Hyaluronic acid in the treatment of osteoarthritis of the knee

Huskisson, E.C.; Donnelly, S

doi:10.1093/rheumatology/38.7.602

Cited by 196 publications

(135 citation statements)

References 0 publications

Supporting

Mentioning

123

Contrasting

Unclassified

Order By: Relevance

“…It is a linear natural polysaccharide composed of the repeating disaccharide b-1-4-D-glucuronic acid and b-1-3-N-acetyl-D-glucosamine units. Since HA is a primary ECM component, it has been investigated as scaffolding material for soft tissue engineering applications [1][2][3][4]. HA is biocompatible and a key component in bone and cartilage tissue engineering applications, and thus, a wide range of additional biomedical applications have also been explored [5,6].…”

Section: Introductionmentioning

confidence: 99%

Phosphate salts facilitate the electrospinning of hyaluronic acid fiber mats

et al. 2013

View full text Add to dashboard Cite

Electrospinning is a cost effective and facile method to manufacture fiber mats appropriate for biomedical applications. Due to its high molecular weight and charged backbone, hyaluronic acid (HA) fiber mats with consistent fiber morphology have been difficult to electrospin from neutral pH solutions. Here, we present that the electrospinning of HA fibers in aqueous dimethylformamide solutions is facilitated by the addition of three phosphate salts. The salts-glycerol phosphate (GP), sodium phosphate (SP), and tripolyphosphate (TPP)-facilitated electrospinning of the solutions as characterized by conductivity measurements and fiber morphology. From tensile experiments, HA mats electrospun with SP demonstrated improved Young's modulus (12 MPa) over HA mats spun with either GP or TPP (5 and 3 MPa, respectively). This work demonstrates that a new neutral solvent system can be employed to spin HA fibers, which offers the potential for using the fibers for biomedical applications, such as a bone biomimetic.

show abstract

Section: Introductionmentioning

confidence: 99%

Phosphate salts facilitate the electrospinning of hyaluronic acid fiber mats

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The 14 studies left were reviewed in chronological order (Fig 1). 4,12,[17][18][19][20][21][22][23][24][25][26][27][28] study 1…”

Section: Resultsmentioning

confidence: 99%

“…24,26,27 Finally, two studies showed a modest effect in favour of HA over placebo for pain that was noticeable at six months but not for function. 23,28 Of the two studies that compared HA with steroid injections, one showed no statistically significant difference between the two groups. 12 The other suggested that HA was better at six months than steroid injections but this study had a very high drop out rate at six months, 19 making the results questionable.…”

Section: Discussionmentioning

confidence: 95%

“…23 This was maintained at six months. For knee function, there was a significant improvement at five weeks and at two months in favour of HA but this was not maintained at six months.…”

Section: Studymentioning

confidence: 96%

“…23 The patients were selected according to clearly defined eligibility criteria. A total of 100 patients were randomised into the two study arms, 50 in each group.…”

Section: Studymentioning

confidence: 99%

See 2 more Smart Citations

The effectiveness of hyaluronic acid intra-articular injections in managing osteoarthritic knee pain

Trigkilidas

Anand

2013

annals

View full text Add to dashboard Cite

INTRODUCTION Knee osteoarthritis (OA) is a common and progressive joint disease. Treatment options for knee OA vary from simple analgesia in mild cases to knee replacement for advanced disease. Knee pain due to moderate OA can be targeted with intra-articular injections. Steroid injections have been used widely in managing acute flare-ups of the disease. In recent years, viscosupplementation has been used as a therapeutic modality for the management of knee OA. The principle of viscosupplementation is based on the physiological properties of the hyaluronic acid (HA) in the synovial joint. Despite a sound principle and promising in vitro studies, clinical studies have been less conclusive on the effectiveness of HA in managing osteoarthritic knee pain. The aim of this systematic review was to assess the effectiveness of HA intra-articular injections in the management of osteoarthritic knee pain. METHODS A systematic review of the literature was performed using MEDLINE ® , Embase™ and CINAHL ® (Cumulative Index to Nursing and Allied Health Literature). The databases were searched for randomised controlled trials available on the effectiveness of HA intra-articular injections in managing osteoarthritic knee pain. RESULTS The search yielded 188 studies. Of these, 14 met the eligibility criteria and were reviewed in chronological order. CONCLUSIONS HA intra-articular injections have a modest effect on early to moderate knee OA. The effect peaks at around 6-8 weeks following administration, with a doubtful effect at 6 months.

show abstract

Hyaluronate Sodium Injections for Osteoarthritis: The Truth

Altman¹

2002

Archives of Internal Medicine

View full text Add to dashboard Cite

Hyaluronic acid in the treatment of osteoarthritis of the knee

Abstract: The study demonstrated that five weekly intra-articular injections of sodium hyaluronate (Hyalgan) were superior to placebo and well tolerated in patients with osteoarthritis of the knee with a symptomatic benefit which persisted for 6 months.

Cited by 196 publications

References 0 publications

Phosphate salts facilitate the electrospinning of hyaluronic acid fiber mats

Phosphate salts facilitate the electrospinning of hyaluronic acid fiber mats

The effectiveness of hyaluronic acid intra-articular injections in managing osteoarthritic knee pain

Hyaluronate Sodium Injections for Osteoarthritis: The Truth

Contact Info

Product

Resources

About