Hyaluronic acid electrospinning: Challenges, applications in wound dressings and new perspectives

Castro, Karine Cappuccio de; Campos, Maria Gabriela Nogueira; Mei, Lucía Helena Innocentini

doi:10.1016/j.ijbiomac.2021.01.100

Cited by 82 publications

(31 citation statements)

References 88 publications

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“…Among them, hyaluronic acid (HA) is a natural non-sulphated glycosaminoglycan, a major component of the extracellular matrix and gets involved in inflammatory response, angiogenesis and tissue regeneration [ 17 , 18 ]. HA has superior biocompatibility, biodegradability and easy to be chemically modified, which plays an important role in the process of wound healing [ 19 , 20 ]. A phenol-rich hyaluronic acid polymer has been of great interest for the development of in situ forming and injectable hydrogels enzymatically cross-linked by horseradish peroxidase (HRP) and galactose oxidase (GalOx) due to the controllable gelation rate, high specificity, and sensitive to outer condition changes.…”

Section: Introductionmentioning

confidence: 99%

Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment

Wang

Zhang

Ren

et al. 2022

Materials Today Bio

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Injectable hydrogel has the advantage to fill the defective area and thereby shows promise as therapeutic implant or cell/drug delivery vehicle for tissue repair. In this study, an injectable hyaluronic acid hydrogel in situ dual-enzymatically cross-linked by galactose oxidase (GalOx) and horseradish peroxidase (HRP) was synthesized and optimized, and the therapeutic effect of this hydrogel encapsulated with bone mesenchymal stem cells (BMSC) and nerve growth factors (NGF) for traumatic brain injury (TBI) mice was investigated. Results from in vitro experiments showed that either tyramine-modified hyaluronic acid hydrogels (HT) or NGF loaded HT hydrogels (HT/NGF) possessed good biocompatibility. More importantly, the HT hydrogels loaded with BMSC and NGF could facilitate the survival and proliferation of endogenous neural cells probably by neurotrophic factors release and neuroinflammation regulation, and consequently improved the neurological function recovery and accelerated the repair process in a C57BL/6 TBI mice model. All these findings highlight that this injectable, BMSC and NGF-laden HT hydrogel has enormous potential for TBI and other tissue repair therapy.

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Section: Introductionmentioning

confidence: 99%

Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment

Wang

Zhang

Ren

et al. 2022

Materials Today Bio

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“…Polymeric scaffolds have gained much attention over the last two decades. ,, In this context, the fabrication of polymeric architectures aiming at the native tissues has been one of the main challenges in the field. For this purpose, several methods have been developed and refined to generate nanoscale scaffolds as ECM substitutes, such as molding, microfluidics, phase separation, drawing, and electrospinning. ,, Among these methods, electrospinning has been consolidated as a simple, versatile and cost-effective technique to produce ultrathin and nanofibers from a wide range of polymers. , Because of its intrinsic high porosity and interconnectivity, electrospun fibers have been the target of many applications in the biomedical field, including drug delivery, , tissue engineering, ,, and wound dressing. − …”

Section: Introductionmentioning

confidence: 99%

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Deus

França

Forero

et al. 2021

ACS Appl. Mater. Interfaces

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The ability of mimicking the extracellular matrix architecture has gained electrospun scaffolds a prominent space into the tissue engineering field. The high surface-to-volume aspect ratio of nanofibers increases their bioactivity while enhancing the bonding strength with the host tissue. Over the years, numerous polyesters, such as poly(lactic acid) (PLA), have been consolidated as excellent matrices for biomedical applications. However, this class of polymers usually has a high hydrophobic character, which limits cell attachment and proliferation, and therefore decreases biological interactions. In this way, functionalization of polyester-based materials is often performed in order to modify their interfacial free energy and achieve more hydrophilic surfaces. Herein, we report the preparation, characterization, and in vitro assessment of electrospun PLA fibers with low contents (0.1 wt %) of different curcuminoids featuring π-conjugated systems, and a central β-diketone unit, including curcumin itself. We evaluated the potential of these materials for photochemical and biomedical purposes. For this, we investigated their optical properties, water contact angle, and surface features while assessing their in vitro behavior using SH-SY5Y cells. Our results demonstrate the successful generation of homogeneous and defect-free fluorescent fibers, which are noncytotoxic, exhibit enhanced hydrophilicity, and as such greater cell adhesion and proliferation toward neuroblastoma cells. The unexpected tailoring of the scaffolds’ interfacial free energy has been associated with the strong interactions between the PLA hydrophobic sites and the nonpolar groups from curcuminoids, which indicate its role for releasing hydrophilic sites from both parts. This investigation reveals a straightforward approach to produce photoluminescent 3D-scaffolds with enhanced biological properties by using a polymer that is essentially hydrophobic combined with the low contents of photoactive and multifunctional curcuminoids

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“…Electrospinning of hyaluronans is very challenging due to their high solution viscosity and high surface tension [ 23 , 268 ]. Although, to the best of our knowledge, there are no reports yet on marine-derived hyaluronic acid nanofibers, their utilization in electrospun fibrous scaffolds is expected to be feasible and very promising, since in recent years there has been an increasing interest in hyaluronic acid-based electrospun nanofibers [ 20 , 23 , 119 , 268 ]. Recently, Abdel-Mohsen et al (2019) developed electrospun nanofibers of hyaluronan/PVA loaded with silver nanoparticles.…”

Section: Marine Animal-derived Biopolymersmentioning

confidence: 99%

“…The spinning solutions of marine biopolymers are usually characterized by high electric conductivity, high viscosity, and high surface tension, which limit their spinning processability. The addition of surfactants—such as Triton-X-100, Pluronic F127, and lecithin—in the spinning solutions is a common strategy to reduce surface tension, increase biopolymer content, and facilitate the production of smooth nanofibers devoid of beads [ 21 , 22 , 23 ]. Another limitation concerning the application of marine biopolymeric fibers is their usually poor mechanical properties and fast degradation in aqueous media.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the hydrophilic nature of most marine biopolymers, various crosslinking treatments are often applied to provide the desired mechanical stability for applications where longevity in aqueous media is necessary. Different physical and chemical crosslinking methodologies have been reported in the literature, with polyelectrolyte complexation and exposure to glutaraldehyde vapors being the most widely employed crosslinking strategies to stabilize and reinforce marine-based nanofibrous scaffolds [ 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

et al. 2022

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Marine biopolymers, abundantly present in seaweeds and marine animals, feature diverse structures and functionalities, and possess a wide range of beneficial biological activities. Characterized by high biocompatibility and biodegradability, as well as unique physicochemical properties, marine biopolymers are attracting a constantly increasing interest for the development of advanced systems for applications in the biomedical field. The development of electrospinning offers an innovative technological platform for the production of nonwoven nanofibrous scaffolds with increased surface area, high encapsulation efficacy, intrinsic interconnectivity, and structural analogy to the natural extracellular matrix. Marine biopolymer-based electrospun nanofibrous scaffolds with multifunctional characteristics and tunable mechanical properties now attract significant attention for biomedical applications, such as tissue engineering, drug delivery, and wound healing. The present review, covering the literature up to the end of 2021, highlights the advancements in the development of marine biopolymer-based electrospun nanofibers for their utilization as cell proliferation scaffolds, bioadhesives, release modifiers, and wound dressings.

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Hyaluronic acid electrospinning: Challenges, applications in wound dressings and new perspectives

Cited by 82 publications

References 88 publications

Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment

Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

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