Hyaluronic acid for anticancer drug and nucleic acid delivery

Polymeric nanoparticles for colon cancer therapy: overview and perspectives

“…Hyaluronic (HA) nanoparticles also have been designed as drug delivery systems to target colon tumors. 115 Choi et al…”

Plaque-hyaluronidase-responsive high-density-lipoprotein-mimetic nanoparticles for multistage intimal-macrophage-targeted drug delivery and enhanced anti-atherosclerotic therapy

“…Unsurprisingly, ex vivo imaging confirmed the highest DiR presence in the aortic tree and the lowest signal intensity in the liver from atherosclerotic rabbits injected with DiR-HA-(C)-PLGA-rHDL, which could be explained by mainly two aspects: (i) the protective HA coating covalently immobilized on DiR-HA-(C)-PLGA-rHDL possessed "stealth" characters similar to hydrophilic material polyethylene glycol, 50 and maximized the shielding for apoA-I function so as to avoid the undesired internalization by liver in circulation; and (ii) with the aid of the high affinity of HA toward CD44 receptors up-regulated on damaged endothelial cells, DiR-HA-(C)-PLGA-rHDL was capable of vanquishing the drag of d-flow at atherosclerotic lesions, and various biological barriers for targeting iMΦ via the multistagetargeting mechanism. Most importantly, the strongest DiR signal specifically colocalized with CD68-stained iMΦ further corroborated the excellent targeting performance of DiR-HA-(C)-PLGA-rHDL on iMΦ at a cellular level; in accord with the observations from in vitro iMΦ-targeting experiments, insufficient HA surface coverage for masking apoA-I and the inferior stability of HA electrostatically attached to DiR-HA-(E)-PLGA-rHDL might help explain the higher distribution in liver and lower accumulation of DiR-HA-(E)-PLGA-rHDL in the iMΦ than that of DiR-HA-(C)-PLGA-rHDL; compared with other nanocarriers, a great deal of DiR-PLGA-rHDL and DiR-s-rHDL were phagocytosed by liver via SR-BI receptor-mediated pathway prior to being delivered into the target, thus resulting in the largest accumulation in liver and decreasing the distribution in iMΦ, which was analogous to the results in our previous study; besides, probably ascribed to the lipid bilayer conducive to internalization by cells, DiR-PLGA-rHDL exhibited slightly better iMΦ-targeting effect than DiR-s-rHDL; the inefficient passive targeting under the interference of d-flow and higher uptake by RES in circulation might presumably account for the weakest signal intensity of DiR-PLN in iMΦ; because of lack of specificity, free DiR almost had no deposition in the iMΦ of atherosclerotic lesions.…”

Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application

“…HA has been proposed as an alternative to polyethylene glycol to improve the pharmacokinetic properties of therapeutic agents. [40][41][42] Therefore, the drug delivery system could partially evade accumulation in the liver through the decoration of HA on the nanosheets. As shown in Figure 11A(c) and B, distinct whitening at the tumor locations according to the T1-weighted MRI following the 4-hour administration was detected.…”