Hyaluronic Acid act as a Non - Invasive Marker for Diagnosis of Liver Fibrosis in the Patients of Chronic Hepatitis C

Abstract

350 samples, 100 normal samples were recruited as control group and 250 diagnosed cases of chronic hepatitis C patients were recruited as case study group. Serum Hyaluronic acid was significantly (P<0.001) elevated in patients (195.77 ±6.67) compared to controls (110.2 ±0.79) irrespective of gender involvement. CONCLUSION: The current findings showed significant involvement of HA in early prognosis of liver fibrosis and cirrhosis among chronic HCV patients that would probably useful to reduce repetitive liver biopsy.

Association of Serum Hyaluronic Acid and Laminin with Polymerase Chain Reaction Findings in Hepatitis C Patients

“…A study conducted by Akram et al concluded in contrast to the control group, HA levels were found to be two times higher among people infected with hepatitis C. 16 Murawaki et al have reported statistically significant variations in HA levels in chronic hepatitis C patients at different stages of hepatic fibrosis. 17 Tao et al also reported the higher levels of serum HA and LN among cases and controls of cirrhotic patients as the stages of fibrosis advances.…”