Hyaluronic Acid Fillers Enriched with Glycine and Proline in Eyebrow Augmentation Procedure

Abstract

Background The eyebrow area is a clinically critical district due to the anatomical complexity and the propensity to aging-related atrophy. Hyaluronic acid fillers have been proposed to recover the dermal volume of the facial and lips regions. Aim The aim of the present investigation was to evaluate hyaluronic acid fillers enriched with glycine and proline for the treatment of eyebrow augmentation. Methods A total of 15 healthy patients were treated with eyebrow augmentation procedure. The distance between mid-bipupil to lateral eyebrow and mid-eyebrow to the medial eyebrow was measured before, immediately after treatment and at follow-up of 6 months. Results The healing period was uneventful, and no evidence of inflammation or swelling associated with the treatment was reported. No macroscopical alteration was reported in the surrounding tissues with no evidences of visible wheals or lumps in the treated sites at the follow-up. Before treatment, the angle was equal to 9.32 ± 0.2°, while after treatment it was 11.21 ± 0.4° (p < 0.01); after three and 6 weeks, it was, respectively, 10.66 ± 0.2° (p<0.05) and 10.02 ± 0.3°(p > 0.05). Conclusions The study results suggest that the hyaluronic acid fillers enriched with glycine and proline treatment resulted as being a useful procedure for augmentation, contour and volume definition and elevation of the eyebrow region with a high-level aesthetic result. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Retracted: The role of hyaluronic acid and amino acid against the aging of the human skin: A clinical and histological study

“…18 In the present study, we chose the fragments of hyaluronic acid between 20 and 38 monomers mixed with amino acids because they play an important role in the biomodulation of the dermis. [19][20][21][22][23][24][25][26] Hyaluronic acid is the most common glycosaminoglycan of the extracellular matrix and reaches its maximum concentration only in highly hydrated tissues, such as the vitreous fluid and the umbilical cord. 24 It is degraded into fragments by hyaluronidases that stimulate angiogenesis, tissue remodeling, and cell turnover.…”

Evaluation of short‐term face rejuvenation effects of non‐ablative bipolar radiofrequency treatment performed by Med‐RF©device

“…Nowadays, there is a great and widespread demand by patients to reduce the aging and photodamaging appearance by rejuvenation techniques, as a widespread and accepted cosmetic procedure 19–21 . In cosmetic surgery, face surgical liftings have represented the gold standard for skin laxity, with the drawbacks of costs, risks and complications 22,23 .…”

“…In cosmetic surgery, face surgical liftings have represented the gold standard for skin laxity, with the drawbacks of costs, risks and complications 22,23 . Alternative to surgery, but also associated with significant side effects (e.g., prolonged and unpleasant post‐treatment downtime), ablative fractional and non‐ablative laser resurfacing have been applied, 5,23–28 as well as cosmetic practices using injectable compounds (fillers) 20,29–34 . Then, in recent years, totally non‐invasive procedures have become an appealing option, strongly supported by the market claim of safety and effectiveness 35,36 …”

“…Nowadays, there is a great and widespread demand by patients to reduce the aging and photodamaging appearance by rejuvenation techniques, as a widespread and accepted cosmetic procedure. [19][20][21] In cosmetic surgery, face surgical liftings have represented the gold standard for skin laxity, with the drawbacks of costs, risks and complications. 22,23 Alternative to surgery, but also associated with significant side effects (e.g., prolonged and unpleasant post-treatment downtime), ablative fractional and non-ablative laser resurfacing have been applied, 5,[23][24][25][26][27][28] as well as cosmetic practices using injectable compounds (fillers).…”

“…22,23 Alternative to surgery, but also associated with significant side effects (e.g., prolonged and unpleasant post-treatment downtime), ablative fractional and non-ablative laser resurfacing have been applied, 5,[23][24][25][26][27][28] as well as cosmetic practices using injectable compounds (fillers). 20,[29][30][31][32][33][34] Then, in recent years, totally non-invasive procedures have become an appealing option, strongly supported by the market claim of safety and effectiveness . 35,36 Ablative lasers have been accepted as the gold standard for photodamaged skin rejuvenation for more than half of a decade and many different light sources and light-based systems have been developed and proven effective to reverse photodamage and age-associated skin degeneration without epidermal damage.…”