Hyaluronic acid/lactoferrin–coated polydatin/PLGA nanoparticles for active targeting of CD44 receptors in lung cancer

Nashaat Alnagar, Ahmed; Motawea, Amira; Elamin, Khaled M.; Abu Hashim, Irhan Ibrahim

doi:10.1080/10837450.2024.2414937

Pharmaceutical Development and Technology

2024

DOI: 10.1080/10837450.2024.2414937

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Hyaluronic acid/lactoferrin–coated polydatin/PLGA nanoparticles for active targeting of CD44 receptors in lung cancer

Ahmed Nashaat Alnagar,

Amira Motawea,

Khaled M. Elamin

et al.

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Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture

Akdaşçi,

Eker,

Duman

et al. 2024

Nanomaterials

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Nanoparticles (NPs) have emerged as a potent choice for various applications, from drug delivery to agricultural studies, serving as an alternative and promising methodology for future advancements. They have been widely explored in delivery systems, demonstrating immense promise and high efficiency for the delivery of numerous biomolecules such as proteins and anticancer agents, either solely or modified with other compounds to enhance their capabilities. In addition, the utilization of NPs extends to antimicrobial studies, where they are used to develop novel antibacterial, antifungal, and antiviral formulations with advanced characteristics. Lactoferrin (Lf) is a glycoprotein recognized for its significant multifunctional properties, such as antimicrobial, antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Its activity has a broad distribution in the human body, with Lf receptors present in multiple regions. Current research shows that Lf is utilized in NP technology as a surface material, encapsulated biomolecule, and even as an NP itself. Due to the abundance of Lf receptors in various regions, Lf can be employed as a surface material in NPs for targeted delivery strategies, particularly in crossing the BBB and targeting specific cancers. Furthermore, Lf can be synthesized in an NP structure, positioning it as a strong candidate in future NP-related applications. In this article, we explore the highlighted and underexplored areas of Lf applications in NPs research.

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Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture

Akdaşçi,

Eker,

Duman

et al. 2024

Nanomaterials

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Hyaluronic acid/lactoferrin–coated polydatin/PLGA nanoparticles for active targeting of CD44 receptors in lung cancer

Cited by 1 publication

References 107 publications

Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture

Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture

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