Hyaluronic acid and tendon lesions

Kaux, J F; Samson, Antoine; Crielaard, J M

doi:10.32098/mltj.04.2015.02

Cited by 43 publications

(46 citation statements)

References 40 publications

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“…), others remain chronic. It is for this reason that a lot of research has been carried out to develop or adapt treatments for such rebel conditions, among which PRP and HA (13,28). Some clinical studies have previously evaluated the effect of PRP in the treatment of proximal patellar tendinopathies (6,23,24,29).…”

Section: Discussionmentioning

confidence: 99%

“…Even if this treatment remains controversial in the literature, recent systematic reviews have concluded that PRP could be recommend (low evidences) as a treatment in such indications (8)(9)(10)(11)(12). The use of HA in the treatment of tendinopathies is even more recent in clinical practice, even if pre-clinical studies in the healing process of tendons have been reported in the past 20 years (13,14,30). However, it seems that HA injections have been effective in small groups of patients with tendinopathies (13).…”

Section: Discussionmentioning

confidence: 99%

“…The use of HA in the treatment of tendinopathies is even more recent in clinical practice, even if pre-clinical studies in the healing process of tendons have been reported in the past 20 years (13,14,30). However, it seems that HA injections have been effective in small groups of patients with tendinopathies (13).…”

Section: Discussionmentioning

confidence: 99%

“…Even if there exists a lack of general agreement concerning its preparation and use, and that recent systematic reviews are controversial, some of these have concluded that PRP could be appropriate as a treatment in such indications (8)(9)(10)(11)(12). Recently, the anti-inflammatory and viscoelastic properties of hyaluronic acid (HA) on liquid connective tissue have been suggested for the treatment of tendinopathies (13). Some fundamental studies show encouraging results concerning HA's J.-F. Kaux, S. Bornheim, n. DarDenne, r. DeroiSy, a. SamSon, m. roBerJot, J.-L. CroiSier ability to promote tendon gliding and reduce adhesion as well as to improve the tendon's architectural organisation (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

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Comparison between platelet-rich plasma injections and hyaluronic acid injections in the treatment of patellar tendinopathies: a randomized trial

Kaux

Bornheim

Dardenne

et al. 2019

Muscle Ligaments and Tendons J

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Background. As patellar tendinopathies are frequently chronic there has been plenty of research carried out to develop effective treatments, among which platelet-rich plasma (PRP) and hyaluronic acid (HA). Hypothesis. Therefore we aimed to compare the effect after three months following injections of PRP compared with HA injections on patients with a proximal patellar tendinopathy. Methods. 33 sportsmen with chronic proximal patellar tendinopathies were included and randomised into 2 groups and treated respectively with PRP (obtained using an apheresis machine) or HA injections. To assess the evolution of the pathology, algo-functional tests (VISA-P and IKDC) and isokinetic tests were carried out pre-injection, after 6 weeks and after 3 months post-injections. Results. The results of VAS, algometric scores, IKDC scores and VISA-P showed a considerable improvement in the two groups over time (p<0.01), except for the US findings. Isokinetic tests showed significant modifications for the quadriceps in C60 (p=0.01) for the pathological limb only at the end of the follow-up period. VAS associated with isokinetic tests decreased significantly for all contraction modes after three months in the HA group (p<0.05). Correlations showed that there was a significant negative association between VAS and strength in C60, C240 and E30 (p<0.01) only for the PRP group. Conclusion. Both PRP and HA can alleviate the symptoms of proximal patellar tendinopathy in the medium term. However, only PRP leads to a decrease in pain associated with an increase in the strength of the quadriceps.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison between platelet-rich plasma injections and hyaluronic acid injections in the treatment of patellar tendinopathies: a randomized trial

Kaux

Bornheim

Dardenne

et al. 2019

Muscle Ligaments and Tendons J

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“…Hyaluronic acid is a linear, anionic, nonsulfated glycosaminoglycan with unique characteristics. HA molecules are polymers of disaccharides (up to 25000 disaccharide repeat units in length) composed of D-glucuronic acid and N-acetyl-D-glucosamine, linked via alternating β(1→4) and β(1→3) glycosidic bonds (7).…”

Section: Introductionmentioning

confidence: 99%

Alpha-2-macroglobulin and hyaluronic acid as fibromarkers in patients with chronic hepatitis C

Pitekova¹,

Kupčová²,

Uhlíková³

et al. 2017

BLL

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Influence of steel implant surface microtopography on soft and hard tissue integration

et al. 2017

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After implantation of an internal fracture fixation device, blood contacts the surface, followed by protein adsorption, resulting in either soft-tissue adhesion or matrix adhesion and mineralization. Without protein adsorption and cell adhesion under the presence of micro-motion, fibrous capsule formation can occur, often surrounding a liquid filled void at the implant-tissue interface. Clinically, fibrous capsule formation is more prevalent with electropolished stainless steel (EPSS) plates than with current commercially pure titanium (cpTi) plates. We hypothesize that this is due to lack of micro-discontinuities on the standard EPSS plates. To test our hypothesis, four EPSS experimental surfaces with varying microtopographies were produced and characterized for morphology using the scanning electron microscope, quantitative roughness analysis using laser profilometry and chemical analysis using X-ray photoelectron spectroscopy. Clinically used EPSS (smooth) and cpTi (microrough) were included as controls. Six plates of each type were randomly implanted, one on both the left and right intact tibia of 18 white New Zealand rabbits for 12 weeks, to allow for a surface interface study. The results demonstrate that the micro-discontinuities on the upper surface of internal steel fixation plates reduced the presence of liquid filled voids within soft-tissue capsules. The micro-discontinuities on the plate under-surface increased bony integration without the presence of fibrous tissue interface. These results support the hypothesis that the fibrous capsule and the liquid filled void formation occurs mainly due to lack of micro-discontinuities on the polished smooth steel plates and that bony integration is increased to surfaces with higher amounts of micro-discontinuities. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 705-715, 2018.

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Hyaluronic acid and tendon lesions

Abstract: Hyaluronic acid and tendon lesions by limited but encouraging short-term clinical results on pain and function. However, controlled randomised studies are still needed.

Cited by 43 publications

References 40 publications

Comparison between platelet-rich plasma injections and hyaluronic acid injections in the treatment of patellar tendinopathies: a randomized trial

Comparison between platelet-rich plasma injections and hyaluronic acid injections in the treatment of patellar tendinopathies: a randomized trial

Alpha-2-macroglobulin and hyaluronic acid as fibromarkers in patients with chronic hepatitis C

Influence of steel implant surface microtopography on soft and hard tissue integration

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