Hyaluronic acid concentration in postmenopausal facial skin after topical estradiol and genistein treatment

Patriarca, Marisa Teresinha; Moraes, Andréa Regina Barbosa de; Nader, Helena B.; Pagani, Valeria; Martins, João Roberto Maciel; Gomes, Regina Célia Teixeira; Soares, José Maria

doi:10.1097/gme.0b013e318269898c

Cited by 36 publications

(34 citation statements)

References 30 publications

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“…This is in agreement with the findings that estrogen specifically and preferentially promotes HA expression in skin cells [30] and hCG induces HAS2 and HA in murine granular cells during the ovulatory process [31]. Hormone-induced HA secretion of DSCs was dose-associated, peaking at a physiological level observed in human early pregnancy.…”

Section: Discussionsupporting

confidence: 91%

Hyaluronan-CD44 Interaction Promotes Growth of Decidual Stromal Cells in Human First-Trimester Pregnancy

et al. 2013

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Hyaluronan (HA) and its receptor CD44 are expressed at the maternal-fetal interface, but its role in early pregnancy remains unclear. Here, we found that primary decidual stromal cells (DSCs) continuously secreted HA and expressed its receptor CD44. Pregnancy-associated hormones up-regulated HA synthetase (HAS) 2 transcription and HA release from DSCs. High molecular weight-HA (HMW-HA), but not medium molecular weight (MMW-HA) or low molecular weight (LMW-HA), promoted proliferation and inhibited apoptosis of DSCs in a CD44-dependent manner. The in-cell Western analysis revealed HMW-HA activated PI3K/AKT and mitogen-activated protein kinase (MAPK)/ERK1/2 signaling pathways time-dependently. Blocking these pathways by specific inhibitor LY294002 or U0126 abrogated HMW-HA-regulated DSc proliferation and apoptosis. Finally, we have found that HA content, HA molecular weight, HAS2 mRNA level, and CD44 expression were significantly decreased in DSCs from unexplained miscarriage compared with the normal pregnancy. Collectively, our results indicate that higher level and greater molecular mass of HA at maternal-fetal interface contributes to DSc growth and maintenance of DSCs in human early pregnancy.

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Section: Discussionsupporting

confidence: 91%

Hyaluronan-CD44 Interaction Promotes Growth of Decidual Stromal Cells in Human First-Trimester Pregnancy

et al. 2013

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“…It is reported that long-term application of estrogen increases HA expression in human facial skin [44]. In ovariectomized mice, dermal thickness and decorin expression were found to be reduced [45].…”

Section: Changes In Sulfated Gags and Pgsmentioning

confidence: 98%

Glycosaminoglycan and proteoglycan in skin aging

Lee

Chung

2016

Journal of Dermatological Science

184

151

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“…Phytoestrogens are mainly derived from natural plants and foods. In recent years, phytoestrogens have become a research hotspot in the fight against skin aging (Patriarca et al, ; Sirotkin & Harrath, ; Tuntiyasawasdikul, Limpongsa, Jaipakdee, & Sripanidkulchai, ). Phytoestrogens can increase collagen and hyaluronic acid production and have antioxidant, anti‐inflammatory, and other effects.…”

Section: Discussionmentioning

confidence: 99%

“…Soy isoflavone extract ISO‐1 (containing 12 soy isoflavones) from soybean cake was demonstrated to prevent skin damage caused by UVB exposure. The researchers found that soy isoflavones (daidzin, genistin and glycitin) could inhibit UVB‐induced death of human keratinocytes and reduce the level of desquamation, TEWL, erythema, and epidermal thickness in mouse skin (Huang et al, ; Patriarca et al, ).…”

Section: Effect On Water Contentmentioning

confidence: 99%

“…Phytoestrogens exert an anti‐aging effect on the skin via estrogen receptors (Gopaul, Knaggs, & Lephart, ). They increase the collagen content (Chua, Lee, Abdullah, & Sarmidi, ), the production of hyaluronic acid (Patriarca et al, ), and extracellular matrix proteins (Gopaul et al, ). Phytoestrogens show protection against oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

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Recent advances in the anti‐aging effects of phytoestrogens on collagen, water content, and oxidative stress

Liu

Yan

et al. 2019

Phytotherapy Research

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Skin undergoes degenerative changes as it ages, which include the loss of elasticity, reductions in the epidermal thickness and collagen content, elastic fiber degeneration, and increased wrinkling and dryness. Skin aging can be significantly delayed by the administration of estrogen. Estrogen deficiency following menopause results in atrophic skin changes and the acceleration of skin aging. Estrogen administration has positive effects on human skin by delaying or preventing skin aging manifestations, but the use of estrogen replacement is a risk factor for breast and uterine cancer. Phytoestrogens are a large family of plant‐derived molecules possessing various degrees of estrogen‐like activity; they exhibit agonist or antagonist estrogenic properties depending on the tissue. These molecules could be ideal candidates to combat skin aging and other detrimental effects of hypoestrogenism. In this paper, we review the effects of phytoestrogens on human skin and the mechanisms by which phytoestrogens can alleviate the changes due to aging.

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Hyaluronic acid concentration in postmenopausal facial skin after topical estradiol and genistein treatment

Abstract: Our data suggest that both treatments may enhance HA concentration in postmenopausal skin but that estrogen produces results that are greater than those produced by isoflavones.

Cited by 36 publications

References 30 publications

Hyaluronan-CD44 Interaction Promotes Growth of Decidual Stromal Cells in Human First-Trimester Pregnancy

Hyaluronan-CD44 Interaction Promotes Growth of Decidual Stromal Cells in Human First-Trimester Pregnancy

Glycosaminoglycan and proteoglycan in skin aging

Recent advances in the anti‐aging effects of phytoestrogens on collagen, water content, and oxidative stress

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