang et al, 2005 Hyaluronan Chicken comb, fermentation Drug delivery, synovial fluid supplementation In vivo increase in disc height combined with MSCs. Chen et al, 2013;Chung et al, 2009;Collin et al, 2011;Erickson et al, 2009;Kenne et al, 2013;Kogan et al, 2007;Su et al, 2010 Collagen & gelatin …”

Section: Culture Mediamentioning

confidence: 99%

“…Hyaluronan derivatives are clinically applied for drug delivery and surgical procedures (Kogan et al, 2007). Biodegradation of HA occurs by the action of hyaluronidases and degradation rate can be adjusted by the incorporation of methacrylate groups also used for photocrosslinking (Kim et al, 2011).…”

Section: Hyaluronanmentioning

confidence: 99%

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

Schutgens¹,

Tryfonidou²,

Smit³

et al. 2015

eCM

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Intervertebral disc (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become the number one cause of loss of quality-adjusted life years. In search of alternatives to the current less than optimal and usually highly invasive treatments, regenerative strategies are being devised, none of which has reached clinical practice as yet. Strategies include the use of stem cells, gene therapy, growth factors and biomaterial carriers. Biomaterial carriers are an important component in musculoskeletal regenerative medicine techniques. Several biomaterials, both from natural and synthetic origin, have been used for regeneration of the IVD in vitro and in vivo. Aspects such as ease of use, mechanical properties, regenerative capacity, and their applicability as carriers for regenerative and anti-degenerative factors determine their suitability for IVD regeneration. The current review provides an overview of the biomaterials used with respect to these properties, including their drawbacks. In addition, as biomaterial application until now appears to have been based on a mix of mere availability and intuition, a more rational design is proposed for future use of biomaterials for IVD regeneration. Ideally, high-throughput screening is used to identify optimally effective materials, or alternatively medium content comparative studies should be carried out to determine an appropriate reference material for future studies on novel materials.

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Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications

Cited by 875 publications

References 36 publications

Rheologic Behavior of Osteoarthritic Synovial Fluid after Addition of Hyaluronic Acid: A Pilot Study

Rheologic Behavior of Osteoarthritic Synovial Fluid after Addition of Hyaluronic Acid: A Pilot Study

Hyaluronic Acid in the 3<sup>rd</sup> Millennium

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies

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