Hyaluronic acid/lactose-modified chitosan electrospun wound dressings – Crosslinking and stability criticalities

Gruppuso, Martina; Iorio, Francesco; Turco, Gianluca; Marsich, Eleonora; Porrelli, Davide

doi:10.1016/j.carbpol.2022.119375

Cited by 30 publications

(12 citation statements)

References 122 publications

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“…Figure 7C displays the photos of water absorption experiment of a freeze-dried hydrogel at different time point. The results of water absorption test indicated that the Pul-NB hydrogels were capable of 112 absorbing water up to 120 times of their dry weight, which had the similar advantages with synthetic superabsorbent polymers and bio-based hyaluronic acid [ 48 - 50 ] .…”

Section: Resultsmentioning

confidence: 99%

A novel photocurable pullulan-based bioink for digital light processing 3D printing

Feng¹,

Li²,

Zhou³

et al. 2022

IJB

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Digital light processing has significant advantages, such as high repeatability, low failure rate, and no extrusion shear force. To make it possible to print complex structures with high resolution, the consecutive development of photocurable ink materials is indispensable. In this work, photo-functionalized pullulan (Pul-NB) was prepared by introducing norbornene groups into pullulan chains, and an ink material suitable for photocurable printing was prepared by thiol-ene click reaction. The rheology, water absorption, and mechanical properties of the Pul-NB precursor solution and photocurable hydrogel were investigated. The optimal composition of Pul-NB ink for three-dimensional (3D) printing was obtained by adjusting the degree of substitution, Pul-NB concentration, and thiol crosslinking agent. This novel bioink for digital light processing 3D printing showed good printability and high shape fidelity. This ink material provides an excellent alternative for printing biomimetic soft tissue organs, high-throughput tissue models, soft robots, etc.

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Section: Resultsmentioning

confidence: 99%

A novel photocurable pullulan-based bioink for digital light processing 3D printing

Feng¹,

Li²,

Zhou³

et al. 2022

IJB

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“…Compared with traditional non-steroidal anti-inflammatory and steroid drugs, intra-articular injection of HA is an excellent choice for the treatment of knee OA. 28 CD44, a single transmembrane protein, is the main receptor of HA in chondrocytes. The cartilage extracellular matrix can be affected by HA binding.…”

Section: Discussionmentioning

confidence: 99%

Hyaluronic acid–gold nano-optical probes and determination of their effect on the inhibition of osteoarthritis progression

et al. 2023

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Osteoarthritis seriously affects the health of elderly individuals. In this study, hyaluronic acid–gold nano-optical probes (HA–GNPs) were prepared, and their effect on osteoarthritis and its underlying mechanism were explored. The HA–GNPs were synthesised via a one-step synthesis method and characterised and detected via ultraviolet–visible spectrophotometry, dynamic light scattering (particle size analysis), zeta potential analysis, and scanning and transmission electron microscopy. The cytotoxicity of the probes was determined using CCK-8 detection, fluorescent staining of dead and living cells, and an in vivo animal model, and related staining methods were established to identify the potential therapeutic capabilities of the probes. Our study showed that the synthesised HA–GNPs were more stable and suitable for probe construction than traditional sodium citrate–gold nanoparticles. The HA–GNPs were also found to be biocompatible and suitable for in vitro and in vivo experiments and clinical applications. These findings showed that HA–GNPs exert a substantial inhibitory effect on osteoarticular chondrocytes and offer a promising method for improving healing from osteoarthritis in the clinical setting in the future.

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“…Although glutaraldehyde has been reported as the most commonly used crosslinker agent ( Guo et al, 2016 ; Zhang et al, 2017 ), its hazardous nature could impair scaffold transplantation in tissue engineering scenarios. In this regard, research efforts have been focused on the use of less cytotoxic and more environmental friendly crosslinking strategies, encompassing benign crosslinkers (e.g., genipin, enzymes, EDC alone or with NHS) ( Gruppuso et al, 2022 ), polysaccharide complexation ( Chen et al, 2021 ), thermal treatment (C Madruga et al, 2021 ) or UV-light exposure ( Kianfar et al, 2019 ). While these green methods require the use of catalysts or external energy inputs for post-crosslinking electrospun fibers, a fast and one-step fiber drawing and crosslinking approach was recently proposed in the form of multiple fibrous hydrogel populations ( Figure 3A ).…”

Section: Biomaterials Processing Routes and Their Biomedical Applicat...mentioning

confidence: 99%

Green approaches for extraction, chemical modification and processing of marine polysaccharides for biomedical applications

Sacramento

Borges

Correia

et al. 2022

Front. Bioeng. Biotechnol.

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Over the past few decades, natural-origin polysaccharides have received increasing attention across different fields of application, including biomedicine and biotechnology, because of their specific physicochemical and biological properties that have afforded the fabrication of a plethora of multifunctional devices for healthcare applications. More recently, marine raw materials from fisheries and aquaculture have emerged as a highly sustainable approach to convert marine biomass into added-value polysaccharides for human benefit. Nowadays, significant efforts have been made to combine such circular bio-based approach with cost-effective and environmentally-friendly technologies that enable the isolation of marine-origin polysaccharides up to the final construction of a biomedical device, thus developing an entirely sustainable pipeline. In this regard, the present review intends to provide an up-to-date outlook on the current green extraction methodologies of marine-origin polysaccharides and their molecular engineering toolbox for designing a multitude of biomaterial platforms for healthcare. Furthermore, we discuss how to foster circular bio-based approaches to pursue the further development of added-value biomedical devices, while preserving the marine ecosystem.

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Hyaluronic acid/lactose-modified chitosan electrospun wound dressings – Crosslinking and stability criticalities

Cited by 30 publications

References 122 publications

A novel photocurable pullulan-based bioink for digital light processing 3D printing

A novel photocurable pullulan-based bioink for digital light processing 3D printing

Hyaluronic acid–gold nano-optical probes and determination of their effect on the inhibition of osteoarthritis progression

Green approaches for extraction, chemical modification and processing of marine polysaccharides for biomedical applications

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