Hyaluronic acid covers in burn treatment: a systematic review

Abstract

OBJECTIVE To evaluate the effectiveness of hyaluronic acid in the healing of partial thickness burns. METHOD Systematic review of randomized controlled trials on the use of hyaluronic acid for the topical treatment of skin burns, based on recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. RESULTS Two randomized controlled trials that analyzed 143 patients with partial thickness burns and/or deep partial thickness burns were selected. They compared the application of hyaluronic acid 0.2% associated to silver sulfadiazine 1% 5g/cm2 versus silver sulfadiazine 1% 5g/cm2 alone for the outcome of complete healing. CONCLUSION This review emphasizes the need for new well-designed randomized controlled trials to establish the therapeutic relevance of hyaluronic acid with respect to the healing of burns of partial thickness or deep partial thickness.

Combination of Hyaluronan and Lyophilized Progenitor Cell Derivatives: Stabilization of Functional Hydrogel Products for Therapeutic Management of Tendinous Tissue Disorders

“…Hyaluronan-based hydrogels have historically been widely used in cutaneous and musculoskeletal regenerative medicine, due to an excellent biocompatibility, a high polyvalence in formulation possibilities, a wide tunability, and the potential for designing of diverse functionalities [1][2][3][4][5]. Specifically, such hydrogel therapeutic products or devices have been applied for the management of sub-critical cartilage, bone, and tendon tissue affections such as acute trauma, degenerative pathologies, and related symptoms, or of skin conditions and wounds [6][7][8][9][10][11][12]. Extensive evidence has been reported around the various therapeutic and the ancillary uses of hyaluronic acid (HA) and its derivatives in diverse categories of commercial products comprising pharmaceuticals, complex biologicals, cosmeceuticals, and cosmetics [13][14][15][16][17].…”

An Overview on Thermosensitive Oral Gel Based on Poloxamer 407

“…HA is a high-molecular-weight glycosaminoglycan (GAG) comprising a disaccharide non-sulfated unit repeat of D-glucuronic acid and N-acetylglucosamine. HA is a very important biomolecule because it is one of the main components of the extracellular matrix and is widely distributed in various tissues, including skin [ 48 ], synovial fluid, cartilage, tendons, eyes, and most body fluids [ 49 ]. As HA is involved in several biological processes related to morphogenesis and tissue healing as well as its biocompatibility, biodegradability, and non-immunogenicity [ 50 ], hyaluronic acid acts by promoting the enhancement of gel structure through hydrogen bonding between polymers.…”

Hyaluronic Acid: Prospective Use in Gynaecology

“…В настоящее время ПГК признаны безопасными и эффективными средствами для восстановления кожи: они уменьшают выраженность рубцевания и способствуют регенерации и заживлению тканей за счет стимуляции пролиферации и дифференцировки фибробластов, что приводит к увеличению содержания коллагена, гликозаминогликанов и гиалуронана кожи [6][7][8][9][10][11].…”