Hyaluronic acid coated Pluronic F127/Pluronic P123 mixed micelle for targeted delivery of Paclitaxel and Curcumin

Anirudhan, T.S.; Varghese, Susan; Manjusha, V.

doi:10.1016/j.ijbiomac.2021.10.061

Cited by 34 publications

(12 citation statements)

References 51 publications

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“…HA can be prepared into suitable drug carriers by chemical modification while maintaining its biological function and biodegradability. 11 In recent years, HA-based self-assembled formulations have been investigated in transdermal delivery. For instance, HA–Cholesterol self-assembled nanoparticles and hydrotropic nicotinamide were developed to enhance the permeation of tacrolimus (FK506) in the treatment of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

Niu¹,

Yuan²,

Zhang³

et al. 2022

IJN

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Background The poor skin permeation and deposition of topical therapeutic drugs is a major issue in topical drug delivery, improving this issue is conducive to improving the topical therapeutic effect of drugs. Methods In this study, octadecylamine modified hyaluronic acid (OHA) copolymer was synthesized by amide reaction technique to prepare curcumin (CUR)-loaded micelles (CUR-M) for topical transdermal administration. CUR-M was successfully prepared by dialysis, and the formulation was evaluated for particle size, zeta potential, surface morphology, entrapment effciency (EE%), drug loading (DL), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and the in vitro drug release. Additionally, in vitro skin permeation and retention, in vivo topical analgesic and anti-inflammatory activity, and skin irritation were assessed. Results The mean drug loading (DL), drug entrapment efficiency (EE), hydrodynamic diameter and zeta potential of CUR-M were 8.26%, 90.86%, 165.64 nm and −26.85 mV, respectively. CUR-M was characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), it was found that there was an interaction between CUR and OHA, and CUR existed in CUR-M in an amorphous form. CUR-M exhibited sustained release in 48 h and good stability at 4 °C for 21days. CUR-M could significantly increase the skin penetration and retention of CUR and had better analgesic and anti-inflammatory activities in vivo when compared with CUR solution. Hematoxylin-eosin staining results revealed that the transdermal penetration mechanism of CUR-M might be related to the hydration of stratum corneum by HA. In addition, CUR-M showed no skin irritation to mouse skin. Conclusion CUR-M might be a promising and safe drug delivery system for the treatment of topical diseases.

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Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

Niu¹,

Yuan²,

Zhang³

et al. 2022

IJN

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“…Wei et al observed that P-gp inhibition by Pluronic copolymers is associated with the reduction of intracellular adenosine triphosphate (ATP) [31]. Encapsulation in Pluronic micelles has been reported to successfully improve the unfavourable physicochemical and biopharmaceutical characteristics of various drugs, in particular paclitaxel [32,33], lacidipine [34], isoliquiritigenin [35], niclosamide [36], sorafenib and verteporfin [37], curcumin [38,39], and cannabidiol [40].…”

Section: Introductionmentioning

confidence: 99%

Double-Loaded Doxorubicin/Resveratrol Polymeric Micelles Providing Low Toxicity on Cardiac Cells and Enhanced Cytotoxicity on Lymphoma Cells

et al. 2023

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The anthracycline antibiotic doxorubicin is a well-known antitumour agent, however its cardiotoxicity is a significant obstacle to therapy. The aim of the present study was to improve the safety of doxorubicin through its simultaneous encapsulation with a cardioprotective agent (resveratrol) in Pluronic micelles. The formation and double-loading of the micelles was performed via the film hydration method. Infrared spectroscopy proved the successful incorporation of both drugs. X-ray diffraction analyses revealed that resveratrol was loaded in the core, whereas doxorubicin was included in the shell. The double-loaded micelles were characterised by a small diameter (26 nm) and narrow size distribution, which is beneficial for enhanced permeability and retention effects. The in vitro dissolution tests showed that the release of doxorubicin depended on the pH of the medium and was faster than that of resveratrol. In vitro studies on cardioblasts showed the opportunity to reduce the cytotoxicity of doxorubicin through the presence of resveratrol in double-loaded micelles. Higher cardioprotection was observed when the cells were treated with the double-loaded micelles compared with referent solutions with equal concentrations of both drugs. In parallel, treatments of L5178 lymphoma cells with the double-loaded micelles revealed that the cytotoxic effect of doxorubicin was enhanced. Thus, the study demonstrated that the simultaneous delivery of doxorubicin and resveratrol via the micellar system enabled the cytotoxicity of doxorubicin in lymphoma cells and lowered its cardiotoxicity in cardiac cells.

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“…Numerous groups have attempted to develop nanodrug delivery systems, including micelles, polymeric nanoparticles, liposomes and solid lipid nanoparticles, in an effort to enhance the therapeutic efficacy of CU-PTX combinations and address the drug delivery issues. [23][24][25][26][27] Due to their exceptional biocompatibility, stability, safety, and modifiability, lipid nanoparticles have been researched as carriers for delivering insoluble medications like CU and/or PTX. [28][29][30] Particularly, Curcumin-human serum albumin nanoparticles decorated with programmed death ligand 1 (PDL1) binding peptide not only improve tumor-targeting drug delivery but also reestablish immune response by blocking PDL1/PD1 interaction.…”

Section: Introductionmentioning

confidence: 99%

Construction of Curcumin and Paclitaxel Co-Loaded Lipid Nano Platform and Evaluation of Its Anti-Hepatoma Activity in vitro and Pharmacokinetics in vivo

Wei¹,

Wei²,

Lin³

et al. 2023

IJN

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Purpose The present study aimed to construct a co-loading platform encapsulating curcumin and paclitaxel at ratios of 2:1–80:1 (w/w) designated “CU-PTX-LNP” and explored the synergistic effects of CU-PTX at different composite proportions on liver cancer cells using the combination index (CI) method. Methods The CU lipid nanoplatform (CU-LNP) formulation was optimized via single-factor and orthogonal experiments. Various concentrations of PTX were added to the optimal formulation of CU-LNP to generate CU-PTX-LNP and the nanoplatform characterized via differential scanning calorimetry (DSC), transmission electron microscope (TEM), X-ray diffraction (XRD), zeta potential, polydispersity index (PDI), and size analyses. The cumulative release, stability, and cytotoxicity of CU-PTX-LNP in LO2, HepG2, and SMMC-7221 cells were assessed in vitro, followed by safety investigation and pharmacokinetic studies in vivo. The anti-tumor activity of CU-PTX-LNP was also evaluated using nude mice. Results CU-PTX-LNP formulations containing CU:PTX at a range of proportions (2:1–80:1; w/w) appeared as uniformly dispersed nanosized spherical particles with high entrapment efficiency (EE> 90%), sustained release and long-lasting stability. Data from in vitro cytotoxicity assays showed a decrease in the IC 50 value of PTX of CU-PTX-LNP (by 5.47–332.7 times in HepG2 and 4.29–143.21 times in SMMC-7221 cells) compared to free PTX. In vivo, CU-PTX-LNP displayed excellent biosafety, significant anti-tumor benefits and enhanced pharmacokinetic behavior with longer mean residence time (MRT (0-t); CU: 4.31-fold, PTX: 4.61-fold) and half-life (t 1/2z; CU: 1.83-fold, PTX: 2.28-fold) relative to free drugs. Conclusion The newly designed CU-PTX-LNP platform may serve as a viable technological support system for the successful production of CU-PTX composite preparations.

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Hyaluronic acid coated Pluronic F127/Pluronic P123 mixed micelle for targeted delivery of Paclitaxel and Curcumin

Cited by 34 publications

References 51 publications

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

Hyaluronic Acid Micelles for Promoting the Skin Permeation and Deposition of Curcumin

Double-Loaded Doxorubicin/Resveratrol Polymeric Micelles Providing Low Toxicity on Cardiac Cells and Enhanced Cytotoxicity on Lymphoma Cells

Construction of Curcumin and Paclitaxel Co-Loaded Lipid Nano Platform and Evaluation of Its Anti-Hepatoma Activity in vitro and Pharmacokinetics in vivo

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