Hyaluronic Acid‐Based 3D Bioprinted Hydrogel Structure for Directed Axonal Guidance and Modeling Innervation In Vitro
Laura Honkamäki,
Oskari Kulta,
Paula Puistola
et al.
Abstract:Neurons form predefined connections and innervate target tissues through elongating axons, which are crucial for the development, maturation, and function of these tissues. However, innervation is often overlooked in tissue engineering (TE) applications. Here, multimaterial 3D bioprinting is used to develop a novel 3D axonal guidance structure in vitro. The approach uses the stiffness difference of acellular hyaluronic acid‐based bioink printed as two alternating, parallel‐aligned filaments. The structure has … Show more
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