Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical Study

Suchánek, J; Ivančaková, Romana; Mottl, Radovan; Browne, Klára Zoe; Pilneyová, Kristýna Charlotte; Pilbauerova, Nela; Schmidt, Jan; Kleplová, Tereza Suchánková

doi:10.3390/ijerph16193698

Cited by 23 publications

(28 citation statements)

References 28 publications

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“…Type I collagen was used as a migration influence coating, adhesion, proliferation and differentiation of cells on titanium implants improving early osteogenesis but without formation of bone far from the surface of the same. The positive influence coating of titanium implants through the use of biomolecules was also confirmed in small pig’s models; in the experimental study, the authors found a greater correlation between implant and bone density increase [ 64 , 65 , 66 ].…”

Section: Studies On Surface Modifications Of Dental Implants Using Hamentioning

confidence: 85%

Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data

Cervino

Meto

Fiorillo

et al. 2021

IJERPH

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Recently, interest has grown by focusing on the evaluation of a molecule already produced in the human body such as hyaluronic acid (HA), as an application to the surface of the titanium implant. Its osteo-conductive characteristics and positive interaction with the progenitor cells responsible for bone formation, consequently, make it responsible for secondary stability. The aim of this work was to analyze the various surface treatments in titanium implants, demonstrating that the topography and surface chemistry of biomaterials can correlate with the host response; also focusing on the addition of HA to the implant surface and assessing the biological implications during early stages of recovery. Used as a coating, HA acts on the migration, adhesion, proliferation and differentiation of cell precursors on titanium implants by improving the connection between implant and bone. Furthermore, the improvement of the bioactivity of the implant surfaces through HA could therefore facilitate the positioning of the dental prosthesis precisely in the early loading phase, thus satisfying the patients’ requests. It is important to note that all the findings should be supported by further experimental studies in animals as well as humans to evaluate and confirm the use of HA in any field of dentistry.

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Section: Studies On Surface Modifications Of Dental Implants Using Hamentioning

confidence: 85%

Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data

Cervino

Meto

Fiorillo

et al. 2021

IJERPH

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“…KH je glykosaminoglykan, který má pro své protizánětlivé, hydratační, regenerační, osteokonduktivní a biokompatibilní vlastnosti potenciál využití i ve stomatologii [40,41]. Díky variabilním možnostem jeho technologického zpracování je k dispozici ve formě spongiózní, tuhé, gelu či prášku, a dovoluje tak zvolit ideální provedení podle místa aplikace [42].…”

Section: Diskuse a Závěrunclassified

“…KH je tak široce využitelným materiálem pro celou řadu indikací. Na našem pracovišti jsme úspěšně otestovali aplikaci spongiózního materiálu vzniklého lyofilizací roztoku KH s oktenidin dihydrochloridem pro léčbu alveolární ostitis [40]. Při autologní transplantaci fibroblastů kolonizujících nosič z KH byl tento materiál použit jako štěp pro krytí gingiválních recesů [43,44].…”

Section: Diskuse a Závěrunclassified

Effect of Low, Medium and High Molecular Weight Hyaluronic Acid on Human Dental Pulp Stem Cells

Schmidt¹,

Pilbauerova²,

Soukup³

et al. 2020

Czech Dental Journal

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“…A new remedy based on hyaluronic acid (HA) and octenidine (OCT) is currently in Phase II of a clinical trial. It was developed for the treatment and prevention of AO [15].…”

Section: Introductionmentioning

confidence: 99%

Initial Observation of Factors Interfering with the Treatment of Alveolar Osteitis Using Hyaluronic Acid with Octenidine—A Series of Case Reports

et al. 2021

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Alveolar osteitis (AO) is a common complication following the extraction of the teeth, particularly the lower third molars. It starts within a few days after the extraction and manifests mainly as pain in the extraction site. Several strategies of treatment are available in order to relieve pain and heal the extraction wound. Recently, a novel medical device combining hyaluronic acid (HA) and octenidine (OCT) was introduced for the treatment of AO. This series of case reports aims to summarize the initial clinical experiences with this new device and to highlight factors possibly interfering with this treatment. The medical documentation of five patients with similar initial situations treated for AO with HA + OCT device was analyzed in detail. Smoking and previous treatment with Alveogyl (Septodont, Saint-Maur-des-Fossés, France) were identified as factors interfering with the AO treatment with the HA + OCT device. In three patients without these risk factors, the treatment led to recovery within two or three days. The patient pretreated with Alveogyl and the smoker required six and seven applications of the HA + OCT device, respectively. According to these initial observations, it seems smoking and previous treatment with Alveogyl prolong the treatment of AO using the HA + OCT device that, in turn, shows a rapid effect if these risk factors are not present.

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Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical Study

Cited by 23 publications

References 28 publications

Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data

Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data

Effect of Low, Medium and High Molecular Weight Hyaluronic Acid on Human Dental Pulp Stem Cells

Initial Observation of Factors Interfering with the Treatment of Alveolar Osteitis Using Hyaluronic Acid with Octenidine—A Series of Case Reports

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