Hyaluronic acid—Based wound dressings: A review

Graça, Mariana F.P.; Miguel, Sónia P.; Cabral, Cátia S.D.; Correia, Ilídio J.

doi:10.1016/j.carbpol.2020.116364

Cited by 562 publications

(320 citation statements)

References 104 publications

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“…In addition, high molar mass (>10 6 g/mol) promotes anti-inflammatory and anti-angiogenic properties. Those properties made possible the successful introduction of this polysaccharide as a component of wound dressings, eye drops, and dietary supplements aimed at ensuring the proper functioning of articular cartilage [ 90 , 91 ].…”

Section: Amphiphilic Polymers As Nanoemulsion Stabilizers: From Symentioning

confidence: 99%

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

et al. 2020

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Recent developments in the fabrication of core-shell polymer nanocapsules, as well as their current and future applications, are reported here. Special attention is paid to the newly introduced surfactant-free fabrication method of aqueous dispersions of nanocapsules with hydrophobic liquid cores stabilized by amphiphilic copolymers. Various approaches to the efficient stabilization of such vehicles, tailoring their cores and shells for the fabrication of multifunctional, navigable nanocarriers and/or nanoreactors useful in various fields, are discussed. The emphasis is placed on biomedical applications of polymer nanocapsules, including the delivery of poorly soluble active compounds and contrast agents, as well as their use as theranostic platforms. Other methods of fabrication of polymer-based nanocapsules are briefly presented and compared in the context of their biomedical applications.

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Section: Amphiphilic Polymers As Nanoemulsion Stabilizers: From Symentioning

confidence: 99%

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

et al. 2020

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“…Being the principal component of the skin’s ECM, HA provides vital contribution to the wound healing process, by the production and release of pro-inflammatory cytokines and interleukins and by promoting the development of a fibrin clot. Additionally, it reduces the inflammatory cells infiltration with re-epithelization and granulation improvement, and it enhances the formation of blood vessels as well, that are of extreme relevance for skin regeneration’s melioration [ 101 ]. HA has been elected by scientists for the formulation of different electrospun mats as wound dressings, since it exhibits strong-water retention ability, biodegradability/biocompatibility, and advantageous actions on wound healing process.…”

Section: Electrospun Nanofibers In Wound Healingmentioning

confidence: 99%

“…The formation of nanofibers directly from pure HA aqueous solutions using an electro-blowing technique merging air flow, electrospinning, and heating has been mentioned [ 156 ]. Alternatively, for obtaining regular nanofibers, researchers have been associating HA either with bioactive agents or natural polymers (for the increase of HA’s biological performance) or with synthetic polymers (for the enhancement of its electrospinnability and mechanical properties) [ 101 , 157 ].…”

Section: Electrospun Nanofibers In Wound Healingmentioning

confidence: 99%

“…similar with CS, many studies demonstrated improved mechanical features of the HA-nanofibers obtained by means of electrospinning when HA it was blend with other biopolymers (collagen, starch, gelatin, chitosan) and synthetic polymers (PVA, PEO, PU, PLGA) [ 101 ];…”

Section: Figurementioning

confidence: 99%

“…due to the rapid and high in vitro/in vivo degradation of HA a periodic replacement of wound dressing is necessary, which can conduct to the formation of new lesions, enhanced risk of infection and suffering to the patient [ 101 ];…”

Section: Figurementioning

confidence: 99%

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An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.

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Microneedle Patches Integrated with Biomineralized Melanin Nanoparticles for Simultaneous Skin Tumor Photothermal Therapy and Wound Healing

Lei

Ding

et al. 2022

Adv Funct Materials

103

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Unhealed wound after malignant skin tumor resection, characterized by full‐thickness cutaneous defects, large open cavities, and incomplete tumor tissue resection are the leading cause for long recovery times, poor prognoses, and high recurrence among patients. Herein, a hyaluronic acid (HA)‐based microneedle (MN) functionalized with biomineralized melanin nanoparticles is fabricated to concurrently administer tumor photothermal therapy (PTT) and promote skin tissue regeneration. Natural melanin nanoparticles derived from cuttlefish ink (CINP) possessing antioxidative and photothermal functionalities are employed to scavenge ROS and implement PTT. Further, CINPs are encapsulated within an amorphous silica shell that served as a source of bioactive SiO44− to stimulate skin tissue regeneration. Due to the physical penetration characteristics of microneedles, the obtained CINP@SiO2‐HA MNs could exert photothermal eradication of the remaining subcutaneous tumor cells to avoid recurrence and inhibit Staphylococcus aureus infection in wound beds. Moreover, benefiting from ROS‐scavenging and SiO44− release, inflammatory environment can be well controlled and angiogenic gene expression can be up‐regulated for skin tissue regeneration. With requisite biofunctionality, convenient synthesis, and excellent biocompatibility, CINP@SiO2‐HA MNs accompanied with clinically feasible irradiation meet the multiple demands of tumor eradication and wound healing, holding great potential as a supplementary therapy following skin tumor resection.

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Hyaluronic acid—Based wound dressings: A review

Cited by 562 publications

References 104 publications

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

Microneedle Patches Integrated with Biomineralized Melanin Nanoparticles for Simultaneous Skin Tumor Photothermal Therapy and Wound Healing

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