Hyaluronic acid as a biomarker of fibrosis in chronic liver diseases of different etiologies

Orășan, Olga Hilda; Ciulei, George; Cozma, Angela; Sava, Madalina; Dumitraşcu, Dan L.

doi:10.15386/cjmed-554

Cited by 37 publications

(32 citation statements)

References 72 publications

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“…Hence, noninvasive and easily accessible methods of predicting stages of hepatic fibrosis have been developed in human medicine. Consequently, in human patients with hepatic fibrosis, hyaluronic acid (HA), which is an essential component of the extracellular matrix, is widely used as a direct marker for the assessment of hepatic fibrosis . Similarly, in veterinary medicine, several studies have reported that the blood HA concentration is increased in dogs with hepatic disease .…”

Section: Introductionmentioning

confidence: 99%

Usefulness of noninvasive shear wave elastography for the assessment of hepatic fibrosis in dogs with hepatic disease

Tamura

Ohta

Shimbo

et al. 2019

Veterinary Internal Medicne

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Background Two‐dimensional shear wave elastography (2D‐SWE) can noninvasively evaluate hepatic elastic modulus as shear wave velocity (SWV). Additionally, it may predict the presence of clinical relevant hepatic fibrosis (≥F2) in dogs with hepatic disease. Objectives To investigate whether SWV measured by 2D‐SWE can differentiate between dogs with (≥F2) and without (F0‐1) clinically relevant hepatic fibrosis. Animals Twenty‐eight client‐owned dogs with hepatic disease and 8 normal healthy Beagle dogs were enrolled. Methods In this cross‐sectional prospective study, SWVs were measured using 2D‐SWE in all dogs. Hepatic fibrosis stages and necroinflammatory activity grades were histopathologically evaluated using a histological scoring scheme that was adapted from the Ishak schema used in human medicine. Results Median SWVs were significantly higher in dogs with clinically relevant hepatic fibrosis (2.04 m/s; range, 1.81‐2.26 m/s) than in healthy dogs (1.51 m/s; range, 1.44‐1.66 m/s; P = .007), and dogs without clinically relevant hepatic fibrosis (1.56 m/s; range, 1.37‐1.67 m/s; P < .001). However, no significant difference was found in the SWVs between dogs without clinically relevant hepatic fibrosis and healthy dogs (P = .99). Furthermore, median SWVs were not significantly different among dogs with necroinflammatory activity, those without necroinflammatory activity, and healthy dogs (Kruskal‐Wallis test, P = .12). Conclusions and Clinical Importance The 2D‐SWE may be useful for predicting the presence of hepatic fibrosis in dogs with hepatic disease.

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Section: Introductionmentioning

confidence: 99%

Usefulness of noninvasive shear wave elastography for the assessment of hepatic fibrosis in dogs with hepatic disease

Tamura

Ohta

Shimbo

et al. 2019

Veterinary Internal Medicne

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“…This is not surprising since haptoglobin in wellknown marker of liver fibrosis and is incorporated in Fibrotest formula [37]. Serum concentration of hyaluronic acid seems to be biomarker of fibrosis in chronic liver diseases of different etiologies [38] such as non-alcoholic fatty liver disease [39], alcoholic fatty liver disease [40], and viral hepatitis [41].…”

Section: Discussionmentioning

confidence: 99%

The immunoreactivity of TGF-b1 in non-alcoholic fatty liver disease

Kempiński¹,

Neubauer²,

Poniewierka³

et al. 2019

Folia Histochem Cytobiol.

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Introduction. Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease which becomes a rapidly growing health problem in the Western countries. The development of the disease is most often connected to obesity. NAFLD is also considered as the hepatic manifestation of metabolic syndrome. Transforming growth factor b1 (TGF-b1) plays an important role in the pathogenesis of liver fibrosis, being involved in activation of hepatic stellate cells, stimulation of collagen gene transcription, and suppression of matrix metalloproteinase expression. The objective of the study was to evaluate by immunohistochemistry the expression of TGF-b1 in the liver tissue of NAFLD patients and correlate it with anthropometric, biochemical and routine histological parameters. Material and methods. The study group consisted of 48 patients with diagnosed NAFLD. Liver steatosis, NAFLD Activity Score (NAS) and METAVIR score of fibrosis were evaluated in liver biopsies. The immunoreactivity of TGF-b1 was evaluated semi-quantitatively separately in portal, septal, lobular hepatocytic and lobular sinusoidal liver compartments. The results were analyzed in regard to patients' clinical and biochemical parameters. Results. Neither steatosis nor NAS correlated with TGF-b1 expression in any liver compartment, whereas METAVIR score of fibrosis was associated with increased immunoreactivity of TGF-b1 in most of the studied liver compartments. TGF-b1 immunoreactivity showed positive correlation with patients' age and its expression in septal compartment disclosed positive correlation with body mass index, and waist and hip circumference. Hyaluronic acid serum level was positively and iron concentration was negatively associated with TGF-b1 expression in the selected consecutive liver compartments. Conclusions. The immunohistochemical expression of TGF-b1 may be complementary to routine methods of liver fibrosis evaluation.

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“…Among cirrhotic liver subjects, high levels of HA in ALD suggests that the degree of necroinflammation will be varied in different etiologies and it is high in alcohol induced liver injury. HA is produced from activated HSCs after transdifferentiate into myofibroblasts due to inflammation mediated by complex cytokine network [21]. Elevated levels of HA in cirrhotic liver subjects is due to imbalance between synthesis from fibrogenesis and decrease in fibrolysis during the disease progression, dysfunction of sinusoidal endothelial cells leads to reduction in degradation of HA resulting in elevated levels in circulation [8,22].…”

Section: Discussionmentioning

confidence: 99%

Correlative Study of Hyaluronic Acid and YKL-40 with Conventional Markers for Cirrhosis of Liver

Kn¹

2018

GHR

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Hyaluronic acid as a biomarker of fibrosis in chronic liver diseases of different etiologies

Cited by 37 publications

References 72 publications

Usefulness of noninvasive shear wave elastography for the assessment of hepatic fibrosis in dogs with hepatic disease

Usefulness of noninvasive shear wave elastography for the assessment of hepatic fibrosis in dogs with hepatic disease

The immunoreactivity of TGF-b1 in non-alcoholic fatty liver disease

Correlative Study of Hyaluronic Acid and YKL-40 with Conventional Markers for Cirrhosis of Liver

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