Hyaluronic acid/tannic acid films for wound healing application

Wekwejt, Marcin; Małek, Marcin; Ronowska, Anna; Michno, Anna; Pałubicka, Anna; Zasada, Lidia; Klimek, Agnieszka; Kaczmarek-Szczepańska, Beata

doi:10.1016/j.ijbiomac.2023.128101

Cited by 11 publications

(7 citation statements)

References 61 publications

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“…Our AFM results (Table 1) indicated that the surface roughness of hyaluronic acid/ellagic acid films, regardless of the ellagic acid solvent used, fell within the microroughness range. This differed from hyaluronic acid/tannic acid films studied previously [29], which exhibited lower roughness parameters (Ra and Rq below 5 nm). The very strong hydrophilicity of the hyaluronic acid/ellagic acid films was evidenced by the immediate melting of glycerin or iodomethane drops upon application to the film surface.…”

Section: Discussioncontrasting

confidence: 90%

“…The very strong hydrophilicity of the hyaluronic acid/ellagic acid films was evidenced by the immediate melting of glycerin or iodomethane drops upon application to the film surface. This hydrophilicity is consistent with the values reported for hyaluronic acid films [ 31 ] and offers advantages for potential cell interactions and biocompatibility [ 29 , 32 ]. Additionally, each of the materials based on HA/EA is hydrophilic since all the values of the contact angles are less than 90°.…”

Section: Discussionsupporting

confidence: 89%

“…It influences cellular morphology, proliferation, and phenotype expression. Surface roughness is classified into macroroughness (100 μm to 1 mm), microroughness (100 nm to 100 μm), and nanoroughness (<100 nm) [ 29 , 30 ]. Our AFM results ( Table 1 ) indicated that the surface roughness of hyaluronic acid/ellagic acid films, regardless of the ellagic acid solvent used, fell within the microroughness range.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, each of the materials based on HA/EA is hydrophilic since all the values of the contact angles are less than 90°. The enhanced hydrophilicity of the materials can provide additional advantages for potential cell interactions with the surface and the materials’ biocompatibility [ 29 , 32 ]. HA/EA films dissolved in NaOH in the same weight ratio (50HA/50EA/NaOH) were characterized by the highest hydrophilicity.…”

Section: Discussionmentioning

confidence: 99%

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Hyaluronic Acid/Ellagic Acid as Materials for Potential Medical Application

Kaczmarek-Szczepańska,

Kleszczyński,

Zasada

et al. 2024

IJMS

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The aim of this work was to develop and characterize a thin films composed of hyaluronic acid/ellagic acid for potential medical application. Its principal novelty, distinct from the prior literature in terms of hyaluronic acid films supplemented with phenolic acids, resides in the predominant incorporation of ellagic acid—a distinguished compound—as the primary constituent of the films. Herein, ellagic acid was dissolved in two different solvents, i.e., acetic acid (AcOH) or sodium hydroxide (NaOH), and the surface properties of the resultant films were assessed using atomic force microscopy and contact angle measurements. Additionally, various physicochemical parameters were evaluated including moisture content, antioxidant activity, and release of ellagic acid in phosphate buffered saline. Furthermore, the evaluation of films’ biocompatibility was conducted using human epidermal keratinocytes, dermal fibroblasts, and human amelanotic melanoma cells (A375 and G361), and the antimicrobial activity was elucidated accordingly against Staphylococcus aureus ATCC 6538 and Pseudomonas aeruginosa ATCC 15442. Our results showed that the films exhibited prominent antibacterial properties particularly against Staphylococcus aureus, with the 80HA/20EA/AcOH film indicating the strong biocidal activity against this strain leading to a significant reduction in viable cells. Comparatively, the 50HA/50EA/AcOH film also displayed biocidal activity against Staphylococcus aureus. This experimental approach could be a promising technique for future applications in regenerative dermatology or novel strategies in terms of bioengineering.

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hyaluronic Acid/Ellagic Acid as Materials for Potential Medical Application

Kaczmarek-Szczepańska,

Kleszczyński,

Zasada

et al. 2024

IJMS

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“…This interaction is advantageous due to the distinctive whisker structure on the surface of hHAP, enabling full contact with the cells. The surface roughness of the scaffold can influence cell proliferation and osseointegration, − with osteoblasts showing a preference for rough surfaces …”

Section: Discussionmentioning

confidence: 99%

Chestnut-Inspired Hollow Hydroxyapatite 3D Printing Scaffolds Accelerate Bone Regeneration by Recruiting Calcium Ions and Regulating Inflammation

Wei,

Zhou,

Xiong

et al. 2024

ACS Appl. Mater. Interfaces

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This study aims to overcome the drawbacks associated with hydroxyapatite (HAP) dense structures after sintering, which often result in undesirable features such as large grain size, reduced porosity, high crystallinity, and low specific surface area. These characteristics hinder osseointegration and limit the clinical applicability of the material. To address these issues, a new method involving the preparation of hollow hydroxyapatite (hHAP) microspheres has been proposed. These microspheres exhibit distinctive traits including weak crystallization, high specific surface area, and increased porosity. The weak crystallization aligns more closely with early mineralization products found in the human body and animals. Moreover, the microspheres' high specific surface area and porosity offer advantages for protein loading and facilitating osteoblast attachment. This innovative approach not only mitigates the limitations of conventional HAP structures but also holds the potential for improving the effectiveness of hydroxyapatite in biomedical applications, particularly in enhancing osseointegration. Three-dimensional printed hHAP/chitosan (CS) scaffolds with different hHAP concentration gradients were manufactured, and the physical and biological properties of each group were systematically evaluated. In vitro and in vivo experiments show that the hHAP/CS scaffold has excellent performance in bone remodeling. Furthermore, in-scaffold components, hHAP and CS were cocultured with bone marrow mesenchymal stem cells to explore the regulatory role of hHAP and CS in the process of bone healing and to reveal the cell-level specific regulatory network activated by hHAP. Enrichment analysis showed that hHAP can promote bone regeneration and reconstruction by recruiting calcium ions and regulating inflammatory reactions.

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Tannic Acid Incorporated Antibacterial Polyethylene Glycol Based Hydrogel Sponges for Management of Wound Infections

Akin,

Akgul,

Tasdurmazli

et al. 2024

Macromolecular Bioscience

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Conventional wound dressings fail to provide features that can assist the healing process of chronic wounds. Multifunctional wound dressings address this issue by incorporating attributes including antibacterial and antioxidant activity, and the ability to enhance wound healing. Herein, polyethylene glycol‐based antibacterial hydrogel sponge dressings were prepared by a rapid and facile gas foaming method based on an acid chloride/alcohol reaction where tannic acid (TA) was included as a reactant to impart antibacterial efficacy as well as to enhance the mechanical properties of the samples. The results revealed that the TA‐integrated sponges possess excellent antibacterial properties against both E. coli and S. aureus with approximately 6–8 log reduction in the microbial colony count after 6 hours, indicating their high potential for management of infection‐prone wounds. Compared to the control sample, TA incorporation increased the elastic modulus by two‐fold. As the samples also exhibit biocompatibility, antioxidant activity and wound healing capacity, the novel TA‐incorporated hydrogels can be an alternative to traditional wound dressings for wounds with low‐to‐moderate exudate.This article is protected by copyright. All rights reserved

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Hyaluronic acid/tannic acid films for wound healing application

Cited by 11 publications

References 61 publications

Hyaluronic Acid/Ellagic Acid as Materials for Potential Medical Application

Hyaluronic Acid/Ellagic Acid as Materials for Potential Medical Application

Chestnut-Inspired Hollow Hydroxyapatite 3D Printing Scaffolds Accelerate Bone Regeneration by Recruiting Calcium Ions and Regulating Inflammation

Tannic Acid Incorporated Antibacterial Polyethylene Glycol Based Hydrogel Sponges for Management of Wound Infections

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