Hyaluronic Acid Accelerates VEGF and PDGF Release from Advance Platelet Rich Fibrin in Diabetic Foot Ulcer

Kartika, Ronald Winardi; Alwi, Idrus; Suyatna, Franciscus D.; Sandra, Ferry; Yunir, Em; Waspadji, Sarwono; Immanuel, Suzzana; Silalahi, Todung; Sungkar, Saleha; Rachmat, Jusuf; Bardosono, Saptawati; Reksodiputro, Mirta Hediyati

doi:10.18585/inabj.v13i3.1523

Cited by 1 publication

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“…It contributes to wound healing by providing supportive structures for the extracellular matrix which acts as a base structure for the healing tissue 10 . Furthermore, HA improves wound healing by increasing the level of specific growth factors in the wound milieu, 11 which decreases time to heal and reduces scars 12,13 . A systematic review and meta‐analysis from 2012 finds that various end points such as wound healing, time to heal, wound area or granulation are improved in eight of 10 studies by the application of HA 14 .…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid treatment versus standard of care in chronic wounds in a German setting: Cost‐effectiveness analysis

Blunck

Schöffski

2022

Health Science Reports

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Background and Aims Chronic wounds are a major burden for worldwide health care systems. In the management of chronic wounds several strategies with innovative and active agents emerged in the past few years, such as hyaluronic acid containing wound dressings. Evidence comparing the cost‐effectiveness of hyaluronan and standard of care dressings (hydrofiber with silver) is still missing. The aim of the study is thus, to assess the cost‐effectiveness of hyaluronan versus standard of care dressings (hydrofiber with silver) in chronic wounds from a German statutory health insurance perspective. Methods A decision tree was modeled to quantify the cost and healing rate at 12 weeks for the hyaluronan and silver dressings strategies. Input parameters were collected literature‐based, accounting for healing rates, dressing prices and prices for dressing changes and associated home care. Parameter uncertainty was accounted for by one‐way and probabilistic sensitivity analysis. Results Hyaluronic acid showed a better healing rate (60.68%) and noticeable lower cost (749.80 Euro) compared to standard of care (silver containing) dressings (59.62%; 883.05 Euro), resulting in an Incremental Cost Effectiveness Ratio of −12,570.57. The hyaluronan approach is hence a dominant strategy in chronic wound management. Sensitivity analysis confirmed these results, giving a range of 60%– 70% of cost‐effective scenarios. Conclusions Hyaluronic acid dressings showed to be a clinical more effective strategy at significantly lower cost in chronic wounds compared to standard of care (hydrofiber with silver).

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