Hyaluronic Acid Increases Motility/Intracellular Ca 2+ Concentration in Human Sperm in Vitro

Bains, R.; Miles, D. M.; Rj, Carson; Adeghe, J. H.

doi:10.1080/014850101316901325

Cited by 19 publications

(17 citation statements)

References 16 publications

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“…In the present study, hyaluronic acid did not affect acrosome reaction, but it modulated sperm motility. This is in line with the presence of receptors for hyaluronic acid in human spermatozoa (20,51,52). Although hyaluronic acid does not affect spontaneous acrosome reaction, an earlier report (27) and our unpublished observation have shown that hyaluronic acid enhances progesterone-stimulated acrosome reaction.…”

Section: Discussionsupporting

confidence: 83%

“…The present study is the first to investigate the effect of hyaluronic acid at a concentration (1.0 mg/mL) similar to that in the cumulus oophorus on sperm function; much lower concentrations had been used in earlier reports (20,27). In the present study, hyaluronic acid did not affect acrosome reaction, but it modulated sperm motility.…”

Section: Discussionmentioning

confidence: 63%

“…The action of cumulus cells on sperm function may be mediated via the secretory products of the cells (11,13,18,20,21). Thus, spent medium from cumulus cell culture induced acrosome reaction (11) and stimulated sperm motility (13).…”

mentioning

confidence: 97%

“…Hyaluronic acid is a major component of the cumulus matrix (22)(23)(24)(25) and is synthesized by the cumulus cells after LH surge (26). Hyaluronic acid affects human sperm motility (20) and acrosome reaction (27) in vitro. These latter studies used different hyaluronic acid concentrations up to 100 mg/mL, which is much lower than the concentration (0.5-1 mg/mL) in the cumulus matrix (22,26).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Cumulus cells and their extracellular matrix affect the quality of the spermatozoa penetrating the cumulus mass

Hong

Chiu

Lee

et al. 2009

Fertility and Sterility

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 63%

mentioning

confidence: 97%

mentioning

confidence: 99%

See 2 more Smart Citations

Cumulus cells and their extracellular matrix affect the quality of the spermatozoa penetrating the cumulus mass

Hong

Chiu

Lee

et al. 2009

Fertility and Sterility

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show abstract

“…L-type and T-type VDCCs both can modulate calcium influx and acrosome reaction of human sperm by progesterone mediated [12] . L-type VDCC can involve and response to hyaluronic acid mediated too [13] . T-type VDCC can also response to mannose mediated [14] .…”

Section: Discussionmentioning

confidence: 99%

Pharmacological investigation of voltage-dependent Ca2+ channels in human ejaculatory sperm in vitro

Lü

Liu

et al. 2006

J. Huazhong Univ. Sc. Technol.

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The types of the voltage-dependent calcium channels (VDCCs) in human ejaculatory sperm and the effects of calcium channel blocker (CCB) on human sperm motility parameters in vitro were investigated. The human sperm motility parameters in vitro in response to the pharmacological agents nifedipine (NIF, inhibitor of L-type VDCC) and co-conotoxin (GVIA, inhibitor of N-type VDCC) were compared and analyzed statistically. The results showed that NIF (1, 5, 10 micromol/L) could not only significantly affect human sperm's shape but also spermatozoa motility after incubated at least 10 min in vitro (P<0.001). GVIA (0.1, 0.5 and 1 micromol/L) could just only significantly affect human sperm's progressive motility (a %+b %) after incubated for 20 min in vitro (P<0.01), but they both could not significantly affect spermic abnormality rate. It is suggested that L-type VDCC, non L-type VDCCs and isoform of L-type VDCC exist in the cell membrane of human sperm solely or together, and they participate in the spermic physiological processes especially the spermic motility.

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Exploring the Role of Hyaluronic Acid in Reproductive Biology and Beyond: Applications in Assisted Reproduction and Tissue Engineering

Rashki Ghaleno,

Pennisi,

Shahverdi

et al. 2024

Advanced Biology

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Hyaluronic acid (HA) plays a prominent role in various aspects of reproductive biology and assisted reproductive technologies (ART). This review describes the multifaceted influence of HA, ranging from primordial germ cell migration, ovarian follicle development, and ovulation in females to sperm structure, physiology, motility, and capacitation in males. In addition, HA also plays an important role in fertilization and promotes embryo implantation by mediating cellular adhesion and communication within the uterus. Against this physiological background, the review examines the current applications of HA in the context of ART. In addition, the article addresses the emerging field of reproductive tissue engineering, where HA‐based hydrogels offer promising perspectives as they can support the development of mature oocytes and spermatogenesis in vitro. Overall, this review highlights the integral role of HA in the intricate mechanisms of reproductive biology and its growing importance for improving ART outcomes and the field of tissue engineering of the reproductive system.

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Hyaluronic Acid Increases Motility/Intracellular Ca 2+ Concentration in Human Sperm in Vitro

Cited by 19 publications

References 16 publications

Cumulus cells and their extracellular matrix affect the quality of the spermatozoa penetrating the cumulus mass

Cumulus cells and their extracellular matrix affect the quality of the spermatozoa penetrating the cumulus mass

Pharmacological investigation of voltage-dependent Ca2+ channels in human ejaculatory sperm in vitro

Exploring the Role of Hyaluronic Acid in Reproductive Biology and Beyond: Applications in Assisted Reproduction and Tissue Engineering

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