Hyaluronic acid coated poly(butyl cyanoacrylate) nanoparticles as anticancer drug carriers

He, Miao; Zhao, Ziming; Yin, Lichen; Tang, Cui; Chen, Yin

doi:10.1016/j.ijpharm.2009.02.012

Cited by 103 publications

(52 citation statements)

References 26 publications

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“…9 More notably, polymeric nanoparticles could improve the pharmacokinetic and distribution profile (such as longer blood circulation), reduce side effects, and target tumors by enhanced permeability and retention (EPR) effect-based passive mechanisms. [10][11][12] Hyaluronic acid (HA) has gained intense attention due to its superior properties and potential as a drug delivery carrier. HA is a water-soluble, biocompatible, and biodegradable linear polysaccharide formed by alternating D-glucuronic acid and N-acetyl-D-glucosamine units.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid

Yao¹,

Li²,

Sun³

et al. 2014

IJN

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In order to enhance the in vivo codelivery efficiency of gambogic acid (GA) and all-trans retinoic acid (ATRA), our strategy was to entrap GA in the self-assembled nanoparticles based on amphiphilic hyaluronic acid (HA)-ATRA (HRA) conjugate. In this way, GA and ATRA were loaded simultaneously in a nanocarrier and codelivered into the tumor cell through HA receptor-mediated endocytosis. GA-loaded HRA nanoparticles (GA-HRA) were prepared by a dialysis method, and their physicochemical characteristics were investigated as well. GA-HRA exhibited a high drug loading capacity (31.1%), had a particle size in the range of 100–150 nm, and good biocompatibility. HRA nanoparticles were effectively internalized by MCF-7 cells and translocated into the nucleus in a time-dependent manner. The in vivo imaging analysis demonstrated that the fluorescent signals in the tumor were markedly increased with DiR-loaded nanoparticles after intravenous administration compared to free DiR solution, suggesting it has excellent tumor targeting properties. More importantly, GA-HRA exhibited excellent in vivo efficacy with dramatically reduced toxicity. In conclusion, with the assistance of HRA nanoparticles, GA and ATRA can successfully realize an effective combination chemotherapy as well as tumor-targeted delivery.

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Section: Introductionmentioning

confidence: 99%

Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid

Yao¹,

Li²,

Sun³

et al. 2014

IJN

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“…Hyung et al (2008) demonstrated the efficacy of HA-coated drug carriers by delivering doxorubicin to MDA-MB-231 and ZR-75-1 human BCA cell lines (Hyung et al, 2008). Similarly, after coating nanoparticles containing paclitaxel with HA, cytotoxicity is reduced while cellular uptake of the drug by S-180 sarcoma cell line is enhanced 9.5 fold in vitro and in a mouse model (He et al, 2009). In light of fairly recent evidence for the display of CD44 on BCA tumour initiator cells, interest in developing CD44 targeted therapies has increased.…”

Section: Ha and Receptor Antagonists In Clinical Trialsmentioning

confidence: 93%

Hyaluronan Associated Inflammation and Microenvironment Remodelling Influences Breast Cancer Progression

Ward¹,

Vásquez²,

Tölg³

et al. 2011

Breast Cancer - Focusing Tumor Microenvironment, Stem Cells and Metastasis

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“…Many research groups have already worked on the synthesis of HA block copolymers, via different coupling methods; for instance, the HA-poly(butyl cyanoacrylate) (HA-PBCA) block copolymer, previously reported by He et al was prepared through redox radical emulsion polymerization. 15 However, polymeric nanoparticles formed from a single polymer often lack multiple functionalities, due to the limitation in the number of building blocks. In order to overcome this limitation, the polymeric nanoparticles consisting of more than one amphiphilic polymer have aroused great interest recently.…”

Section: Abbad Et Almentioning

confidence: 99%

“…The particle size of HA-PBCA nanoparticles reported by He et al was mainly dependent on the MW of HA, the cerium ammonium nitrate concentration, and the HA to BCA ratio. 15 It is well know that small micelle size is expected to prevent uptake by the reticuloendothelial system and facilitates extravasation at leaky sites of capillaries, leading to passive accumulation in certain tissues, eg, tumors. 37 However, the particle size reported by the group was larger than 290 nm, which was not favorable for drug-targeting.…”

Section: +4mentioning

confidence: 99%

Preparation, in vitro and in vivo evaluation of polymeric nanoparticles based on hyaluronic acid-poly(butyl cyanoacrylate) and D-alpha-tocopheryl polyethylene glycol 1000 succinate for tumor-targeted delivery of morin hydrate

Abbad¹,

Wang²,

Waddad³

et al. 2015

IJN

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Herein, we describe the preparation of a targeted cellular delivery system for morin hydrate (MH), based on a low-molecular-weight hyaluronic acid-poly(butyl cyanoacrylate) (HA-PBCA) block copolymer. In order to enhance the therapeutic effect of MH, D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) was mixed with HA-PBCA during the preparation process. The MH-loaded HA-PBCA “plain” nanoparticle (MH-PNs) and HA-PBCA/TPGS “mixed” nanoparticles (MH-MNs) were concomitantly characterized in terms of loading efficiency, particle size, zeta potential, critical aggregation concentration, and morphology. The obtained MH-PNs and MH-MNs exhibited a spherical morphology with a negative zeta potential and a particle size less than 200 nm, favorable for drug targeting. Remarkably, the addition of TPGS resulted in about 1.6-fold increase in drug-loading. The in vitro cell viability experiment revealed that MH-MNs enhanced the cytotoxicity of MH in A549 cells compared with MH solution and MH-PNs. Furthermore, blank MNs containing TPGS exhibited selective cytotoxic effects against cancer cells without diminishing the viability of normal cells. In addition, the cellular uptake study indicated that MNs resulted in 2.28-fold higher cellular uptake than that of PNs, in A549 cells. The CD44 receptor competitive inhibition and the internalization pathway studies suggested that the internalization mechanism of the nanoparticles was mediated mainly by the CD44 receptors through a clathrin-dependent endocytic pathway. More importantly, MH-MNs exhibited a higher in vivo antitumor potency and induced more tumor cell apoptosis than did MH-PNs, following intravenous administration to S180 tumor-bearing mice. Overall, the results imply that the developed nanoparticles are promising vehicles for the targeted delivery of lipophilic anticancer drugs.

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Hyaluronic acid coated poly(butyl cyanoacrylate) nanoparticles as anticancer drug carriers

Cited by 103 publications

References 26 publications

Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid

Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid

Hyaluronan Associated Inflammation and Microenvironment Remodelling Influences Breast Cancer Progression

Preparation, in vitro and in vivo evaluation of polymeric nanoparticles based on hyaluronic acid-poly(butyl cyanoacrylate) and D-alpha-tocopheryl polyethylene glycol 1000 succinate for tumor-targeted delivery of morin hydrate

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