Hyaluronic acid-modified, IR780-conjugated and doxorubicin-loaded reduced graphene oxide for targeted cancer chemo/photothermal/photodynamic therapy

Dash, Banendu Sunder; Lu, Yu-Jen; Pejrprim, Pidsarintun; Lan, Yu-Hsiang; Chen, Jyh‐Ping

doi:10.1016/j.bioadv.2022.212764

Cited by 40 publications

(14 citation statements)

References 59 publications

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“…In addition, the FerH solution exhibited a high photostability with negligible attenuation of peak solution temperatures after five “On-Off” cycles of laser irradiation ( Figure 2 G ). The photothermal conversion efficiency of FerH nanoaggregates was calculated as 60.2% ( Figure S16 ), which was the record-high the previously-reported MPN photothermal nanosystems including Fe-(-)-epigallocatechin-3-gallate-gossypol (FeEG) 28 , Fe-tannic acid (FeTA) 29 , Vanadium-TA (VTA) 29 , and Ruthenium-TA (RuTA) 29 , Fe-anthocyanins (FeAP) 30 , Fe-gallic acid (FeGA) 31 , and other PTAs like, Fe 3 O 4 41 , Au nanorods (AuNR) 42 , black phosphorus (BP) 43 , Au-ZIF8 44 , graphene oxide (GO) 45 , although not as high as graphene 45 ( Figure 2 H ).…”

Section: Photothermal Conversion Of Ferhsupporting

confidence: 59%

Intratumoral synthesis of transformable metal-phenolic nanoaggregates with enhanced tumor penetration and retention for photothermal immunotherapy

He¹,

Zhu²,

Shang³

et al. 2022

Theranostics

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Rationale: Effective photothermal therapy (PTT) remains a great challenge due to the difficulties of delivering photothermal agents with both deep penetration and prolonged retention at tumor lesion spatiotemporally. Methods : Here, we report an intratumoral self-assembled nanostructured aggregate named FerH, composed of a natural polyphenol and a commercial iron supplement. FerH assemblies possess size-increasing dynamic kinetics as a pseudo-stepwise polymerization from discrete nanocomplexes to microscale aggregates. Results : The nanocomplex can penetrate deeply into solid tumors, followed by prolonged retention (> 6 days) due to the in vivo growth into nanoaggregates in the tumor microenvironment. FerH performs a targeting ablation of tumors with a high photothermal conversion efficiency (60.2%). Importantly, an enhanced immunotherapeutic effect on the distant tumor can be triggered when co-administrated with checkpoint-blockade PD-L1 antibody. Conclusions : Such a therapeutic approach by intratumoral synthesis of metal-phenolic nanoaggregates can be instructive to address the challenges associated with malignant tumors.

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Section: Photothermal Conversion Of Ferhsupporting

confidence: 59%

Intratumoral synthesis of transformable metal-phenolic nanoaggregates with enhanced tumor penetration and retention for photothermal immunotherapy

He¹,

Zhu²,

Shang³

et al. 2022

Theranostics

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“…The tissues were sectioned into 5 μm thickness on a glass slide after paraffin embedment. Slides were then subject to hematoxylin and eosin (H&E) and immunohistochemical (IHC) staining following standard protocols [ 40 ]. For IHC staining, rabbit anti-mouse phospho-ERK (4376S, Cell Signaling, 1:200) or cleaved caspase-3 primary antibody (9661S, Cell Signaling, 1:100) was used.…”

Section: Methodsmentioning

confidence: 99%

“…Many nanoparticle-based drug delivery systems for cancer therapy use surface-bound HA as a ligand molecule to actively target cancer cells and to improve the intracellular uptake efficiency [ 38 ]. This is linked to overexpressed CD44 receptors on the surface of these cell lines [ 39 ], including the U87 glioblastoma cells [ 40 ]. Furthermore, owing to the hydrophilic and electronegative properties, the protein adsorption on nanoparticles will be impeded after HA modification [ 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid-Modified Cisplatin-Encapsulated Poly(Lactic-co-Glycolic Acid) Magnetic Nanoparticles for Dual-Targeted NIR-Responsive Chemo-Photothermal Combination Cancer Therapy

Chen

Dash

et al. 2023

Pharmaceutics

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Combination chemo-photothermal therapy with nanomaterials can reduce the dose of chemotherapeutic drugs required for effective cancer treatment by minimizing toxic side effects while improving survival times. Toward this end, we prepare hyaluronic acid (HA)-modified poly(lactic-co-glycolic acid) (PLGA) magnetic nanoparticles (MNP) for the CD44 receptor-mediated and magnetic field-guided dual-targeted delivery of cisplatin (CDDP). By co-encapsulating the CDDP and oleic acid-coated iron oxide MNP (IOMNP) in PLGA, the PMNPc was first prepared in a single emulsification/solvent evaporation step and successively surface modified with chitosan and HA to prepare the HA/PMNPc. Spherical HA/PMNPc nanoparticles of ~300 nm diameter can be prepared with 18 and 10% (w/w) loading content of CDDP and IOMNP and a pH-sensitive drug release to facilitate the endosomal release of the CDDP after intracellular uptake. This leads to the higher cytotoxicity of the HA/PMNPc toward the U87 glioblastoma cells than free CDDP with reduced IC50, a higher cell apoptosis rate, and the enhanced expression of cell apoptosis marker proteins. Furthermore, the nanoparticles show the hyperthermia effect toward U87 after short-term near-infrared (NIR) light exposure, which can further elevate the cell apoptosis/necrosis rate and upregulate the HSP70 protein expression due to the photothermal effects. The combined cancer therapeutic efficacy was studied in vivo using subcutaneously implanted U87 cells in nude mice. By using dual-targeted chemo-photothermal combination cancer therapy, the intravenously injected HA/PMNPc under magnetic field guidance and followed by NIR laser irradiation was demonstrated to be the most effective treatment modality by inhibiting the tumor growth and prolonging the survival time of the tumor-bearing nude mice.

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“…Loading doxorubicin inside the fabricated carrier grants it a pH-responsive feature, leading to the release of higher amounts of the drug in low pH of endosomes in comparison to the normal pH, which could reduce the side effects of nanoformulation on normal cells. 124 Graphene quantum dots (GQDs), the tiny-sized graphenebased nanomaterials with interesting electrochemical and optical properties, were applied for the fabrication of biosensors for sensitive and selective analyte detection. For example, a nanocomposite of angiopep-2 (Ang-2)-sulfur-doped Ang-2-GQDs functionalized on the surface of gold nanoparticle-decorated carbon nanospheres (Au-CNS) was applied for the fabrication of an ultrasensitive pulse-induced electrochemical biosensor for the detection of glioma cells (Fig.…”

Section: Brain Tumors and Neurological Cancersmentioning

confidence: 99%

Graphene- and MXene-based materials for neuroscience: diagnostic and therapeutic applications

Zarepour,

Karasu,

Mir

et al. 2023

Biomater. Sci.

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Hyaluronic acid-modified, IR780-conjugated and doxorubicin-loaded reduced graphene oxide for targeted cancer chemo/photothermal/photodynamic therapy

Cited by 40 publications

References 59 publications

Intratumoral synthesis of transformable metal-phenolic nanoaggregates with enhanced tumor penetration and retention for photothermal immunotherapy

Intratumoral synthesis of transformable metal-phenolic nanoaggregates with enhanced tumor penetration and retention for photothermal immunotherapy

Hyaluronic Acid-Modified Cisplatin-Encapsulated Poly(Lactic-co-Glycolic Acid) Magnetic Nanoparticles for Dual-Targeted NIR-Responsive Chemo-Photothermal Combination Cancer Therapy

Graphene- and MXene-based materials for neuroscience: diagnostic and therapeutic applications

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