Hyaluronic Acid Gel Incorporating Curcumin-Phospholipid Complex Nanoparticles Prevents Postoperative Peritoneal Adhesion

Akhlaghi, Sarah; Rabbani, Shahram; Karimi, Hanieh; Haeri, Azadeh

doi:10.1016/j.xphs.2022.10.022

Cited by 6 publications

(9 citation statements)

References 61 publications

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“…Various biomaterials, such as chitosan and derivative [ 179 ], hyaluronic acid(HA) [ 180 , 181 ], poly(ethylene glycol) (PEG) [ 182 , 183 ], gelatin [ 184 ], dextran (DEX) and derivative [ 185 ], PEO [ 186 ], and etc., have been prepared into hydrogels and demonstrated their efficiency in reducing POA. However, some extent of adhesion could still be founded because of their low mechanical strength.…”

Section: Possible Strategies For Preventing Adhesion By Using Biomate...mentioning

confidence: 99%

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Liao

Fan

2023

Bioactive Materials

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Section: Possible Strategies For Preventing Adhesion By Using Biomate...mentioning

confidence: 99%

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Liao

Fan

2023

Bioactive Materials

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“…The CPC was synthesized using the solvent evaporation method (13,21) with a molar ratio of 1:2 for crocin to EPC.…”

Section: Preparation Of Cpcmentioning

confidence: 99%

“…As a key component of cell membranes, this amphiphilic lipid can form lipid bilayers. The amphiphilic nature of phospholipids, with a phosphate head and two hydrophobic tails (Figure 1C), allows for the formation of phospholipid-based complexes through covalent or non-covalent interactions, potentially leading to enhanced oral bioavailability and reduced drug leakage (11)(12)(13). The technology of drug-phospholipid complexes has been successfully applied in recent years to improve the characteristics of natural substances, including chrysin (14), piperine (15), and luteolin (16).…”

mentioning

confidence: 99%

Crocin-Phospholipid Complex: Molecular Docking, Molecular Dynamics Simulation, Preparation, Characterization, and Antioxidant Activity

Rezaee,

Karami

et al. 2024

Iran J Pharm Res

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Background: Crocin is a water-soluble carotenoid compound present in saffron (Crocus sativus L.), known for its wide range of pharmacological activities, including cardioprotective, hepatoprotective, anti-tumorigenic, anti-atherosclerosis, and anti-inflammatory effects. Objectives: The instability of crocin, its low miscibility with oils, and poor bioavailability pose challenges for its pharmaceutical applications. This study aimed to design and prepare a crocin-phospholipid complex (CPC) and assess its physicochemical properties. Methods: The study investigated the formation of the complex and its binding affinity through molecular docking. Molecular dynamics (MD) simulations were conducted to find the optimal molar ratio of crocin to phospholipid for the complex's preparation. The CPC was produced using the solvent evaporation method. Techniques such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), field-emission scanning electron microscopy (FE-SEM), nuclear magnetic resonance (NMR), and solubility studies were utilized to characterize and confirm the formation of CPC. Additionally, the in vitro antioxidant activity of crocin and CPC was evaluated. Results: Molecular dynamic simulations explored molar ratios of 1: 1, 1: 1.5, and 1: 2 for crocin to phospholipid. The ratio of 1: 2 was found to be the most stable, exhibiting the highest probability of hydrogen bond formation. Molecular docking, FTIR, and NMR studies indicated hydrogen bond interactions between crocin and phospholipid, confirming CPC's formation. XRD and FE-SEM analyses showed a decrease in crocin's crystallinity within the phospholipid complex. Furthermore, the solubility of crocin in n-octanol was enhanced post-complexation, indicating an increase in crocin's lipophilic nature. Conclusions: Phospholipid complexation emerges as a promising technique for enhancing the physicochemical characteristics of crocin.

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“…Curcumin plays a significant role in decreasing inflammation as its mechanism of action promotes the deactivation of NF-κb, 24 indicating a key role in the inflammatory process and a decrease in the production of inflammatory mediators. 25 TA is a compound that has shown both anti-inflammatory 26 and anti-fibrotic properties, reducing the expression of TGF-β. 27 Thus, we hypothesize that the codelivery of curcumin and TA by our nanoformulation would tackle the problem of inflammation and excessive fibrosis in tendinitis.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Curcumin, a natural polyphenol turmeric derived from Curcuma longa, was selected due to its anti-inflammatory capabilities. Curcumin plays a significant role in decreasing inflammation as its mechanism of action promotes the deactivation of NF-κb, indicating a key role in the inflammatory process and a decrease in the production of inflammatory mediators . TA is a compound that has shown both anti-inflammatory and anti-fibrotic properties, reducing the expression of TGF-β .…”

Section: Introductionmentioning

confidence: 99%

In Vitro Study of the Anti-inflammatory and Antifibrotic Activity of Tannic Acid-Coated Curcumin-Loaded Nanoparticles in Human Tenocytes

Molinaro

Fontana

Tello

et al. 2023

ACS Appl. Mater. Interfaces

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Tendinitis is a tendon disorder related to inflammation and pain, due to an injury or overuse of the tissue, which is hypocellular and hypovascular, leading to limited repair which occurs in a disorganized deposition of extracellular matrix that leads to scar formation and fibrosis, ultimately resulting in impaired tendon integrity. Current conventional treatments are limited and often ineffective, highlighting the need for new therapeutic strategies. In this work, acetalated-dextran nanoparticles (AcDEX NPs) loaded with curcumin and coated with tannic acid (TA) are developed to exploit the anti-inflammatory and anti-fibrotic properties of the two compounds. For this purpose, a microfluidic technique was used in order to obtain particles with a precise size distribution, aiming to decrease the batch-to-batch variability for possible future clinical translation. Coating with TA increased not only the stability of the nanosystem in different media but also enhanced the interaction and the cell-uptake in primary human tenocytes and KG-1 macrophages. The nanosystem exhibited good biocompatibility toward these cell types and a good release profile in an inflammatory environment. The efficacy was demonstrated by real-time quantitative polymerase chain reaction, in which the curcumin loaded in the particles showed good anti-inflammatory properties by decreasing the expression of NF-κb and TAcoated NPs showing anti-fibrotic effect, decreasing the gene expression of TGF-β. Overall, due to the loading of curcumin and TA in the AcDEX NPs, and their synergistic activity, this nanosystem has promising properties for future application in tendinitis.

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Hyaluronic Acid Gel Incorporating Curcumin-Phospholipid Complex Nanoparticles Prevents Postoperative Peritoneal Adhesion

Cited by 6 publications

References 61 publications

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials: Based on the mechanisms of occurrence and development of adhesions

Crocin-Phospholipid Complex: Molecular Docking, Molecular Dynamics Simulation, Preparation, Characterization, and Antioxidant Activity

In Vitro Study of the Anti-inflammatory and Antifibrotic Activity of Tannic Acid-Coated Curcumin-Loaded Nanoparticles in Human Tenocytes

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