Hyaluronic acid derivative-coated nanohybrid liposomes for cancer imaging and drug delivery

GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment

“…In addition, the particle sizes could be maintained stably in serum for 24 hours (Figure 3B and treatment. Furthermore, the drug release data showed that there was more Endostar released at pH 5.0, which is similar to the pH of the tumor microenvironment, 33 compared to pH 7.4, suggesting intelligently controlled release of drugs and potential enhancement of antitumor efficacy with the GPENs (Figure 3A).…”

“…Almost 80% of the loaded Endostar remained enveloped in the nanoparticles after 96 hours, and the drug release was 22.67%±1.67%. In contrast, at pH 5.0, which is similar to the tumor microenvironment, 33 the release efficiency of Endostar from GPENs was slightly faster than at pH 7.4, reaching approximately 30.62%±4.02% after 96 hours. Drug release capability was increased at pH 5.0 compared to pH 7.4, indicating that drug release was accelerated in the acidic tumor environment.…”

Paclitaxel-loaded hyaluronan solid nanoemulsions for enhanced treatment efficacy in ovarian cancer

“…However, using nanocarriers with a high MTD to deliver PTX may permit the administration of Taxol at high doses for preclinical and/or clinical use as an anticancer agent. 7 For these reasons, new formulations such as liposomes, nanoparticles, lipid nanoparticles, and polymeric micelles have been investigated to enhance the targeted delivery of PTX; 6,[8][9][10] however, most of the formulations have not been used clinically. Among these, Abraxane ® is a successful commercial formulation.…”

GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment

“…Almost 80% of the loaded Endostar remained enveloped in the nanoparticles after 96 hours, and the drug release was 22.67%±1.67%. In contrast, at pH 5.0, which is similar to the tumor microenvironment, 33 …”