Hyaluronic Acid Gel (Restylane) Filler for Facial Rhytids: Lessons Learned From American Society of Ophthalmic Plastic and Reconstructive Surgery Member Treatment of 286 Patients

McCracken, Michael S.; Khan, Jemshed A.; Wulc, Allan E.; Holds, John B.; Fante, Robert G.; Migliori, Michael E.; Ebroon, Daniel A.; Amato, Malena; Silkiss, Rona Z.; Patel, Bhupendra C.

doi:10.1097/01.iop.0000217562.64529.ff

Cited by 43 publications

(36 citation statements)

References 2 publications

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“…The most commonly reported side effects for HAs are edema, erythema, ecchymosis, and pain, which may occur in approximately 5% of patients ( McCracken et al, 2006 ).…”

Section: Aes Associated With Hyaluronic Acidmentioning

confidence: 99%

Dermal Fillers and Volume Enhancers for Facial Rejuvenation

Brennan¹

2013

Plastic Surgical Nursing

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“…The most commonly reported side effects for HAs are edema, erythema, ecchymosis, and pain, which may occur in approximately 5% of patients ( McCracken et al, 2006 ).…”

Section: Aes Associated With Hyaluronic Acidmentioning

confidence: 99%

Dermal Fillers and Volume Enhancers for Facial Rejuvenation

Brennan¹

2013

Plastic Surgical Nursing

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“…The main reported adverse events were self-limited and occurred in approximately 5% of patients. Bruising, swelling, bumpiness, asymmetry, and redness were the most commonly reported complications [16].…”

Section: Restylanementioning

confidence: 99%

Hyaluronic Acid Fillers: Restylane and Perlane

Brandt

Cazzaniga

2007

Facial Plastic Surgery Clinics of North America

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“…Not specified/ not known [29] Retrospective study (n = 286), follow-up not specified Short-term complications in 14 subjects Not specified/ not known [87] Retrospective study 1999 (n = 144,000), follow-up not specified ‡ ‡ Localized hypersensitivity reactions occurring in approximately 1 of every 1400 patients treated. Short-term complications 1 of every 650 patient Product related [12] Retrospective study 2000 (n = 262,000), follow-up not specified ‡ ‡ Hypersensitivity occurred in 1 of every 5000 patients treated Product related [12] Hyaluronic acid (cross-linked)…”

Section: Hyaluronic Acid (Cross-linked)mentioning

confidence: 99%

Clinical data on injectable tissue fillers: a review

Vries

Geertsma

2013

Expert Review of Medical Devices

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Treatment with injectable tissue fillers for aesthetic purposes is increasingly popular. In parallel with this success, questions related to the safety of these treatments and the products involved are being raised more prominently. To gain insight in the safety aspects of injectable tissue fillers, we performed a literature review to collect studies reporting clinical data of injectable tissue fillers. We found several case reports where serious complications after more than three years are described. However, there are only a limited number of well-defined prospective clinical studies available with follow-up periods longer than three years. Furthermore, causes of complications, that is, treatment or product related, are often not specified in literature. Considering the intended functional period of fillers in combination with the known occurrence of long-term complications, there is a need for well-defined prospective clinical studies. In order to be able to discriminate between product failure (a product safety issue) or application methodology (a physician expertise or training issue), better identification of observed complications and whether they are product or treatment related, is needed. For the safe use of the fillers it is important that treatment with injectable tissue fillers is performed by a trained physician, who knows the product specifications and its applications. . Moreover, it is expected that due to increase in life expectancy, the demand for anti-aging treatments, like tissue augmentation with injectable tissue fillers, will grow [2]. Their success has been attributed to the fact that treatments with injectable tissue fillers are fast and appear to be relatively easy [2]. Only a relatively 'simple' subcutaneous injection is needed. Today, various injectable tissue fillers with different characteristics are available, for example, duration of the effect, material type and intended anatomical location.Although the application of an injectable tissue filler seems to be relatively simple and safe, reports of serious adverse effects have appeared in the literature [2][3][4][5][6][7][8]. Estimates of the occurrence of severe complications after treatment with various types of injectable tissue fillers range between 1:80 and 1:50,000 patients [9,10]. Adverse side effects can be caused by incorrect injection techniques (treatment related) or by the characteristics of the products (product related) [11,12]. Short-, mid-and long-term complications can be discerned (TABLE 1) [2,13-15]. Short-term complications like pain, swelling, fever, immediate hypersensitivity reactions, occur immediately or within several days past treatment and disappear after several weeks. A more severe short-term complication is necrosis [5,16]. Necrosis occurs immediately or within a few days if blood vessels are obstructed by the filler material or if they are injured during the treatment [17]. Mid-term complications such as delayed inflammatory reactions, ulceration and granuloma reaction may occur after 2-12 months. I...

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Hyaluronic Acid Gel (Restylane) Filler for Facial Rhytids: Lessons Learned From American Society of Ophthalmic Plastic and Reconstructive Surgery Member Treatment of 286 Patients

Cited by 43 publications

References 2 publications

Dermal Fillers and Volume Enhancers for Facial Rejuvenation

Dermal Fillers and Volume Enhancers for Facial Rejuvenation

Hyaluronic Acid Fillers: Restylane and Perlane

Clinical data on injectable tissue fillers: a review

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