Hyaluronic acid as prognostic marker in resectable colorectal cancer

Abstract

There is a wide variability in cytosolic HA levels in colorectal carcinomas, which seems to be related to the biological heterogeneity of these tumours. In addition, high tumour cytosolic HA levels were associated with an unfavourable outcome in patients with resectable colorectal cancer. HA may provide additional information to that given by other biochemical markers currently used in colorectal cancer.

Expression and clinical significance of CD44V5 and CD44V6 in resectable colorectal cancer

“…This is in accordance with previous reports (Llaneza et al 2000), and seems to indicate a possible role of CD44v6 in the progression of colorectal carcinomas. Likewise, it has been reported that CD44v6 expression progressively increases following the normal mucosaadenoma-carcinoma sequence Kim et al 1994;Neumayer et al 1999).…”

“…Likewise, it has been reported that CD44v6 expression progressively increases following the normal mucosaadenoma-carcinoma sequence Kim et al 1994;Neumayer et al 1999). However, in the present study, membranous CD44v5 levels did not change significantly between tumors and non-neoplastic mucosal samples, which is in accordance with one of our preliminary reports using also immunoenzymatic assay (Llaneza et al 2000). On the other hand, our results show that CD44v5 levels were significantly lower in tumors from proximal colon, for which we do not have a reasonable explanation at the present time.…”

The glycocalyx and its significance in human medicine

“…HS has long been known to be essential for tumour growth [72,73], and more recent data also show that HS is required for tumour angiogenesis [74]. Increased HA expression is a consistent feature of a wide range of human cancers and has been linked to aggressive tumour progression [75,76].…”

Analysis of the expression of hyaluronan in intraductal and invasive carcinomas of the breast

“…As a component of extracellular matrices, hyaluronan inXuences tissue morphogenesis and has several physiological functions, such as water homeostasis, regulation of capillary growth, cell recognition, and cell migration (Fraser et al 1997). In addition, elevated concentrations of hyaluronan have also been found in several human tumors (Arai et al 1979;Hopwood and Dorfman 1978;Llaneza et al 2000;Setala et al 1999;Sowa et al 1989;Vizoso et al 2004;Wang et al 1996), including breast carcinomas (Auvinen et al 2000;Bertrand et al 1992;de la Torre et al 1993;Ponting et al 1992;Takeuchi et al 1976). Likewise, experimental studies have shown that increased concentrations of hyaluronan stimulate cell motility (Goebeler et al 1996), cell adhesion (Catterall et al 1999), neovascularization (Koyama et al 2007;Rooney et al 1995) and development of metastases in neoplastic tissues (Zhang et al 1995).…”