Hyaluronic‐Acid‐Presenting Self‐Assembled Nanoparticles Transform a Hyaluronidase HYAL1 Substrate into an Efficient and Selective Inhibitor

Duan, Haohao; Donovan, Mark; Hernandez, Franck; Primo, Carmelo Di; Garanger, Élisabeth; Schultze, Xavier; Lecommandoux, Sébastien

doi:10.1002/ange.202005212

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…[23] More interestingly, HA-based nanostructures may not only be stable against HAase but also inhibit this enzyme from degrading free HA, as reported by Duan et al with micelles from HA grafted with poly(γ-benzyl-l-glutamate) as a potential HAase inhibitor for biomedical applications. [181] Therefore, HAase-induced degradation should not be generalized for all HA-based colloidal PECs and needs to be evaluated case by case, which can verify their potential as a HAase-responsive system for tumor targeting or a HAase-inhibiting agent. Furthermore, when HA-based colloidal PECs are degradable by HAase, one may doubt whether such a degradation can be catalyzed by extracellular HAase in tumors and liberate free HA fragments that compete with PECs for interactions with CD44 receptors.…”

Section: Current Limitations and Future Perspectivesmentioning

confidence: 99%

Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

Cerf

2022

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nanocomplexes, [8,9] nanocomposites, [10,11] nanoassemblies [12] and coacervates. [13,14] Such colloidal systems, especially when prepared from biopolymers, have been extensively investigated due to their promising properties for numerous applications in biomedical fields. [1] Their merits come from the combination of three aspects: nanomedicine, biomaterials, and green chemistry. With the emergence of nanomedicine, the use of nanocarriers can offer tremendous advantages in drug encapsulation and delivery, namely enhancing the chemical stability of drugs and improving drug solubility and bioavailability. [15] Due to their small size and the possibility of surface modification with biological ligands or molecular imprinting, nanocarriers can easily cross biological barriers, which have limited pore sizes (fenestrations) under 1 micron in most cases, then target and enter the tissues or cells of interest. [16,17] Due to these aspects and the possibility of controlling drug distribution and release through particle engineering, nanocarriers can thus reduce systemic side effects and enhance the therapeutic efficacy of drugs. [15] Nanosystems can also offer unique advantages for biomedical imaging with their ability of sensing, image enhancement, and incorporating concomitantly therapeutic agents for theranostics, that is, simultaneous therapeutic and diagnostic applications. [18][19][20] When constructed from biomaterials, especially naturally occurring polysaccharides or proteins, PECs can become significantly biocompatible and biodegradable with much less immunogenicity and toxicity. [21] Besides such biorelevant aspects, the elaboration of biopolymerbased PECs is also in accordance with green chemistry principles since their preparation process usually requires only gentle mixing of polyelectrolyte solutions at room temperature, which is a simple and rapid procedure without the need for chemical agents, surfactants, organic solvents or high mechanical or thermal energy. [15] Beyond the above-mentioned basic advantages, the potential of colloidal PEC systems is increased by the inherent biological and chemical properties of individual constituent polymers. Hyaluronic acid (HA), also called hyaluronan to generally mention both its acid and salt forms, has been one of the most common polyanions among several biopolymers reported so far for the elaboration of colloidal PECs. The significant attention dedicated to HA in biomedical fields is associated with its unique advantages, stemming from not only its outstanding biocompatibility but also interesting biological activities. [22] Hyaluronic acid (HA) is a naturally occurring polysaccharide which has been extensively exploited in biomedical fields owing to its outstanding biocompatibility. Self-assembly of HA and polycations through electrostatic interactions can generate colloidal polyelectrolyte complexes (PECs), which can offer a wide range of applications while being relatively simple to prepare with rapid and "green" processes. The advantages of colloidal HA-base...

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Section: Current Limitations and Future Perspectivesmentioning

confidence: 99%

Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

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2022

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“…94 (Fig. 15A) A 17 kDa ELP[M1V3-40] was functionalized at the Nterminal chain end with an alkyne-containing linker and conjugated to three different azido-terminated oligosaccharides with specific receptor binding ability, namely laminarihexaose, 95 low molar mass HA, 96,97 and dextran yielding three distinct bioconjugates that were characterized by NMR spectroscopy and size-exclusion chromatography (SEC) noted Lam-b-ELP, HA-b-ELP and Dexb-ELP, respectively. (Fig.…”

Section: Elp-polysaccharides Bioconjugatesmentioning

confidence: 99%

Emerging opportunities in bioconjugates of Elastin-like polypeptides with synthetic or natural polymers

Garanger

Lecommandoux

2022

Advanced Drug Delivery Reviews

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Dual Gate‐Controlled Therapeutics for Overcoming Bacterium‐Induced Drug Resistance and Potentiating Cancer Immunotherapy

et al. 2021

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The presence of bacteria in the tumor can cause cancer resistance to chemotherapeutics.T of ight against bacterium-induced drug resistance,h erein we design selftraceable nanoreservoirs that are simultaneously loaded with gemcitabine (an anticancer drug) and ciprofloxacin (an antibiotic) and are decorated with hyaluronic acid for active tumor targeting.The nanoreservoirs have apH-sensitive gate and an enzyme-responsive gate that can be opened in the acidic and hyaluronidase-abundant tumor microenvironment to control drug release rates.M oreover,t he nanoreservoirs can specifically target the tumor regions without eliciting evident toxicity to normal tissues,kill the intratumoral bacteria, and inhibit the tumor growth even in the presence of the bacteria. Unexpectedly,t he nanoreservoirs can activate Tc ell-mediated immune responses through promoting antigen-presenting dendritic cell maturation and depleting immunosuppressive myeloid-derived suppressor cells in bacterium-infected tumors.

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Hyaluronic‐Acid‐Presenting Self‐Assembled Nanoparticles Transform a Hyaluronidase HYAL1 Substrate into an Efficient and Selective Inhibitor

Cited by 6 publications

References 36 publications

Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

Emerging opportunities in bioconjugates of Elastin-like polypeptides with synthetic or natural polymers

Dual Gate‐Controlled Therapeutics for Overcoming Bacterium‐Induced Drug Resistance and Potentiating Cancer Immunotherapy

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