Hyaluronic Acid Hydrogels Crosslinked in Physiological Conditions: Synthesis and Biomedical Applications

Pérez, Luis Andrés; Hernández, Rebeca; Alonso, José María Rabal; Pérez-González, Raúl; Sáez-Martínez, Virginia

doi:10.3390/biomedicines9091113

Cited by 83 publications

(73 citation statements)

References 126 publications

(235 reference statements)

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“…Native high molecular weight hyaluronic acid forms viscous hydrogels due its high hydrophilicity, but it undergoes rapid degradation under the action of enzymes in the body. Therefore, it needs to be modified using chemical cross-linking to obtain stable hydrogels [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogels on the Base of Modified Chitosan and Hyaluronic Acid Mix as Polymer Matrices for Cytostatics Delivery

Vil’danova

Лобов

Спирихин

et al. 2022

Gels

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The development of biodegradable polysaccharide hydrogel matrices for cytostatic delivery can improve the therapeutic results of patients by prolonging the action of the drug, reducing its toxicity and providing additional biological activity by polysaccharides. In this work, N-succinyl chitosan/hyaluronic acid dialdehyde/cytostatic formulations have been prepared using two different chitosan grades (30 kDa and 150 kDa) and hyaluronic acid dialdehyde. The interaction of amino groups of N-succinyl chitosan and aldehydes of hyaluronic acid resulted in the formation of azomethine bonds and was demonstrated using 13C NMR. The elastic properties of the obtained hydrogels determine their use as implants. Two cytostatics—5-fluorouracil and mitomycin C were chosen as drugs because of their using both in oncology and in ophthalmology for the surgical treatment of glaucoma. Hydrogel formulations containing cytostatic were prepared and drug release was studied using in vitro dialysis method. It was established that the molecular weight of N-succinyl chitosan and rheological properties of hydrogel influenced the drug release behavior of the gelling delivery system. Formulations prepared from N-succinyl chitosan with greatest molecular weight and mitomycin C were found to be the most promising for medical application due to their rheological properties and prolonged drug release. Mild preparation conditions, simplicity of the technique, short gelation time (within a minute), 100% yield of hydrogel, suitability for drug release applications are the main advantages of the obtained hydrogels.

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Section: Introductionmentioning

confidence: 99%

Hydrogels on the Base of Modified Chitosan and Hyaluronic Acid Mix as Polymer Matrices for Cytostatics Delivery

Vil’danova

Лобов

Спирихин

et al. 2022

Gels

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“…The latter results in the formation of active moieties, which add new functionalities to the hydrogel. The carboxyl group, hydroxyl group, and N-acetyl group (mainly carboxyl group) of HA disaccharide units are three sites that may undergo chemical modification ( Pérez et al, 2021 ). One alternative could be an antibacterial HA-based composite scenario, which needs further study and testing in a large-scale clinical trial according to regulatory requirements.…”

Section: Hyaluronic Acid Properties and Antibacterial Activitymentioning

confidence: 99%

“… A schematic illustration of the random conjugation of free amino groups of proteins to carboxylic groups of HA polymer. Adapted from refs ( Mero and Campisi, 2014 ) (61) ( Ghosh et al, 2017 ) (59) ( Jing and DeAngelis, 2000 ) (57) ( Prasad et al, 2012 ) (56) ( Chien and Lee, 2007 ) (54) ( Mao and Chen, 2007 ) (52) ( Mao et al, 2009 ) (51) ( Mao et al, 2009 ) (44) ( Shiedlin et al, 2004 ) (45) ( Pérez et al, 2021 ). …”

Section: Hyaluronic Acid As Carrier In Drug Delivery Systemsmentioning

confidence: 99%

Hyaluronic Acid-Based Nanomaterials as a New Approach to the Treatment and Prevention of Bacterial Infections

Alipoor

Ayan²,

Hamblin

et al. 2022

Front. Bioeng. Biotechnol.

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Bacterial contamination of medical devices is a great concern for public health and an increasing risk for hospital-acquired infections. The ongoing increase in antibiotic-resistant bacterial strains highlights the urgent need to find new effective alternatives to antibiotics. Hyaluronic acid (HA) is a valuable polymer in biomedical applications, partly due to its bactericidal effects on different platforms such as contact lenses, cleaning solutions, wound dressings, cosmetic formulations, etc. Because the pure form of HA is rapidly hydrolyzed, nanotechnology-based approaches have been investigated to improve its clinical utility. Moreover, a combination of HA with other bactericidal molecules could improve the antibacterial effects on drug-resistant bacterial strains, and improve the management of hard-to-heal wound infections. This review summarizes the structure, production, and properties of HA, and its various platforms as a carrier in drug delivery. Herein, we discuss recent works on numerous types of HA-based nanoparticles to overcome the limitations of traditional antibiotics in the treatment of bacterial infections. Advances in the fabrication of controlled release of antimicrobial agents from HA-based nanosystems can allow the complete eradication of pathogenic microorganisms.

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“…Hyaluronic acid (HA) is a natural polysaccharide—an anionic, non‐sulfated glycosaminoglycan made up of repeating units of the disaccharide β‐1,4‐D‐glucuronic acid‐β‐1,3 which is commonly found in the human body, especially in the skin, connective tissues, and synovial joint fluids (Abdallah et al, 2020; Pérez et al, 2021). HA has received great interest for its potential use in drug delivery given that it is negatively charged, biocompatible, biodegradable, and has low immunogenicity (Kim et al, 2019).…”

Section: Types Of Nanocarriers Used For Oral Insulin Deliverymentioning

confidence: 99%

Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management

Abdel-Moneim

Ramadan

2021

Drug Development Research

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Diabetes mellitus is one of the most serious public health problems in the world. Repeated daily injections of subcutaneous insulin is the standard treatment for patients with type 1 diabetes mellitus; however, subcutaneous insulin injections can potentially cause local discomfort, patient noncompliance, hypoglycemia, failure to regulate glucose homeostasis, infections, and fat deposits at the injection sites. In recent years, numerous attempts have been made to produce safe and efficient nanoparticles for oral insulin delivery. Oral administration is considered the most effective alternative route to insulin injection, but it is accompanied by several challenges related to enzymatic proteolysis, digestive breakdown, and absorption barriers. A number of natural and synthetic polymeric, lipid‐based, and inorganic nanoparticles have been investigated for use. Although improvements have recently been made in potential oral insulin delivery systems, these require further investigation before clinical trials are conducted. In this review, new approaches to oral insulin delivery for diabetes treatment are discussed, including polymeric, lipid‐based, and inorganic nanoparticles, as well as the clinical trials performed for this purpose.

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Hyaluronic Acid Hydrogels Crosslinked in Physiological Conditions: Synthesis and Biomedical Applications

Cited by 83 publications

References 126 publications

Hydrogels on the Base of Modified Chitosan and Hyaluronic Acid Mix as Polymer Matrices for Cytostatics Delivery

Hydrogels on the Base of Modified Chitosan and Hyaluronic Acid Mix as Polymer Matrices for Cytostatics Delivery

Hyaluronic Acid-Based Nanomaterials as a New Approach to the Treatment and Prevention of Bacterial Infections

Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management

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