Hyaluronic Acid in the Third Millennium

Fallacara, Arianna; Baldini, Erika; Manfredini, Stefano; Vertuani, Silvia

doi:10.3390/polym10070701

Cited by 583 publications

(539 citation statements)

References 239 publications

(470 reference statements)

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“…Degradation of HA in the human body is performed by two different mechanisms: specific, mediated by the hyaluronidase enzymatic complex and non-specific, mediated by reactive oxygen species (oxidative damage) [40].…”

Section: Resultsmentioning

confidence: 99%

Melatonin and Hyaluronic Acid in Periodontal Disease

Cristache¹,

Totu²,

Cristache³

et al. 2019

Rev. Chim.

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The aim of the present paper was to highlight the individual effects of melatonin (MEL) and hyaluronic acid (HA) on periodontal structures and repair mechanism and to investigate a possible synergic effect and if each component of the proposed mixture (MEL-HA) would maintain their specific characteristics, when using booth active principles, for a topical application. A comprehensive review of the recent literature focusing on the role of MEL and HA in periodontal therapy, as well as on the use of both active compounds and possible synergic effect, have been conducted. An experimental investigation, using the FT-IR analysis, both the individual spectra of each component and the complex matrix obtained was performed. The experimental data obtained from our study proved that no structural changes occurred at the level of the functional groups of the components. Therefore, it is expected that the obtained formulation to be highly efficient for the treatment of periodontal disease, as it would combine the specific local action of MEL and HA.

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Section: Resultsmentioning

confidence: 99%

Melatonin and Hyaluronic Acid in Periodontal Disease

Cristache¹,

Totu²,

Cristache³

et al. 2019

Rev. Chim.

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“…From a clinical perspective, the rate of OVD removal may be dependent on the type of OVD employed (for example, Viscoat is of a smaller molecular weight and more dispersive compared to Healon5), the age of the patient and their metabolic rate, and the size of the OVD inoculation. The OVD degradation may also be dependent on the ocular inflammatory state, which could lead to local differences in pH, ROS, and HA expression [11,12,14]. Future studies in animal models could illuminate potential interventions to accelerate OVD metabolism in vivo.…”

Section: Discussionmentioning

confidence: 99%

Corneal Opacification and Spontaneous Recovery following Injection of Healon5 into the Corneal Stroma during Intervention for Postoperative Hypotony

Massengill

Blake

2020

Case Rep Ophthalmol

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We report the self-limited nature of corneal opacification after accidental injection of Healon5 into the corneal stroma. A 52-year-old male with a new diagnosis of severe stage, primary open-angle glaucoma underwent successful trabeculectomy OS, which was complicated by ocular hypotony and shallow anterior chamber (AC) on postoperative day 1. Healon5, a hyaluronic acid-containing viscoelastic device, was accidentally introduced into the corneal stroma during attempted injection into the AC. The cornea hydrodissected and opacified, leading to precipitous loss of best-corrected visual acuity (BCVA). The corneal opacification spontaneously resolved over a 7-month period without specific intervention. During this period, the patient also underwent cataract extraction with posterior chamber intraocular lens placement and YAG capsulotomy, after which his BCVA returned to approximately baseline. Though intrastromal injection of sodium hyaluronate-containing material has been reported elsewhere, this complication with Healon5 use specifically has yet to be described in the literature and may occur in any procedure involving Healon5 in the AC. This case report is important, since

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“…Due to a lack of endogenous host enzymes in the small intestine capable of further breaking down free GAGs [142], these molecules remain largely undigested through the majority of the gastrointestinal tract [143], with eventual breakdown likely occurring in the cecum or colon [142]. In the case of HA, and potentially other GAGs, the resulting fragment sizes, whether created by endogenous breakdown of the parent molecule or intentional supplementation of a specific molecular weight, may differ vastly in function [144,145]. A disparity in bioavailability also appears to exist between human and bovine milk.…”

Section: Glycosaminoglycans In Milkmentioning

confidence: 99%

The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review

et al. 2020

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Necrotizing enterocolitis, a potentially fatal intestinal inflammatory disorder affecting primarily premature infants, is a significant cause of morbidity and mortality in neonates. While the etiology of the disease is, as yet, unknown, a number of risk factors for the development of necrotizing enterocolitis have been identified. One such risk factor, formula feeding, has been shown to contribute to both increased incidence and severity of the disease. The protective influences afforded by breastfeeding are likely attributable to the unique composition of human milk, an extremely potent, biologically active fluid. This review brings together knowledge on the pathogenesis of necrotizing enterocolitis and current thinking on the instrumental role of one of the more prominent classes of bioactive components in human breast milk, glycosaminoglycans.

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Hyaluronic Acid in the Third Millennium

Cited by 583 publications

References 239 publications

Melatonin and Hyaluronic Acid in Periodontal Disease

Melatonin and Hyaluronic Acid in Periodontal Disease

Corneal Opacification and Spontaneous Recovery following Injection of Healon5 into the Corneal Stroma during Intervention for Postoperative Hypotony

The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review

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