Hyaluronic acid and albumin based nanoparticles for drug delivery

Lei, Can; Liu, Xiu-Ran; Chen, Quanbing; Li, You; Zhou, Jiali; Zhou, Ling-Yue; Zou, Tao

doi:10.1016/j.jconrel.2021.01.033

Cited by 181 publications

(83 citation statements)

References 204 publications

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“…Since albumin has an isoelectric point (pI) of 4.25, under physiological pH conditions it exists as an anion with a very dense negative charge. In addition, carboxyl and amino groups present on the albumin surface, allow binding to albumin through covalent or non-covalent bonds [45,46]. On the other hand, albumin negative charge densification further enhances albumin stability and ensures its long-term circulation in the blood due to intense repulsion from negatively charged serum proteins [45,[47][48][49].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, carboxyl and amino groups present on the albumin surface, allow binding to albumin through covalent or non-covalent bonds [45,46]. On the other hand, albumin negative charge densification further enhances albumin stability and ensures its long-term circulation in the blood due to intense repulsion from negatively charged serum proteins [45,[47][48][49]. Hyaluronic acid has a moisturising and repairing function as a component of the skin matrix.…”

Section: Discussionmentioning

confidence: 99%

“…Five replicates were performed for each hydrogel formulation. Samples of 3 mL were taken after: 5, 10, 15,20,30,45,60,90,120,150,180,210,240,270, 300, 330 and 360 min. The volume of samples after each sampling for measurements was supplemented to 50 mL.…”

Section: Corticotropin Release Studymentioning

confidence: 99%

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Modelling and Control of Corticotropin Permeation from Hydrogels across a Natural Membrane in the Presence of Albumin

2021

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(1) Background: Skin is a difficult barrier to overcome, especially for molecules with masses greater than 500 Da. It has been suggested that albumin may contribute to more effective penetration of many therapeutic substances. In this study, an attempt was made to use albumin in semi-solid formulations to increase the skin penetration of another peptide—corticotropin (ACTH). (2) Methods: Hydrogels were prepared at two concentrations: 15 mg/g and 20 mg/g corticotropin, then albumin was added to them in different stoichiometric ratios. The degree of ACTH release from hydrogels, both with and without albumin addition, was investigated. For selected hydrogels the process of corticotropin permeation through a model membrane, i.e., pig skin, was examined. (3) Results: The study of corticotropin release showed that the addition of albumin, depending on its amount, may delay or increase the release process. Similarly, a study of ACTH permeation through porcine skin showed that albumin can delay or increase and accelerate ACTH permeation. (4) Conclusions: Hydrogel, applicated on the skin surface, may prove to be a beneficial and convenient solution for patients. It is an innovative way of application ACTH that bypasses the gastrointestinal tract and may result in increased availability of the peptide and its efficacy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Modelling and Control of Corticotropin Permeation from Hydrogels across a Natural Membrane in the Presence of Albumin

2021

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“…Thirdly, the immunogenicity and biological safety of the natural polysaccharide‐based conjugates and drug delivery systems need to be thoroughly evaluated. [ 120,121 ] Natural glycans such as HA have already been extensively used as injectable skin fillers in the cosmetic industry, which is considered relatively safe as an implant material. [ 122 ] Both HA and CS have already been formulated as an intraarticular injection to alleviate joint pains in knees affected by arthritis.…”

Section: Discussionmentioning

confidence: 99%

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Niu

Xue

2021

Macromolecular Bioscience

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Inflammation is closely related to a variety of fatal or chronic diseases. Hence, targeting inflammation provides an alternative approach to improve the therapeutic outcome of diseases such as solid tumors, neurological diseases, and metabolic diseases. Polysaccharides are natural components with immune regulation, anti‐virus, anti‐cancer, anti‐inflammation, and anti‐oxidation activities. Herein, this review highlights recent progress in the polysaccharide‐based drug delivery systems for achieving inflammation targeting and its related disease treatment. Moreover, the chemical modification and the construction of polysaccharide materials for drug delivery are discussed in detail.

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“…NPs made of HA with the highest Mws (820 and 710 kD) and similar dimensions (mean size around 210-250 nm) showed comparable Myo release profiles. The slowest Myo release profile was detected from NPs made of HA with the lowest Mw (mean diameter around 250 nm), This behaviour can be ascribed to the higher flexibility of HA chains able to more tightly interact with CS to form NPs with compact structure [68]. The order of drug release kinetics was determined by plotting the cumulative concentration of drug against time and square root of time.…”

Section: Myo Loading In Ha Npsmentioning

confidence: 99%

Hyaluronic Acid-Based Nanoparticles for Protein Delivery: Systematic Examination of Microfluidic Production Conditions

et al. 2021

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Hyaluronic acid-based nanoparticles (HA NPs) can be used to deliver a protein cargo to cells overexpressing HA receptors such as CD44 since they combine the low toxicity of the carrier and the retention of the protein integrity with the receptor-mediated internalization. HA properties play a crucial but sometimes unclear role in managing the formation and stability of the meshwork, cell interactions, and ultimately the protein entrapment efficacy. Nowadays, microfluidic is an innovative technology that allows to overcome limits linked to the NPs production, guaranteeing reproducibility and control of individual batches. Taking advantage of this technique, in this research work, the role of HA weight average molecular weight (Mw) in NPs formation inside a microfluidic device has been specifically faced. Based on the relationship between polymer Mw and solution viscosity, a methodological approach has been proposed to ensure critical quality attributes (size of 200 nm, PDI ≤ 0.3) to NPs made by HA with different Mw (280, 540, 710 and 820 kDa). The feasibility of the protein encapsulation was demonstrated by using Myoglobin, as a model neutral protein, with an encapsulation efficiency always higher than 50%. Lastly, all NPs samples were successfully internalized by CD44-expressing cells.

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Hyaluronic acid and albumin based nanoparticles for drug delivery

Cited by 181 publications

References 204 publications

Modelling and Control of Corticotropin Permeation from Hydrogels across a Natural Membrane in the Presence of Albumin

Modelling and Control of Corticotropin Permeation from Hydrogels across a Natural Membrane in the Presence of Albumin

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Hyaluronic Acid-Based Nanoparticles for Protein Delivery: Systematic Examination of Microfluidic Production Conditions

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