Hyaluronic acid in the prevention of bronchial obstruction induced by hypertonic saline

Hyaluronic Acid Improves the Tolerability of Hypertonic Saline in the Chronic Treatment of Cystic Fibrosis Patients: A Multicenter, Randomized, Controlled Clinical Trial

“…(11)(12)(13)(14)(15) Single-dose studies have also shown that when HA is added to HS, it also improves the latter's tolerability. (16)(17)(18) In the present study, we tested our hypothesis that a formulation of HS with HA could be better tolerated than HS alone when given twice daily for 28 days to a group of patients who had previously shown intolerance to HS.…”

Impact of Hypertonic Saline Solutions on Sputum Expectoration and Their Safety Profile in Patients with Bronchiectasis: A Randomized Crossover Trial

“…A spirometry was performed pre-and postbronchodilator and again 5 minutes after completing the inhalation. (29) Participants with inhalation-induced bronchospasm (fall ‡12% FEV 1 ) (30) were not allowed to continue the remainder sessions of the same treatment arm; however, they continued the study trying the next saline solution according to the same schedule and procedure.…”

New Form of Hypertonic Solution for Nebulization Therapy

“…Исследования по применению даже однократной дозы продемонстрировали, что добавление 0,1% рас-твора гиалуроновой кислоты к гипертоническому раст-вору значительно повышает переносимость препарата [10][11][12]. Особенно эффективны подобные ингаляции у пациентов с бронхоэктазами, врожденными пороками развития бронхов и при муковисцидозе.…”