Hyaluronic acid formulation of near infrared fluorophores optimizes surgical imaging in a prostate tumor xenograft

Souchek, Joshua J.; Wojtynek, Nicholas E.; Payne, William M.; Holmes, Megan B.; Dutta, Samikshan; Qi, Bowen; Datta, Kaustubh; LaGrange, Chad A.; Mohs, Aaron M.

doi:10.1016/j.actbio.2018.06.016

Cited by 32 publications

(20 citation statements)

References 41 publications

(70 reference statements)

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“…2019, 31,1904329 HFR-eNPs 565-700 nm [128] 2018 NanoCy7.5 100k-PBA 800-900 nm [129] OTL38 793 nm [130] Turn-ON probes 670 nm [131] 2019 THQ-Rosol 710 nm [132] RVG&IRDye800-Gd2O3 TNs 806 nm [133] SWNT-CY7-IGF-1Ra 770 nm [134] www.advmat.de www.advancedsciencenews.com Adv. Mater.…”

Section: Surface-enhanced Raman Spectroscopymentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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Section: Surface-enhanced Raman Spectroscopymentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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“…Hydrophobic and amphiphilic molecules, such as ICG, can be loaded into HA‐PBA NPs and retained in the hydrophobic pockets through π–π stacking (Svechkarev, Kyrychenko, Payne, & Mohs, ). Compared to free ICG, NanoICG provided up to 2.9‐fold higher intraoperative contrast and improved surgical outcomes in breast, pancreatic, and prostate tumors (Hill et al, , ; Qi, Chen, et al, ; Souchek et al, ; Wojtynek et al, ). Others have improved the tumor uptake of ICG with active targeting ligands.…”

Section: Nanoparticle Strategies For Image‐guided Surgerymentioning

confidence: 99%

“…Compared to free Cy7.5, NanoCy7.5 provided 14.8‐fold higher contrast in breast tumors. This is a product of not only the high QY of Cy7.5 but also direct conjugation of the dye to the HA NP, minimizing the amount of free Cy7.5 escaping from the nanoformulation (Hill et al, ; Kelkar et al, ; Souchek et al, ). Also, NanoCy7.5 was combined with HA‐PBA‐GdDTPA in a mixed‐micelle formulation, termed self‐assembled multimodal imaging NPs (SAMINs), for dual‐modality MRI‐NIRF imaging of breast tumors.…”

Section: Nanoparticle Strategies For Image‐guided Surgerymentioning

confidence: 99%

Image‐guided tumor surgery: The emerging role of nanotechnology

Wojtynek

Mohs

2020

WIREs Nanomed Nanobiotechnol

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Surgical resection is a mainstay treatment for solid tumors. Yet, methods to distinguish malignant from healthy tissue are primarily limited to tactile and visual cues as well as the surgeon's experience. As a result, there is a possibility that a positive surgical margin (PSM) or the presence of residual tumor left behind after resection may occur. It is well‐documented that PSMs can negatively impact treatment outcomes and survival, as well as pose an economic burden. Therefore, surgical tumor imaging techniques have emerged as a promising method to decrease PSM rates. Nanoparticles (NPs) have unique characteristics to serve as optical contrast agents during image‐guided surgery (IGS). Recently, there has been tremendous growth in the volume and types of NPs used for IGS, including clinical trials. Herein, we describe the most recent contributions of nanotechnology for surgical tumor identification. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery Diagnostic Tools > in vivo Nanodiagnostics and Imaging

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“…HA-binding receptors, such as RHAMM and CD44, have been shown to be overexpressed on various cancer cell surfaces, further expanding the broad applicability of HA-based nanomedicines for active tumor-targeted drug delivery (Jiang et al., 2012 ). Additionally, HA exhibits low accumulation in liver because of weak specificity to its binding site in this organ, thereby promoting accumulation of HA-based nanomedicines in tumor tissue (Hwang et al., 2017 ; Souchek et al., 2018 ). Multiple stimuli-responsive nanomedicines based on HA have been developed for cancer therapy, such as an enzyme-responsive HA-based nanogel for drug delivery that is preferentially internalized by CD-44-overexpressing cancer cells (Yang et al., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance

et al. 2020

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Multidrug resistance (MDR) of cancer cells is a significant challenge in chemotherapy, highlighting the urgent medical need for simple and reproducible strategies to reverse this process. Here, we report the development of an active tumor-targeting and redox-responsive nanoplatform (PA-ss-NP) using hyaluronic acid- g -cystamine dihydrochloride-poly-ε-(benzyloxycarbonyl)-L-lysine (HA-ss-PLLZ) to co-deliver paclitaxel (PTX) and apatinib (APA) for effective reversal of MDR. This smart nanoplatform specifically bound to CD44 receptors, leading to selective accumulation at the tumor site and uptake by MCF-7/ADR cells. Under high concentrations of cellular glutathione (GSH), the nanocarrier was degraded rapidly with complete release of its encapsulated drugs. Released APA effectively inhibited the function of the P-glycoprotein (P-gp) drug pump and improved the sensitivity of MDR cells to chemotherapeutic agents, leading to the recovery of PTX chemosensitivity in MDR cells. As expected, this newly developed intelligent drug delivery system could effectively control MDR, both in vitro and in vivo .

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Hyaluronic acid formulation of near infrared fluorophores optimizes surgical imaging in a prostate tumor xenograft

Cited by 32 publications

References 41 publications

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Image‐guided tumor surgery: The emerging role of nanotechnology

Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance

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